ID   NARPB_DANRE             Reviewed;         111 AA.
AC   Q7T3X9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Notch-regulated ankyrin repeat-containing protein B;
GN   Name=nrarpb; ORFNames=zgc:101875;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=12711545; DOI=10.1016/s1567-133x(03)00009-7;
RA   Topczewska J.M., Topczewski J., Szostak A., Solnica-Krezel L.,
RA   Hogan B.L.M.;
RT   "Developmentally regulated expression of two members of the Nrarp family in
RT   zebrafish.";
RL   Gene Expr. Patterns 3:169-171(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tang M., Jiang Y.J.;
RT   "Cloning and functional analysis of two zebrafish nrarp genes.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=16228014; DOI=10.1038/ncb1311;
RA   Ishitani T., Matsumoto K., Chitnis A.B., Itoh M.;
RT   "Nrarp functions to modulate neural-crest-cell differentiation by
RT   regulating LEF1 protein stability.";
RL   Nat. Cell Biol. 7:1106-1112(2005).
RN   [5]
RP   FUNCTION.
RX   PubMed=19154719; DOI=10.1016/j.devcel.2008.12.009;
RA   Phng L.K., Potente M., Leslie J.D., Babbage J., Nyqvist D., Lobov I.,
RA   Ondr J.K., Rao S., Lang R.A., Thurston G., Gerhardt H.;
RT   "Nrarp coordinates endothelial Notch and Wnt signaling to control vessel
RT   density in angiogenesis.";
RL   Dev. Cell 16:70-82(2009).
CC   -!- FUNCTION: Regulates independently canonical Wnt and Notch signaling by
CC       modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal
CC       transcription factor in the Wnt signaling cascade, by blocking its
CC       ubiquitination. Involved in angiogenesis; involved in intersegmental
CC       vessel patterning during development. {ECO:0000269|PubMed:16228014,
CC       ECO:0000269|PubMed:19154719}.
CC   -!- DEVELOPMENTAL STAGE: First detected at low levels in the blastula stage
CC       and begins to accumulate in the margin of the blastoderm. At the shield
CC       stage, when gastrulation starts, expression is higher on the dorsal
CC       site. As gastrulation proceeds, expressed at high levels in the
CC       anterior ectoderm. In the 1 day old embryo, at the early pharyngula
CC       stage, expression in the developing brain is very strong and expression
CC       extends in to the spinal cord. {ECO:0000269|PubMed:12711545}.
CC   -!- SIMILARITY: Belongs to the NRARP family. {ECO:0000305}.
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DR   EMBL; AY187048; AAO83389.1; -; mRNA.
DR   EMBL; AF509781; AAQ08002.1; -; mRNA.
DR   EMBL; BC085461; AAH85461.1; -; mRNA.
DR   RefSeq; NP_852473.1; NM_181496.5.
DR   AlphaFoldDB; Q7T3X9; -.
DR   SMR; Q7T3X9; -.
DR   STRING; 7955.ENSDARP00000003601; -.
DR   PaxDb; Q7T3X9; -.
DR   Ensembl; ENSDART00000022625; ENSDARP00000003601; ENSDARG00000018958.
DR   Ensembl; ENSDART00000183012; ENSDARP00000148883; ENSDARG00000018958.
DR   GeneID; 353225; -.
DR   KEGG; dre:353225; -.
DR   CTD; 353225; -.
DR   ZFIN; ZDB-GENE-030515-7; nrarpb.
DR   eggNOG; KOG0505; Eukaryota.
DR   GeneTree; ENSGT00940000161928; -.
DR   InParanoid; Q7T3X9; -.
DR   OMA; REAKCHS; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q7T3X9; -.
DR   PRO; PR:Q7T3X9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000018958; Expressed in tail bud paraxial mesoderm and 28 other tissues.
DR   ExpressionAtlas; Q7T3X9; baseline and differential.
DR   GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IMP:ZFIN.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:MGI.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0022407; P:regulation of cell-cell adhesion; IMP:MGI.
DR   GO; GO:0002040; P:sprouting angiogenesis; IMP:MGI.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Developmental protein; Notch signaling pathway;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..111
FT                   /note="Notch-regulated ankyrin repeat-containing protein B"
FT                   /id="PRO_0000325082"
FT   REPEAT          47..76
FT                   /note="ANK 1"
FT   REPEAT          80..109
FT                   /note="ANK 2"
SQ   SEQUENCE   111 AA;  12267 MW;  7B540548E15C2E00 CRC64;
     MSQADMTCSA RQRVFQEALR KGNTKELHSL LQNMTNCEFN VNSFGPEGQT ALHQSVIDGN
     LELVKLLVKF GADTRLANRD GWSALHIAAF GGHQDIVLYL ITRAKYSSSA L