ID   NARFL_XENTR             Reviewed;         476 AA.
AC   A8WH18;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Cytosolic Fe-S cluster assembly factor narfl;
DE   AltName: Full=Nuclear prelamin A recognition factor-like protein;
GN   Name=narfl;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=PopA;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA)
CC       complex, a multiprotein complex that mediates the incorporation of
CC       iron-sulfur cluster into extramitochondrial Fe/S proteins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; BC154937; AAI54938.1; -; mRNA.
DR   RefSeq; NP_001106557.1; NM_001113086.1.
DR   AlphaFoldDB; A8WH18; -.
DR   SMR; A8WH18; -.
DR   PaxDb; A8WH18; -.
DR   PRIDE; A8WH18; -.
DR   GeneID; 100127749; -.
DR   KEGG; xtr:100127749; -.
DR   CTD; 64428; -.
DR   Xenbase; XB-GENE-987594; ciao3.
DR   eggNOG; KOG2439; Eukaryota.
DR   InParanoid; A8WH18; -.
DR   OrthoDB; 705416at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Cytosolic Fe-S cluster assembly factor narfl"
FT                   /id="PRO_0000383692"
FT   BINDING         24
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         71
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         74
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         77
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         190
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         246
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         395
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         399
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   476 AA;  53495 MW;  00DB9712A607BBA2 CRC64;
     MASSFSGVLQ LTDLDDFIGP SQECIKPIKV EKKAGRAAAK IQIEDDGSYV QINPEGAARK
     LEKAKITLND CLACSGCVTS AETILITQQS HEELYKILKQ NKTENPLEHK VVVVSVSPQS
     WASLAARFNL IMQDTAQKLT AFFKQLGVHH VFDTNFSRNF SLLESQREFI QRFKRQKEDK
     KSLPMLASAC PGWICYAEKT HGSFILPYIS STKSPQQVMG SLVKSHFAKE KNLKPNQIYH
     VTVMPCYDKK LEASRPDFYN QEYETREVDC VITTGEVLRM LEQEGLSLSD VDPSPLDTLF
     GSAVQEEPVG HQGGGSGGYL EHVFRHAAQE LFGVHVDTVV YKPLKNKDFQ EVTLEQDGNV
     VLHFALAYGF RNIQNLVQKL KRGRCPYHYV EVMACPSGCL NGGGQIKAEG EGSKDLLQRV
     EDLYNTVRTE RPEEREEVAQ LYGDWLEDKD SAKARQALHT QYHAVEKINS GLTIKW