NAR1_NEOFI
ID NAR1_NEOFI Reviewed; 597 AA.
AC A1CWD8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor NAR1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=NAR1; ORFNames=NFIA_104280;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; DS027685; EAW24940.1; -; Genomic_DNA.
DR RefSeq; XP_001266837.1; XM_001266836.1.
DR AlphaFoldDB; A1CWD8; -.
DR SMR; A1CWD8; -.
DR STRING; 36630.CADNFIAP00010068; -.
DR EnsemblFungi; EAW24940; EAW24940; NFIA_104280.
DR GeneID; 4593699; -.
DR KEGG; nfi:NFIA_104280; -.
DR VEuPathDB; FungiDB:NFIA_104280; -.
DR eggNOG; KOG2439; Eukaryota.
DR HOGENOM; CLU_018240_0_1_1; -.
DR OMA; PHEQRAW; -.
DR OrthoDB; 705416at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..597
FT /note="Cytosolic Fe-S cluster assembly factor NAR1"
FT /id="PRO_0000383731"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 61
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 64
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 67
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 208
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 263
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 464
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 468
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64248 MW; 3EBDC83A025ACDE7 CRC64;
MSAILSADDL NDFISPGVAC IKPVESLPQK ESQSENPYEV TKEDKVQPEN LPPAQISLTD
CLACSGCVTS AEAVLISLQS HTEVLNTLDL YPELPLDFAS DQRGTQNVGS ADSDSRIFVA
SVSPQVRASL AATYGITERE AKYMIDQFLM GPHGLRAGGK HGNGFTWVVD TNVMREAVLA
LTADEVTNSL LSTGSGSLPK SPILSSACPG WICYAEKTHP FILPHLSRLK SPQALSGTFL
KSVLSKALGV SPSQIWHLAI MPCFDKKLEA SREELTDIAW ASTSAESQTT PVRDVDCVIT
TRELLTLASA RGLSLPNLPL KALPASCSTP FPDQALDSFL FSKSSSDQTV ESGTSGGYLH
HVLKIFQARN PGSKIVTQRG RNADVVEYVL MSSGDEPLLK AARYYGFRNI QNLVRKLKPA
RVSRLPGAKP QAVTSSANRR QPMSRNAAPA GTGADYAYVE VMACPGGCTN GGGQIRIEDA
REAVPNALKE TSTETPVAAS KPTPHEQRAR LARVDEAYYS ADSDSEGSVT TEPVSVLSRD
TKIHEFLKYW SEKIDIPLSQ LAYTSYREVE SDVGKTQNAP NETARVVELA GKIGGGW
