NAR1_NEUCR
ID NAR1_NEUCR Reviewed; 581 AA.
AC Q7SGW5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Cytosolic Fe-S cluster assembly factor nar-1;
DE AltName: Full=Nuclear architecture-related protein 1;
GN Name=nar-1; ORFNames=NCU03204;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC Required for maturation of extramitochondrial Fe/S proteins. May play a
CC role in the transfer of pre-assembled Fe/S clusters to target
CC apoproteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; CM002236; EAA36068.1; -; Genomic_DNA.
DR RefSeq; XP_965304.1; XM_960211.2.
DR AlphaFoldDB; Q7SGW5; -.
DR STRING; 5141.EFNCRP00000002996; -.
DR EnsemblFungi; EAA36068; EAA36068; NCU03204.
DR GeneID; 3881453; -.
DR KEGG; ncr:NCU03204; -.
DR VEuPathDB; FungiDB:NCU03204; -.
DR HOGENOM; CLU_018240_0_1_1; -.
DR InParanoid; Q7SGW5; -.
DR OMA; PHEQRAW; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..581
FT /note="Cytosolic Fe-S cluster assembly factor nar-1"
FT /id="PRO_0000383732"
FT BINDING 20
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 68
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 71
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 74
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 215
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 270
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 457
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 461
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 581 AA; 62288 MW; 500914271BF641BA CRC64;
MSAILSVDDL NDFISPGVAC IKPIETLPTA APPAGDANSS LEVEVILDGQ QPEAKSNAPP
AEISLTDCLA CSGCVTSAEA VLVSLQSHNE VLNMLDSAPA LKLVGPDANG KHSVQGLENS
DAKLYVASVS PQSRASLAAA CGNGVTEQQA GRMIEQLFLG EQGLARGGKW GNKFTWVVDT
NTAREATLVL GSDEVLGGLI APSDKAATPV LTASCPGWVC YAEKTHPYVL PHLSRVKSPQ
ALMGTLLKTS LSRILDIAPE RIWHLAVMPC FDKKLEASRE ELTDAVWAGD GKPGRGVRDV
DCVITSKEVL MLAASRGFDF FSLSASMPPQ TPRFPDQLIH DFLFRPGHRQ QSREAGTSGG
NMHFILRHLQ AKNPGSQIQT VPGRNADVVE YKLIAEAGEV MFKAARYYGF RNIQNLVRKL
KPAKTSRMPG GKPFGSAKRP AGKASGLDYG YVEVMACPGG CTNGGGQIKV DDQVVVDRKG
LAVKPGPQEQ KEWQKEVDEA YFSGDESGSR AQDESLDLVV DGISPSHIRN VLTHWSTLTG
IQLERLAYTS YREVVSDVGK EKKMTDTERV VQLAGKIGGG W
