ID   NAR1_TALMQ              Reviewed;         590 AA.
AC   B6QQH9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Cytosolic Fe-S cluster assembly factor nar1;
DE   AltName: Full=Nuclear architecture-related protein 1;
GN   Name=nar1; ORFNames=PMAA_041970;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery.
CC       Required for maturation of extramitochondrial Fe/S proteins. May play a
CC       role in the transfer of pre-assembled Fe/S clusters to target
CC       apoproteins (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; DS995904; EEA20350.1; -; Genomic_DNA.
DR   RefSeq; XP_002151350.1; XM_002151314.1.
DR   AlphaFoldDB; B6QQH9; -.
DR   SMR; B6QQH9; -.
DR   STRING; 441960.B6QQH9; -.
DR   PRIDE; B6QQH9; -.
DR   EnsemblFungi; EEA20350; EEA20350; PMAA_041970.
DR   GeneID; 7028822; -.
DR   KEGG; tmf:PMAA_041970; -.
DR   VEuPathDB; FungiDB:PMAA_041970; -.
DR   HOGENOM; CLU_018240_0_1_1; -.
DR   OrthoDB; 705416at2759; -.
DR   PhylomeDB; B6QQH9; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..590
FT                   /note="Cytosolic Fe-S cluster assembly factor nar1"
FT                   /id="PRO_0000383734"
FT   BINDING         20
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         62
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         65
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         68
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         214
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         269
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         456
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         460
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   590 AA;  64231 MW;  1EEFA3868B8E6FFA CRC64;
     MSAILSADDL NDFISPGLAC IKPVENFPQK NTASEENAYE VTTEDKIQPE NQAPTQISLT
     DCLACSGCVT SAEAVLISLQ SHAEVLNTLD AHRPAPLIIT QDGNLSVSRK IEPDERIFVA
     SVSPQVRASL AATYDISERK AGHMIDQLLR GPQGLRNGGK HGNGFTWVLD TNVLRQMVLT
     LAAQEVTEAL HTSSASSGSG KYTSPKKPIL SSACPGWICY AEKTHPHVLP HLSRLKSPQA
     LSGTFVKSIL SRTLGIAPSQ IWHLAVMPCF DKKLEASREE LTDAAWSNIS DSPVRDVDCV
     ITSRELLMLA SSRNISLPSL PLKSLAPTYA PHFPDPTVDS FLFSHTQTSK QSSKYGTSGG
     YLYYILLLHK EKHPGSRIEV QRGRNSDVIE YSLMSETNEA IMKAARYYGF RNIQNLVRKM
     KPARASRLPG ANRRGAAGSG ASSSGLDYAF VEVMACPGGC TNGGGQIRLD DAREANASLH
     SATPNDSAVT TQKHTTYEQR QWLSRVDEAY FSAESDSEDE AKPAATGSSL HDMEIRTRDI
     LQYWTNLTGA QLEDLVYTTF RKVESDVGKD KNVNDTTRVA ELAGKIGGGW