NARF_DROSI
ID NARF_DROSI Reviewed; 477 AA.
AC B4NSS7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Probable cytosolic Fe-S cluster assembly factor GD17698;
GN ORFNames=GD17698;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
CC assembly machinery. Required for maturation of extramitochondrial Fe/S
CC proteins (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDX15259.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH982438; EDX15259.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_016025910.1; XM_016174411.1.
DR AlphaFoldDB; B4NSS7; -.
DR SMR; B4NSS7; -.
DR STRING; 7240.B4NSS7; -.
DR EnsemblMetazoa; FBtr0363172; FBpp0326733; FBgn0189247.
DR GeneID; 6739531; -.
DR Proteomes; UP000000304; Unassembled WGS sequence.
DR Bgee; FBgn0189247; Expressed in embryo and 3 other tissues.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT CHAIN 1..477
FT /note="Probable cytosolic Fe-S cluster assembly factor
FT GD17698"
FT /id="PRO_0000383707"
FT BINDING 23
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 68
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 71
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 74
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255"
FT BINDING 187
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 243
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 395
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
FT BINDING 399
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 477 AA; 54487 MW; 8DA67E4E23491A59 CRC64;
MSRLSTALQL TDIDDFITPS QICIKPVQID KARSKTGAKI KIKGDSCFEE SESGNLKLNK
VDISLQDCLA CSGCITSAEE VLITQQSQEE LLKVLQENSK NKASEDWDNV RTIVITLATQ
PILSLAHRYQ IGVEDAARHL NGYFRSLGAD YVLSTKVADD IALLECRQEF VDRYRENENL
TMLSSSCPGW VCYAEKTHGN FILPYVSTTR SPQQIMGVLV KQILADKINV PASRIYHVTV
MPCYDKKLEA SREDFFSKAN NSRDVDCVIT SVEVEQLLSE AQRPLSQYDL FDLDWPWSNV
RPEFMVWAHE KTLSGGYAEH IFKFAAKHIF NEDLTTELEF KQLRNRDFRE IILKQNGKTV
LKFAIANGFR NIQNLVQKLK REKLSNYHFV EVMACPSGCI NGGAQIRPTT GQHVRELTRK
LEELYHNLPR SEPENSLTKH IYNDFLDGFQ TDKSYEVLHT RYHDVVSDLS ISLNINW
