ID   NARF_BRUMA              Reviewed;         448 AA.
AC   A8PGQ3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Probable cytosolic Fe-S cluster assembly factor Bm1_25010;
GN   ORFNames=Bm1_25010;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
CC       assembly machinery. Required for maturation of extramitochondrial Fe/S
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; DS239177; EDP34689.1; -; Genomic_DNA.
DR   RefSeq; XP_001896462.1; XM_001896427.1.
DR   AlphaFoldDB; A8PGQ3; -.
DR   SMR; A8PGQ3; -.
DR   STRING; 6279.A8PGQ3; -.
DR   EnsemblMetazoa; Bm6838.1; Bm6838.1; WBGene00227099.
DR   GeneID; 6099904; -.
DR   KEGG; bmy:BM_BM6838; -.
DR   WBParaSite; Bm6838.1; Bm6838.1; WBGene00227099.
DR   CTD; 6099904; -.
DR   WormBase; Bm6838; BM02716; WBGene00227099; -.
DR   HOGENOM; CLU_018240_0_0_1; -.
DR   InParanoid; A8PGQ3; -.
DR   OMA; PHEQRAW; -.
DR   OrthoDB; 705416at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..448
FT                   /note="Probable cytosolic Fe-S cluster assembly factor
FT                   Bm1_25010"
FT                   /id="PRO_0000383693"
FT   BINDING         27
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         66
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         69
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         72
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         170
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         226
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         370
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         374
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   448 AA;  50073 MW;  5B5E392551509F25 CRC64;
     MNDDDFGFSG IIKIANVSDF IAPSQACILP LQSKESDVEV QIRVRSRAKK VDDSAVKKVE
     VTLKDCLACS GCITSAETIL IKEQSKPKFL EGLKKAQLSV MTVSPQSIAS IAYKRGCHLS
     EAARLIARIF MNMGMKYVVD SSFGRLLTLS LSYDEFKESQ LQRPIFTGVC PGFVCYAEKT
     HGTLLIPHIS CVRSPQAMMG ALVKDYLARK FNVRPEEIFH ASVMPCFDKK LEAARSHSEN
     HFNCREVDCV LSTGEVDAIL DECSSTESFP VDGKVGWLNA LENGKIISSE GGSSGGYAEY
     IVKRFVEESK TPLKLKRTIK DKNWEIIEAV DGETIVLSVA KCYGFRNIQN QVQKLKRSKC
     NYDYVEIMAC PSGCINGGGQ IRSASIEERK QLLDTIELPC SEDNSEMEEQ LERVKEEWSI
     LNPDWMNLLY TKYHAVVKSD ADRISTNW