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NAS4_ARATH
ID   NAS4_ARATH              Reviewed;         324 AA.
AC   Q9C7X5;
DT   13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Probable nicotianamine synthase 4;
DE            EC=2.5.1.43;
DE   AltName: Full=S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 4;
GN   Name=NAS4; OrderedLocusNames=At1g56430; ORFNames=F13N6.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC       sensor for the physiological iron status within the plant, and/or might
CC       be involved in the transport of iron. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC         methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC   -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC       {ECO:0000305}.
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DR   EMBL; AC058785; AAG51505.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33394.1; -; Genomic_DNA.
DR   EMBL; AY099758; AAM20609.1; -; mRNA.
DR   EMBL; AY128890; AAM91290.1; -; mRNA.
DR   PIR; B96606; B96606.
DR   RefSeq; NP_176038.1; NM_104521.3.
DR   AlphaFoldDB; Q9C7X5; -.
DR   SMR; Q9C7X5; -.
DR   BioGRID; 27321; 1.
DR   IntAct; Q9C7X5; 1.
DR   STRING; 3702.AT1G56430.1; -.
DR   iPTMnet; Q9C7X5; -.
DR   PaxDb; Q9C7X5; -.
DR   PRIDE; Q9C7X5; -.
DR   ProteomicsDB; 251300; -.
DR   DNASU; 842096; -.
DR   EnsemblPlants; AT1G56430.1; AT1G56430.1; AT1G56430.
DR   GeneID; 842096; -.
DR   Gramene; AT1G56430.1; AT1G56430.1; AT1G56430.
DR   KEGG; ath:AT1G56430; -.
DR   Araport; AT1G56430; -.
DR   TAIR; locus:2010718; AT1G56430.
DR   eggNOG; ENOG502QTU6; Eukaryota.
DR   HOGENOM; CLU_031919_1_1_1; -.
DR   InParanoid; Q9C7X5; -.
DR   OMA; SERMFFH; -.
DR   OrthoDB; 1009301at2759; -.
DR   PhylomeDB; Q9C7X5; -.
DR   BioCyc; ARA:AT1G56430-MON; -.
DR   PRO; PR:Q9C7X5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C7X5; baseline and differential.
DR   Genevisible; Q9C7X5; AT.
DR   GO; GO:0030410; F:nicotianamine synthase activity; IGI:TAIR.
DR   GO; GO:0030418; P:nicotianamine biosynthetic process; IGI:TAIR.
DR   GO; GO:0010233; P:phloem transport; IGI:TAIR.
DR   GO; GO:0009555; P:pollen development; IGI:TAIR.
DR   GO; GO:0009860; P:pollen tube growth; IGI:TAIR.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR004298; Nicotian_synth.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR32266; PTHR32266; 1.
DR   Pfam; PF03059; NAS; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51142; NAS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..324
FT                   /note="Probable nicotianamine synthase 4"
FT                   /id="PRO_0000212703"
SQ   SEQUENCE   324 AA;  36352 MW;  5893FDB230E00C30 CRC64;
     MGYCQDDQLV NKICDLYEKI SKLETLKPCE DVDTLFKQLV STCIPPNPNI DVTKMSENIQ
     EMRSNLIKIC GEAEGYLEHH FSSILTSFED NPLHHLNLFP YYNNYLKLSK LEFDLLEQNL
     NGFVPRTVAF IGSGPLPLTS VVLASSHLKD SIFHNFDIDP SANMVAARLV SSDPDLSQRM
     FFHTVDIMDV TESLKGFDVV FLAALVGMDK KEKVKVVEHL EKHMSPGALL MLRSAHGPRA
     FLYPIVEPCD LEGFEVLSVY HPTDEVINSI VISRKLGEDA NGVVHDHIDQ ASDLACNCSK
     IHVIMNKKKS IIEEFAGANE EQLT
 
 
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