ID   NARF_DROGR              Reviewed;         476 AA.
AC   B4JBE6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Probable cytosolic Fe-S cluster assembly factor GH10760;
GN   ORFNames=GH10760;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
CC       assembly machinery. Required for maturation of extramitochondrial Fe/S
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; CH916368; EDW02951.1; -; Genomic_DNA.
DR   RefSeq; XP_001988084.1; XM_001988048.1.
DR   AlphaFoldDB; B4JBE6; -.
DR   SMR; B4JBE6; -.
DR   STRING; 7222.FBpp0144666; -.
DR   PRIDE; B4JBE6; -.
DR   EnsemblMetazoa; FBtr0146174; FBpp0144666; FBgn0118241.
DR   GeneID; 6561929; -.
DR   KEGG; dgr:6561929; -.
DR   eggNOG; KOG2439; Eukaryota.
DR   HOGENOM; CLU_018240_0_0_1; -.
DR   InParanoid; B4JBE6; -.
DR   OMA; PHEQRAW; -.
DR   OrthoDB; 705416at2759; -.
DR   PhylomeDB; B4JBE6; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Probable cytosolic Fe-S cluster assembly factor
FT                   GH10760"
FT                   /id="PRO_0000383701"
FT   BINDING         23
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         68
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         71
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         74
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         187
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         243
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         395
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         399
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   476 AA;  53719 MW;  06235521B0B45C6F CRC64;
     MSRFSGALQL TDLDDFITPS QECIKPVTID KTKSKTGAKI TVEADGYYEE SESGKQKLQK
     VEITLQDCLA CSGCITSAEG VLITQQSQEE LLKVLRENQT LKASGDNEQV RTIVFTISVQ
     PLLSLAHRYD LSLEEAGRHL AGYLQQLGAD YVLCTKIADD LALLECRQEF VERFRNNAEL
     SMLSSSCPGW VCYAEKTHGN FILPHIATTR SPQQIMGVLV KQLLAEKLGV SGSRIYHVTI
     MPCYDKKLEA SREDFYSEVS SSRDVDCVIT AIEVEQMLQA EEQTLQQFEP KDLHWPWTDQ
     QPESMLWAHE STMSGGYAEH IFKYAAKELF NEDTPTELQF RALRNRDFSE ICLEKEGKVL
     LKFAIANGFR NIQNLVQKLK RGKGPGYQFV EVMACPSGCI NGGAQVRPTT GQHVRQLTQQ
     LEELYKQLPR SNPDNTHTKQ IYADFFDGTH TDKSAQLLHT SYHAVEKLNT ALNIKW