NARF_DICDI
ID NARF_DICDI Reviewed; 522 AA.
AC Q54F30;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Probable cytosolic Fe-S cluster assembly factor narfl;
GN Name=narfl; ORFNames=DDB_G0291149;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
CC assembly machinery. Required for maturation of extramitochondrial Fe/S
CC proteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; AAFI02000175; EAL61858.1; -; Genomic_DNA.
DR RefSeq; XP_635360.1; XM_630268.1.
DR AlphaFoldDB; Q54F30; -.
DR SMR; Q54F30; -.
DR STRING; 44689.DDB0266484; -.
DR PaxDb; Q54F30; -.
DR PRIDE; Q54F30; -.
DR EnsemblProtists; EAL61858; EAL61858; DDB_G0291149.
DR GeneID; 8628008; -.
DR KEGG; ddi:DDB_G0291149; -.
DR dictyBase; DDB_G0291149; -.
DR eggNOG; KOG2439; Eukaryota.
DR HOGENOM; CLU_018240_0_0_1; -.
DR InParanoid; Q54F30; -.
DR OMA; PHEQRAW; -.
DR PhylomeDB; Q54F30; -.
DR PRO; PR:Q54F30; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..522
FT /note="Probable cytosolic Fe-S cluster assembly factor
FT narfl"
FT /id="PRO_0000328024"
FT BINDING 26
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 73
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 76
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 79
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 205
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 281
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 439
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 443
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 522 AA; 59422 MW; 23AE531C529C875E CRC64;
MSKGEDKFSS VLKLTEFDYI VPSQICIKPV EIEKSNDSGN SKIQIESDGR YVEISEDGTK
KSLEKATITL NDCLACSGCI TSAESVLITA QSISEFLLNV NNNNDSNNNQ DEKKTIVITL
SPQSRASLAS HFKISTLSVV KKLKTFFKKL NINYLFDSSF SRDFSLLESA AEFVARYKKT
YINNNNDEET GKLEPFPLPM LSSACPGWIC YAEKTHGEFI LPFISTTKSP QQIMGTLVKY
YFTEKILDNN TNNNNNNNNN NNNNNSKIKP SNIYHVTIMP CYDKKLEASR NDFYNDIFKT
KDVDCVLSTT EILDLFKEKE IDFLSLEEDN SIEEQFFQLS PSNQFYSING SSGGYLEFIY
KYAAKELFNV DIVEPIQYKI GRNQDFKEVS LEIDGKKVLN FAQAYGFRNI QNIVRKIKTN
ITTKKDTNSQ YDFVEIMACP SGCINGGGQI KSDAIKENKA ILLDSEEKYN ENVIFRQPID
NQSVQNIYNT WLNGCFSTDS KTNLHTQYHR IEKTTNALNI KW
