NARR_HUMAN
ID NARR_HUMAN Reviewed; 198 AA.
AC P0DI83;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Ras-related protein Rab-34, isoform NARR;
DE AltName: Full=Nine amino-acid residue-repeats;
GN Name=RAB34; Synonyms=NARR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-26; 65-71; 74-109; 119-125; 128-145; 155-171 AND
RP 186-193, CLEAVAGE OF INITIATOR METHIONINE, REPEATS, SUBCELLULAR LOCATION,
RP INTERACTION WITH EIF5A AND ERF1, AND PHOSPHORYLATION AT SER-13; THR-69;
RP SER-78; SER-87; SER-96 AND SER-123.
RX PubMed=21586586; DOI=10.1093/nar/gkr273;
RA Zougman A., Mann M., Wisniewski J.R.;
RT "Identification and characterization of a novel ubiquitous nucleolar
RT protein 'NARR' encoded by a gene overlapping the rab34 oncogene.";
RL Nucleic Acids Res. 39:7103-7113(2011).
CC -!- SUBUNIT: May interact with EIF5A and ERF1.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21586586}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:21586586}. Note=Colocalizes with rDNA
CC clusters.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=NARR;
CC IsoId=P0DI83-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9BZG1-1; Sequence=External;
CC Name=2;
CC IsoId=Q9BZG1-2; Sequence=External;
CC Name=4;
CC IsoId=Q9BZG1-4; Sequence=External;
CC -!- PTM: Phosphorylated during M-phase. {ECO:0000269|PubMed:21586586}.
CC -!- CAUTION: Shares its exons with RAB34, but the first 5'-exon is longer,
CC and the translation occurs 443 base pairs upstream from RAB34
CC initiator, in another frame. May be produced by an alternative
CC promoter. {ECO:0000305}.
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DR EMBL; AC010761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CX872465; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001243210.1; NM_001256281.2. [P0DI83-1]
DR AlphaFoldDB; P0DI83; -.
DR BioGRID; 3188911; 6.
DR IntAct; P0DI83; 6.
DR iPTMnet; P0DI83; -.
DR PhosphoSitePlus; P0DI83; -.
DR SwissPalm; P0DI83; -.
DR BioMuta; RAB34; -.
DR DMDM; 347602360; -.
DR EPD; P0DI83; -.
DR jPOST; P0DI83; -.
DR MassIVE; P0DI83; -.
DR PeptideAtlas; P0DI83; -.
DR PRIDE; P0DI83; -.
DR ProteomicsDB; 52535; -. [P0DI83-1]
DR Antibodypedia; 14281; 127 antibodies from 26 providers.
DR DNASU; 83871; -.
DR Ensembl; ENST00000636154.2; ENSP00000490450.1; ENSG00000109113.20. [P0DI83-1]
DR GeneID; 83871; -.
DR CTD; 83871; -.
DR DisGeNET; 83871; -.
DR GeneCards; RAB34; -.
DR HGNC; HGNC:16519; RAB34.
DR HPA; ENSG00000109113; Low tissue specificity.
DR neXtProt; NX_P0DI83; -.
DR OpenTargets; ENSG00000109113; -.
DR VEuPathDB; HostDB:ENSG00000109113; -.
DR GeneTree; ENSGT00940000159645; -.
DR OrthoDB; 1048146at2759; -.
DR PathwayCommons; P0DI83; -.
DR SignaLink; P0DI83; -.
DR BioGRID-ORCS; 83871; 25 hits in 1081 CRISPR screens.
DR ChiTaRS; RAB34; human.
DR GenomeRNAi; 83871; -.
DR Pharos; P0DI83; Tbio.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000109113; Expressed in descending thoracic aorta and 174 other tissues.
DR ExpressionAtlas; P0DI83; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:21586586"
FT CHAIN 2..198
FT /note="Ras-related protein Rab-34, isoform NARR"
FT /id="PRO_0000412533"
FT REPEAT 7..15
FT /note="1"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 16..24
FT /note="2"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 25..33
FT /note="3"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 34..42
FT /note="4"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 43..51
FT /note="5"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 52..60
FT /note="6"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 61..69
FT /note="7"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 70..78
FT /note="8"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 79..87
FT /note="9"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 88..96
FT /note="10"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 97..105
FT /note="11"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 106..114
FT /note="12"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REPEAT 115..123
FT /note="13"
FT /evidence="ECO:0000269|PubMed:21586586"
FT REGION 7..125
FT /note="13 x 9 AA approximate tandem-repeats of P-R-V-I-V-G-
FT (S/T)-P-R"
FT REGION 37..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:21586586"
FT MOD_RES 69
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:21586586"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:21586586"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:21586586"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:21586586"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:21586586"
SQ SEQUENCE 198 AA; 21118 MW; E03CF9EB3272B766 CRC64;
MVGQPQPRDD VGSPRPRVIV GTIRPRVIVG TIRPRVIVGS ARARPPPDGT PRPQLAAEES
PRPRVIFGTP RARVILGSPR PRVIVSSPWP AVVVASPRPR TPVGSPWPRV VVGTPRPRVI
VGSPRARVAD ADPASAPSQG ALQGRRQDEH SGTRAEGSRP GGAAPVPEEG GRFARAQRLP
PPRHLRLPGA PDRHRGQI
