ID   NARF_RAT                Reviewed;         456 AA.
AC   Q2YDU6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Nuclear prelamin A recognition factor;
DE   AltName: Full=Iron-only hydrogenase-like protein 2;
DE            Short=IOP2;
GN   Name=Narf;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with LMNA and binds to the farnesylated C-terminal
CC       domain. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}.
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DR   EMBL; BC110050; AAI10051.1; -; mRNA.
DR   RefSeq; NP_001034296.1; NM_001039207.2.
DR   AlphaFoldDB; Q2YDU6; -.
DR   SMR; Q2YDU6; -.
DR   STRING; 10116.ENSRNOP00000051803; -.
DR   PaxDb; Q2YDU6; -.
DR   GeneID; 360681; -.
DR   KEGG; rno:360681; -.
DR   CTD; 26502; -.
DR   RGD; 1310894; Narf.
DR   VEuPathDB; HostDB:ENSRNOG00000036664; -.
DR   eggNOG; KOG2439; Eukaryota.
DR   HOGENOM; CLU_018240_0_0_1; -.
DR   InParanoid; Q2YDU6; -.
DR   OMA; CMRCIQV; -.
DR   OrthoDB; 705416at2759; -.
DR   PRO; PR:Q2YDU6; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000036664; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q2YDU6; RN.
DR   GO; GO:0005638; C:lamin filament; ISO:RGD.
DR   GO; GO:0031981; C:nuclear lumen; ISO:RGD.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005521; F:lamin binding; ISO:RGD.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; SSF53920; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..456
FT                   /note="Nuclear prelamin A recognition factor"
FT                   /id="PRO_0000288481"
FT   REGION          12..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         29
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UHQ1"
SQ   SEQUENCE   456 AA;  51466 MW;  CB230FCF2E046118 CRC64;
     MKCEHCTRKE CSKKSKTDDQ ENVSVDVPSP AQENEEKGEF HKLADAKIFL SDCLACDSCV
     TVEEGVQLSQ QSAKDFFHVL NLNKRCDTSK HKVLVVSVCP QSLPYFAAKF NLSVTDASRR
     LCGFLKSLGV HYVFDTTIAA DFSILESQKE FVRRYHQHSE EQRELPMLTS ACPGWVRYAE
     RVLGRPIIPY LCTAKSPQQV MGSLVKDYFA RQQSLAPEKI FHIVVAPCYD KKLEALREGL
     SPTLNGARGT DCVLTSGEIA QIMEQSDLSV KDIAVDTLFG DVKEMAVRRH DGVSSDGHLA
     HVFRHAAKEL FGEHVEEITY RALRNKDFHE VTLEKNGEVL LRFAAAYGFR NIQNMIMKLK
     KGKFPYHFVE VLACPRGCLN GRGQAQTEDG HTDRALLQQM EGIYSGIPVW PPESSTHVQE
     LYQEWLEGTE SPKVQEVLHT SYQSLEPCTD SLDIKW