ID   NARP_HAEIN              Reviewed;         208 AA.
AC   P44845;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Nitrate/nitrite response regulator protein homolog;
GN   Name=narP; OrderedLocusNames=HI_0726;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Could activate the expression of a formate dehydrogenase
CC       operon and could repress the transcription of the fumarate reductase
CC       (frdABCD) operon.
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DR   EMBL; L42023; AAC22384.1; -; Genomic_DNA.
DR   PIR; A64089; A64089.
DR   RefSeq; NP_438884.1; NC_000907.1.
DR   RefSeq; WP_005652269.1; NC_000907.1.
DR   AlphaFoldDB; P44845; -.
DR   SMR; P44845; -.
DR   STRING; 71421.HI_0726; -.
DR   EnsemblBacteria; AAC22384; AAC22384; HI_0726.
DR   KEGG; hin:HI_0726; -.
DR   PATRIC; fig|71421.8.peg.758; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_000445_90_10_6; -.
DR   OMA; LDRFAPM; -.
DR   PhylomeDB; P44845; -.
DR   BioCyc; HINF71421:G1GJ1-765-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..208
FT                   /note="Nitrate/nitrite response regulator protein homolog"
FT                   /id="PRO_0000081150"
FT   DOMAIN          6..122
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          142..207
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        166..185
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         57
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   208 AA;  23079 MW;  0B72119BEC4906C7 CRC64;
     MQDKLKVLLI DDHPLMRRGI KQLVELDDNF EVVADVSSGT EGISVALQTS PDVIILDLNM
     KGLSGLDTLK GLRAEGVDAR ILILTVSDAK NDIYTLIDAG ADGYLLKDTE PDTLLEQIKR
     IAQGEVILSD SIKNLLLERT HEDNPLDSLT DREMGVLRQI ATGLSNKQIA AQLFISEETV
     KVHIRNLLRK LNVHSRVAAT VLFFEQNR