NART_STAEQ
ID NART_STAEQ Reviewed; 387 AA.
AC Q5HLK7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Probable nitrate transporter NarT;
GN Name=narT; Synonyms=narK; OrderedLocusNames=SERP1980;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Probably required for nitrate uptake under anoxic conditions.
CC Also possibly involved in excretion of nitrite produced by the
CC dissimilatory reduction of nitrate (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Positively regulated by the two-component system NreB/NreC.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Nitrate/nitrite porter (TC 2.A.1.8) family. {ECO:0000305}.
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DR EMBL; CP000029; AAW52893.1; -; Genomic_DNA.
DR RefSeq; WP_002438328.1; NC_002976.3.
DR AlphaFoldDB; Q5HLK7; -.
DR SMR; Q5HLK7; -.
DR STRING; 176279.SERP1980; -.
DR EnsemblBacteria; AAW52893; AAW52893; SERP1980.
DR KEGG; ser:SERP1980; -.
DR eggNOG; COG2223; Bacteria.
DR HOGENOM; CLU_001265_14_0_9; -.
DR OMA; DAWWFMF; -.
DR OrthoDB; 1217595at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015112; F:nitrate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd17341; MFS_NRT2_like; 1.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044772; NO3_transporter.
DR PANTHER; PTHR23515; PTHR23515; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Nitrate assimilation; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..387
FT /note="Probable nitrate transporter NarT"
FT /id="PRO_0000349402"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 387 AA; 41561 MW; 733474B3A70E4B48 CRC64;
MNMKKGVSQL TLQTLSLVAG FMAWSIISPL MPFISQDVDI SPGQISVILA IPVILGSVLR
VPFGYLTNIV GAKWVFFWSF IVLLLPIFLL GQAQSPGMLM LSGFFLGIGG AIFSVGVTSV
PKYFSKDKVG LANGIYGVGN IGTAVSSFCA PVLAGAIGWQ NTVRSYLIIL SIFAILMFFL
GDKNEPKVKI PLMAQVKDLS KNYKLYYLSL WYFITFGAFV AFGIFLPNFL VDHFSIDKVD
AGIRSGIFIA LATFLRPVGG VIGDKFNAVQ ALIIDFVIMI IGALILSLSS HIVLFTIGCL
AISICAGIGN GLIFKLAPSY FSKEAGSANG IVSMMGGLGG FFPPLVITFV TSITGSSHLA
FFFLAIFGVI ALITMIHLNK KEKAIRI
