NAT10_ARATH
ID NAT10_ARATH Reviewed; 541 AA.
AC O04472;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Putative nucleobase-ascorbate transporter 10;
DE Short=AtNAT10;
GN Name=NAT10; OrderedLocusNames=At1g65550; ORFNames=F5I14.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=16982705; DOI=10.1093/pcp/pcl011;
RA Maurino V.G., Grube E., Zielinski J., Schild A., Fischer K., Flugge U.-I.;
RT "Identification and expression analysis of twelve members of the
RT nucleobase-ascorbate transporter (NAT) gene family in Arabidopsis
RT thaliana.";
RL Plant Cell Physiol. 47:1381-1393(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC001229; AAB60909.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34395.1; -; Genomic_DNA.
DR PIR; D96680; D96680.
DR RefSeq; NP_176733.2; NM_105229.2.
DR AlphaFoldDB; O04472; -.
DR SMR; O04472; -.
DR STRING; 3702.AT1G65550.1; -.
DR PaxDb; O04472; -.
DR PRIDE; O04472; -.
DR EnsemblPlants; AT1G65550.1; AT1G65550.1; AT1G65550.
DR GeneID; 842866; -.
DR Gramene; AT1G65550.1; AT1G65550.1; AT1G65550.
DR KEGG; ath:AT1G65550; -.
DR Araport; AT1G65550; -.
DR TAIR; locus:2034104; AT1G65550.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_3_1; -.
DR InParanoid; O04472; -.
DR OMA; WEKFSLY; -.
DR OrthoDB; 387031at2759; -.
DR PhylomeDB; O04472; -.
DR PRO; PR:O04472; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04472; baseline and differential.
DR Genevisible; O04472; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..541
FT /note="Putative nucleobase-ascorbate transporter 10"
FT /id="PRO_0000270167"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 541 AA; 60348 MW; A34C526D3E76B72F CRC64;
MTNGGGGNNG AANRTEELQP HPVKEQLPGI QYCVNSPPPW LEAVVLGFQH YLLSLGITVL
IPSVLVPLMG GGYAEKVKVI QTLLFVSGLT TLFQSFFGTR LPVIAVASYA YIIPITSIIY
STRFTYYTDP FERFVRTMRS IQGALIITGC FQVLICILGV WRNIVRFLSP LSIAPLATFT
GLGLYHIGFP LLARCVEVGL PGLILLIFVT QYLPRFLKMK KGVMILDGSR CDRYGMILCI
PLVWLFAQLL TSSGVYDHKS HTTQTSCRTD RTGLITNTPW IYIPYPFQWG SPTFDITDSF
AMMAASFVTL FESTGLFYAS ARYGSATPIP PSVVSRGTCW LGVGVLLNGM LGGITGITTS
TENVGLLAMT KIGSRRVIQI SAAFMIFFSI FGKFGAFFAS IPLPIMASLY CIVLCFVSSV
GLSYLQFCNL NSFNIKFILG FSFFMAISIP QYFREYYNGG WRSDHHSNWL EDMIRVIFMS
HTTVAAIIAI VLDCTLCRDS DEAKKDCGMK WWDKFRLYNL DVRNDEFYGL PCRLNKFFPS
H
