NAT14_HUMAN
ID NAT14_HUMAN Reviewed; 206 AA.
AC Q8WUY8; Q8TDY7; Q9NS72;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable N-acetyltransferase 14;
DE EC=2.3.1.- {ECO:0000305};
DE AltName: Full=K562 cell-derived leucine-zipper-like protein 1;
GN Name=NAT14; Synonyms=KLP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DNA-BINDING, AND TISSUE
RP SPECIFICITY.
RX PubMed=10873651; DOI=10.1006/bbrc.2000.2991;
RA Takahashi S., Furuyama K., Kobayashi A., Taketani S., Harigae H.,
RA Yamamoto M., Igarashi K., Sasaki T., Hayashi N.;
RT "Cloning of a coproporphyrinogen oxidase promoter regulatory element
RT binding protein.";
RL Biochem. Biophys. Res. Commun. 273:596-602(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11779635; DOI=10.1016/s0167-4781(01)00349-9;
RA Takahashi S., Harigae H., Yokoyama H., Kaku M., Sasaki T.;
RT "Genomic structure and regulation of a novel human gene, Klp1.";
RL Biochim. Biophys. Acta 1522:207-211(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable acetyltransferase. {ECO:0000305}.
CC -!- FUNCTION: May act as a transcription factor that regulates the
CC expression of coproporphyrinogen oxidase by binding to a promoter
CC regulatory element. {ECO:0000269|PubMed:10873651}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in K-562 and HeLa cell lines and in
CC brain. {ECO:0000269|PubMed:10873651}.
CC -!- SIMILARITY: Belongs to the camello family. {ECO:0000305}.
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DR EMBL; AB038651; BAB03716.1; -; mRNA.
DR EMBL; AB055059; BAB85857.1; -; Genomic_DNA.
DR EMBL; BC019079; AAH19079.1; -; mRNA.
DR CCDS; CCDS12926.1; -.
DR PIR; JC7320; JC7320.
DR RefSeq; NP_065111.1; NM_020378.3.
DR AlphaFoldDB; Q8WUY8; -.
DR BioGRID; 121372; 85.
DR IntAct; Q8WUY8; 29.
DR MINT; Q8WUY8; -.
DR STRING; 9606.ENSP00000205194; -.
DR GlyGen; Q8WUY8; 1 site, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q8WUY8; -.
DR SwissPalm; Q8WUY8; -.
DR BioMuta; NAT14; -.
DR DMDM; 74730785; -.
DR EPD; Q8WUY8; -.
DR jPOST; Q8WUY8; -.
DR MassIVE; Q8WUY8; -.
DR MaxQB; Q8WUY8; -.
DR PaxDb; Q8WUY8; -.
DR PeptideAtlas; Q8WUY8; -.
DR PRIDE; Q8WUY8; -.
DR ProteomicsDB; 74727; -.
DR Antibodypedia; 33111; 90 antibodies from 17 providers.
DR DNASU; 57106; -.
DR Ensembl; ENST00000205194.5; ENSP00000205194.3; ENSG00000090971.5.
DR GeneID; 57106; -.
DR KEGG; hsa:57106; -.
DR MANE-Select; ENST00000205194.5; ENSP00000205194.3; NM_020378.4; NP_065111.1.
DR UCSC; uc002qle.3; human.
DR CTD; 57106; -.
DR DisGeNET; 57106; -.
DR GeneCards; NAT14; -.
DR HGNC; HGNC:28918; NAT14.
DR HPA; ENSG00000090971; Low tissue specificity.
DR neXtProt; NX_Q8WUY8; -.
DR OpenTargets; ENSG00000090971; -.
DR PharmGKB; PA162396977; -.
DR VEuPathDB; HostDB:ENSG00000090971; -.
DR eggNOG; ENOG502RYNT; Eukaryota.
DR GeneTree; ENSGT00950000182932; -.
DR HOGENOM; CLU_127402_0_0_1; -.
DR InParanoid; Q8WUY8; -.
DR OMA; RWHRRQG; -.
DR OrthoDB; 1318443at2759; -.
DR PhylomeDB; Q8WUY8; -.
DR TreeFam; TF336981; -.
DR PathwayCommons; Q8WUY8; -.
DR SignaLink; Q8WUY8; -.
DR BioGRID-ORCS; 57106; 12 hits in 1087 CRISPR screens.
DR ChiTaRS; NAT14; human.
DR GenomeRNAi; 57106; -.
DR Pharos; Q8WUY8; Tbio.
DR PRO; PR:Q8WUY8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WUY8; protein.
DR Bgee; ENSG00000090971; Expressed in right hemisphere of cerebellum and 155 other tissues.
DR ExpressionAtlas; Q8WUY8; baseline and differential.
DR Genevisible; Q8WUY8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; NAS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; NAS:UniProtKB.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 1: Evidence at protein level;
KW Activator; Acyltransferase; DNA-binding; Membrane; Reference proteome;
KW Transcription; Transcription regulation; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..206
FT /note="Probable N-acetyltransferase 14"
FT /id="PRO_0000307786"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 6..206
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
FT CONFLICT 21..24
FT /note="Missing (in Ref. 2; BAB85857)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="A -> V (in Ref. 1; BAB03716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 206 AA; 21650 MW; EA8CF3AD64627970 CRC64;
MAPSHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA ASSGLRFVLA
SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA VRGSGDVCGV LALAPGTNAG
DGARVTRLSV SRWHRRRGVG RRLLAFAEAR ARAWAGGMGE PRARLVVPVA VAAWGVGGML
EGCGYQAEGG WGCLGYTLVR EFSKDL
