ID   NARE_CHICK              Reviewed;         300 AA.
AC   Q92080; Q91050;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Erythroblast NAD(P)(+)--arginine ADP-ribosyltransferase;
DE            EC=2.4.2.31;
DE   AltName: Full=Mono(ADP-ribosyl)transferase;
DE   Flags: Precursor;
GN   Name=MADPRT;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Blood;
RX   PubMed=7590361; DOI=10.1016/0378-1119(95)00504-y;
RA   Davis T., Shall S.;
RT   "Sequence of a chicken erythroblast mono(ADP-ribosyl)transferase-encoding
RT   gene and its upstream region.";
RL   Gene 164:371-372(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC         ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149,
CC         Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:142554; EC=2.4.2.31;
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X83676; CAA58649.1; -; Genomic_DNA.
DR   EMBL; X82397; CAA57793.1; -; mRNA.
DR   PIR; JC4367; JC4367.
DR   AlphaFoldDB; Q92080; -.
DR   SMR; Q92080; -.
DR   STRING; 9031.ENSGALP00000035605; -.
DR   VEuPathDB; HostDB:LOC121109081; -.
DR   eggNOG; ENOG502QUE9; Eukaryota.
DR   InParanoid; Q92080; -.
DR   PhylomeDB; Q92080; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0106274; F:NAD+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0018120; P:peptidyl-arginine ADP-ribosylation; IBA:GO_Central.
DR   InterPro; IPR000768; ART.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
DR   PROSITE; PS01291; ART; 1.
DR   PROSITE; PS51996; TR_MART; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycosyltransferase; NAD; NADP; Nucleotidyltransferase;
KW   Reference proteome; Signal; Transferase.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..300
FT                   /note="Erythroblast NAD(P)(+)--arginine ADP-
FT                   ribosyltransferase"
FT                   /id="PRO_0000019341"
FT   DOMAIN          70..256
FT                   /note="TR mART core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01340"
FT   REGION          276..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01340"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01340"
FT   ACT_SITE        224
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01340"
FT   BINDING         107
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         183
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..260
FT                   /evidence="ECO:0000250"
FT   DISULFID        159..208
FT                   /evidence="ECO:0000250"
FT   CONFLICT        60
FT                   /note="Q -> E (in Ref. 1; CAA58649)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="E -> K (in Ref. 1; CAA58649)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   300 AA;  34008 MW;  1D33BE2850D18158 CRC64;
     MEEPLLHAIL GLVLLLSTRT DASAARSKKG PIKEVVMDMA PHSFDDQYQG CIDLMEAELQ
     ELNRTEFANE TFAEGWRSAT EEWQRRWGRV SSPMVLRQDQ AIAVLAYTME GELYRVFNNA
     TLTAGRSRQH YLSSYPFKTL HFLLSRALHT LQESQTQPCH NVFRGVRGTR FTAQQGTVVR
     FGQFTSSSLQ KKVAEFFGLD TFFSVETCYG VPIKDLSTFP GEDEVLIPPF EQFRVTNSTY
     TAGRSFIQLR SQGKSSTYNC EFVKEKRCKE RPCAFSADKS SPLPRSPWPG WAPLAAPHSH