ID   NARPA_DANRE             Reviewed;         112 AA.
AC   Q7T3Y0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Notch-regulated ankyrin repeat-containing protein A;
GN   Name=nrarpa; ORFNames=zgc:100826;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=12711545; DOI=10.1016/s1567-133x(03)00009-7;
RA   Topczewska J.M., Topczewski J., Szostak A., Solnica-Krezel L.,
RA   Hogan B.L.M.;
RT   "Developmentally regulated expression of two members of the Nrarp family in
RT   zebrafish.";
RL   Gene Expr. Patterns 3:169-171(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tang M., Jiang Y.J.;
RT   "Cloning and functional analysis of two zebrafish nrarp genes.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=16228014; DOI=10.1038/ncb1311;
RA   Ishitani T., Matsumoto K., Chitnis A.B., Itoh M.;
RT   "Nrarp functions to modulate neural-crest-cell differentiation by
RT   regulating LEF1 protein stability.";
RL   Nat. Cell Biol. 7:1106-1112(2005).
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=19154719; DOI=10.1016/j.devcel.2008.12.009;
RA   Phng L.K., Potente M., Leslie J.D., Babbage J., Nyqvist D., Lobov I.,
RA   Ondr J.K., Rao S., Lang R.A., Thurston G., Gerhardt H.;
RT   "Nrarp coordinates endothelial Notch and Wnt signaling to control vessel
RT   density in angiogenesis.";
RL   Dev. Cell 16:70-82(2009).
CC   -!- FUNCTION: Regulates independently canonical Wnt and Notch signaling by
CC       modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal
CC       transcription factor in the Wnt signaling cascade, by blocking its
CC       ubiquitination. Involved in angiogenesis; involved in intersegmental
CC       vessel patterning during development. {ECO:0000269|PubMed:16228014,
CC       ECO:0000269|PubMed:19154719}.
CC   -!- DEVELOPMENTAL STAGE: First detected at low levels in the blastula stage
CC       and begins to accumulate in the margin of the blastoderm. At the shield
CC       stage, when gastrulation starts, expressed uniformly in the margin. As
CC       gastrulation proceeds, expressed at high levels in the posterior
CC       paraxial mesoderm. In the 1 day old embryo, at the early pharyngula
CC       stage, expression in the developing brain is very strong and expression
CC       is restricted to ventral domains of the brain. Expressed in endothelial
CC       cells of the intersegmantal vessels, between somite boundaries and in
CC       the dorsal aorta. {ECO:0000269|PubMed:12711545,
CC       ECO:0000269|PubMed:19154719}.
CC   -!- SIMILARITY: Belongs to the NRARP family. {ECO:0000305}.
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DR   EMBL; AY187047; AAO83388.1; -; mRNA.
DR   EMBL; AF509780; AAQ08001.1; -; mRNA.
DR   EMBL; BC077081; AAH77081.1; -; mRNA.
DR   RefSeq; NP_852472.1; NM_181495.3.
DR   AlphaFoldDB; Q7T3Y0; -.
DR   SMR; Q7T3Y0; -.
DR   STRING; 7955.ENSDARP00000112028; -.
DR   PaxDb; Q7T3Y0; -.
DR   Ensembl; ENSDART00000122657; ENSDARP00000112028; ENSDARG00000091419.
DR   Ensembl; ENSDART00000180568; ENSDARP00000150495; ENSDARG00000091419.
DR   Ensembl; ENSDART00000193039; ENSDARP00000145738; ENSDARG00000111485.
DR   GeneID; 353224; -.
DR   KEGG; dre:353224; -.
DR   CTD; 353224; -.
DR   ZFIN; ZDB-GENE-030515-6; nrarpa.
DR   eggNOG; KOG0505; Eukaryota.
DR   GeneTree; ENSGT00940000161928; -.
DR   HOGENOM; CLU_000134_41_1_1; -.
DR   InParanoid; Q7T3Y0; -.
DR   OMA; NMTSCEF; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q7T3Y0; -.
DR   PRO; PR:Q7T3Y0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000091419; Expressed in presomitic mesoderm and 27 other tissues.
DR   GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IMP:ZFIN.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:MGI.
DR   GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0050931; P:pigment cell differentiation; IMP:ZFIN.
DR   GO; GO:0022407; P:regulation of cell-cell adhesion; IMP:MGI.
DR   GO; GO:0002040; P:sprouting angiogenesis; IMP:MGI.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Developmental protein; Notch signaling pathway;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..112
FT                   /note="Notch-regulated ankyrin repeat-containing protein A"
FT                   /id="PRO_0000325081"
FT   REPEAT          48..77
FT                   /note="ANK 1"
FT   REPEAT          81..110
FT                   /note="ANK 2"
SQ   SEQUENCE   112 AA;  12246 MW;  D36DD024731D1591 CRC64;
     MSQADISTCS APQRVFQEAV KKGNTKELHS LLQNMTNCEF NVNSFGPEGQ TALHQSVIDG
     NLELVKLLVK FGADIRLANR EGWSALHIAA FGGHQDIVLY LITKAKYSSG AR