ID   NASLL_YERPE             Reviewed;         265 AA.
AC   Q8D035; Q74VP5;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=L-histidine 2-aminobutanoyltransferase {ECO:0000305|PubMed:29618515};
DE            EC=2.5.1.- {ECO:0000305|PubMed:29618515};
DE   AltName: Full=Nicotianamine synthase-like enzyme;
DE            Short=NAS;
GN   Name=smtA3 {ECO:0000312|EMBL:AAS61493.1};
GN   OrderedLocusNames=y2836 {ECO:0000312|EMBL:AAM86387.1},
GN   YP_1250 {ECO:0000312|EMBL:AAS61493.1};
GN   ORFNames=NCTC144_04063 {ECO:0000312|EMBL:SUQ38696.1};
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC144;
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=29618515; DOI=10.1074/jbc.ra118.002007;
RA   McFarlane J.S., Davis C.L., Lamb A.L.;
RT   "Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural
RT   and kinetic analysis of a new functional class of opine dehydrogenase.";
RL   J. Biol. Chem. 293:8009-8019(2018).
CC   -!- FUNCTION: Catalyzes the nucleophilic attack of one alpha-aminobutanoate
CC       moiety from SAM onto L-histidine to produce the intermediate (2S)-2-
CC       amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate.
CC       Functions in the biosynthesis of the metallophore yersinopine, which is
CC       involved in metal acquisition and thus enables bacterial growth inside
CC       the host, where metal access is limited. Therefore, this enzyme
CC       probably contributes to Yersinia virulence.
CC       {ECO:0000305|PubMed:29618515}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-
CC         1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-
CC         methyl-5'-thioadenosine; Xref=Rhea:RHEA:59780, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:57595, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:143196; Evidence={ECO:0000305|PubMed:29618515};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59781;
CC         Evidence={ECO:0000305|PubMed:29618515};
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. CntL family.
CC       {ECO:0000305}.
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DR   EMBL; AE009952; AAM86387.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS61493.1; -; Genomic_DNA.
DR   EMBL; UHIZ01000002; SUQ38696.1; -; Genomic_DNA.
DR   RefSeq; WP_002211374.1; NZ_WUCM01000027.1.
DR   AlphaFoldDB; Q8D035; -.
DR   SMR; Q8D035; -.
DR   IntAct; Q8D035; 1.
DR   STRING; 214092.YPO1346; -.
DR   DNASU; 1147783; -.
DR   EnsemblBacteria; AAM86387; AAM86387; y2836.
DR   EnsemblBacteria; AAS61493; AAS61493; YP_1250.
DR   EnsemblBacteria; SUQ38696; SUQ38696; NCTC144_04063.
DR   GeneID; 57977142; -.
DR   KEGG; ypk:y2836; -.
DR   KEGG; ypm:YP_1250; -.
DR   PATRIC; fig|632.151.peg.219; -.
DR   HOGENOM; CLU_089313_0_0_6; -.
DR   OMA; EARMQFS; -.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0030410; F:nicotianamine synthase activity; IEA:InterPro.
DR   GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR004298; Nicotian_synth.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR32266; PTHR32266; 1.
DR   Pfam; PF03059; NAS; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..265
FT                   /note="L-histidine 2-aminobutanoyltransferase"
FT                   /id="PRO_0000447037"
SQ   SEQUENCE   265 AA;  29686 MW;  34D224B3E0E75E0A CRC64;
     MYTLMKADVL AQLAGLQQEI SQLHDNAQQN QSHFVLLERR FSRLQSFNDE PQLQDYRLQL
     EHDDAVVKQI AQLRQVANAA LCDYEKHQVC ALCSPSSKTD DYLTSFNQSL QQEIKLAGMQ
     MGEKVLLVGS GALPTTALVL VAKLGATVFC YDHDPAAQQL ARQLVQSLGL EKQVQFIDNL
     KELTDRPVDH IIVASLVADK QALLAQLVPY VTRSSKLVMR YGNGLKSIFN CPYCHEVNCS
     HWRTASKPVT TGLYDLIILE PNHHA