ID   NARFL_DANRE             Reviewed;         411 AA.
AC   A2RRV9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Cytosolic Fe-S cluster assembly factor narfl;
DE   AltName: Full=Nuclear prelamin A recognition factor-like protein;
GN   Name=narfl; ORFNames=zgc:158422;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA)
CC       complex, a multiprotein complex that mediates the incorporation of
CC       iron-sulfur cluster into extramitochondrial Fe/S proteins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; BC131874; AAI31875.1; -; mRNA.
DR   RefSeq; NP_001074460.2; NM_001080991.2.
DR   AlphaFoldDB; A2RRV9; -.
DR   SMR; A2RRV9; -.
DR   STRING; 7955.ENSDARP00000084112; -.
DR   PaxDb; A2RRV9; -.
DR   PeptideAtlas; A2RRV9; -.
DR   GeneID; 560541; -.
DR   KEGG; dre:560541; -.
DR   CTD; 560541; -.
DR   ZFIN; ZDB-GENE-070209-119; narfl.
DR   eggNOG; KOG2439; Eukaryota.
DR   InParanoid; A2RRV9; -.
DR   OrthoDB; 705416at2759; -.
DR   PhylomeDB; A2RRV9; -.
DR   PRO; PR:A2RRV9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Cytosolic Fe-S cluster assembly factor narfl"
FT                   /id="PRO_0000288489"
FT   BINDING         11
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         124
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         180
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         329
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         333
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  46099 MW;  3DD0C1193C758501 CRC64;
     MAVIFRSISG CITSAESVLI TQQSHEELYR VLRHNKQVSS TEQKVVVVSV SPQSRASLAA
     HYGIGSSEVA RKLTSFLKHL GVHHVFDTAF SRSFSLIESQ REFLQRFSQR EADKKALPML
     ASACPGWICY AEKTHGEFIL PYISTTRSPQ QIMGSLVKGY FASQKGVSPQ MIYHVTVMPC
     YDKKLEASRP DFYLSEHETR EVDCVITSGE VLKMLEEEKV SLRDVQPAPL DTMFSNVCGE
     ELLGHAGSGS GGYLHHIYKH AAKQLFGVDV DELTYKTMKN KDFQEVTLEK DGQVLLKFAA
     VYGFRNIQNL VQKLKRGKSP YHFVEVMACP SGCLNGGGQL KPSADQSNKE LLQQVEEVYR
     SEHPSVPEDD SQVAELYQSW LESVGEEKAR QLLHTQYHAV EKTANGLSIK W