NARF_MOUSE
ID NARF_MOUSE Reviewed; 462 AA.
AC Q9CYQ7; Q8BVW9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Nuclear prelamin A recognition factor;
DE AltName: Full=Iron-only hydrogenase-like protein 2;
DE Short=IOP2;
GN Name=Narf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with LMNA and binds to the farnesylated C-terminal
CC domain. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR EMBL; AK013432; BAB28853.1; -; mRNA.
DR EMBL; AK076232; BAC36265.1; -; mRNA.
DR EMBL; AK081305; BAC38191.1; -; mRNA.
DR EMBL; AL808021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016090; AAH16090.1; -; mRNA.
DR CCDS; CCDS25772.1; -.
DR RefSeq; NP_080548.3; NM_026272.3.
DR AlphaFoldDB; Q9CYQ7; -.
DR SMR; Q9CYQ7; -.
DR STRING; 10090.ENSMUSP00000099304; -.
DR iPTMnet; Q9CYQ7; -.
DR PhosphoSitePlus; Q9CYQ7; -.
DR EPD; Q9CYQ7; -.
DR MaxQB; Q9CYQ7; -.
DR PaxDb; Q9CYQ7; -.
DR PeptideAtlas; Q9CYQ7; -.
DR PRIDE; Q9CYQ7; -.
DR ProteomicsDB; 287439; -.
DR Antibodypedia; 33014; 195 antibodies from 27 providers.
DR Ensembl; ENSMUST00000103015; ENSMUSP00000099304; ENSMUSG00000000056.
DR GeneID; 67608; -.
DR KEGG; mmu:67608; -.
DR UCSC; uc007mvq.2; mouse.
DR CTD; 26502; -.
DR MGI; MGI:1914858; Narf.
DR VEuPathDB; HostDB:ENSMUSG00000000056; -.
DR eggNOG; KOG2439; Eukaryota.
DR GeneTree; ENSGT00940000153514; -.
DR HOGENOM; CLU_018240_0_0_1; -.
DR InParanoid; Q9CYQ7; -.
DR OMA; CMRCIQV; -.
DR OrthoDB; 705416at2759; -.
DR PhylomeDB; Q9CYQ7; -.
DR TreeFam; TF106273; -.
DR BioGRID-ORCS; 67608; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Narf; mouse.
DR PRO; PR:Q9CYQ7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CYQ7; protein.
DR Bgee; ENSMUSG00000000056; Expressed in fetal liver hematopoietic progenitor cell and 243 other tissues.
DR Genevisible; Q9CYQ7; MM.
DR GO; GO:0005638; C:lamin filament; ISO:MGI.
DR GO; GO:0031981; C:nuclear lumen; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005521; F:lamin binding; ISO:MGI.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SUPFAM; SSF53920; SSF53920; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..462
FT /note="Nuclear prelamin A recognition factor"
FT /id="PRO_0000288480"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UHQ1"
FT CONFLICT 17
FT /note="T -> N (in Ref. 1; BAC36265)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 462 AA; 51816 MW; 55FD382E12FA2866 CRC64;
MKCEHCTRKE CSKKSKTDDQ ENVSSDGAQP SDGASPAKES EEKGEFHKLA DAKIFLSDCL
ACDSCVTVEE GVQLSQQSAK DFLHVLNLNK RCDTSKHRVL VVSVCPQSLP YFAAKFNLSV
TDASRRLCGF LKSLGVHYVF DTTIAADFSI LESQKEFVRR YHQHSEEQRE LPMLTSACPG
WVRYAERVLG RPIIPYLCTA KSPQQVMGSL VKDYFARQQN LSPEKIFHVV VAPCYDKKLE
ALREGLSTTL NGARGTDCVL TSGEIAQIME QSDLSVKDIA VDTLFGDMKE VAVQRHDGVS
SDGHLAHVFR HAAKELFGEH VEEITYRALR NKDFHEVTLE KNGEVLLRFA AAYGFRNIQN
MIQKLKKGKL PYHFVEVLAC PRGCLNGRGQ AQTEDGHTDR ALLQQMEGIY SGIPVRPPES
STHVQELYQE WLEGTESPKV QEVLHTSYQS LEPCTDGLDI KW
