NARP_ECOLI
ID NARP_ECOLI Reviewed; 215 AA.
AC P31802; Q2MAQ0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Nitrate/nitrite response regulator protein NarP;
GN Name=narP; OrderedLocusNames=b2193, JW2181;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8501030; DOI=10.1128/jb.175.11.3259-3268.1993;
RA Rabin R.S., Stewart V.;
RT "Dual response regulators (NarL and NarP) interact with dual sensors (NarX
RT and NarQ) to control nitrate- and nitrite-regulated gene expression in
RT Escherichia coli K-12.";
RL J. Bacteriol. 175:3259-3268(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RT "Automated multiplex sequencing of the E.coli genome.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: This protein activates the expression of the nitrate
CC reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and
CC represses the transcription of the fumarate reductase (frdABCD) operon
CC in response to a nitrate/nitrite induction signal transmitted by either
CC the NarX or NarQ proteins.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA16411.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L11273; AAA24200.1; -; Genomic_DNA.
DR EMBL; U00008; AAA16411.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC75253.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76656.1; -; Genomic_DNA.
DR PIR; A40584; A40584.
DR RefSeq; NP_416697.1; NC_000913.3.
DR RefSeq; WP_001113639.1; NZ_LN832404.1.
DR AlphaFoldDB; P31802; -.
DR SMR; P31802; -.
DR BioGRID; 4263485; 18.
DR BioGRID; 853322; 3.
DR DIP; DIP-10317N; -.
DR IntAct; P31802; 5.
DR STRING; 511145.b2193; -.
DR iPTMnet; P31802; -.
DR jPOST; P31802; -.
DR PaxDb; P31802; -.
DR PRIDE; P31802; -.
DR EnsemblBacteria; AAC75253; AAC75253; b2193.
DR EnsemblBacteria; BAE76656; BAE76656; BAE76656.
DR GeneID; 949081; -.
DR KEGG; ecj:JW2181; -.
DR KEGG; eco:b2193; -.
DR PATRIC; fig|1411691.4.peg.43; -.
DR EchoBASE; EB1489; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_000445_90_10_6; -.
DR InParanoid; P31802; -.
DR OMA; LDRFAPM; -.
DR PhylomeDB; P31802; -.
DR BioCyc; EcoCyc:NARP-MON; -.
DR PRO; PR:P31802; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IMP:EcoCyc.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:EcoCyc.
DR CDD; cd06170; LuxR_C_like; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; DNA-binding; Nitrate assimilation;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Repressor;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..215
FT /note="Nitrate/nitrite response regulator protein NarP"
FT /id="PRO_0000081149"
FT DOMAIN 8..124
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 147..212
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 171..190
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT MOD_RES 59
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 215 AA; 23575 MW; C7121668E3130956 CRC64;
MPEATPFQVM IVDDHPLMRR GVRQLLELDP GSEVVAEAGD GASAIDLANR LDIDVILLDL
NMKGMSGLDT LNALRRDGVT AQIIILTVSD ASSDVFALID AGADGYLLKD SDPEVLLEAI
RAGAKGSKVF SERVNQYLRE REMFGAEEDP FSVLTERELD VLHELAQGLS NKQIASVLNI
SEQTVKVHIR NLLRKLNVRS RVAATILFLQ QRGAQ
