ID   NAT14_MOUSE             Reviewed;         206 AA.
AC   Q8BVG8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Probable N-acetyltransferase 14;
DE            EC=2.3.1.- {ECO:0000305};
GN   Name=Nat14;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Visual cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Probable acetyltransferase that binds the 5'-GGACTACAG-3'
CC       sequence of coproporphyrinogen oxidase promoter. Able to activate
CC       transcription of a reporter construct in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: Probable acetyltransferase. {ECO:0000305}.
CC   -!- FUNCTION: May act as a transcription factor regulating the expression
CC       of coproporphyrinogen oxidase by binding to a promoter regulatory
CC       element. {ECO:0000250|UniProtKB:Q8WUY8}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the camello family. {ECO:0000305}.
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DR   EMBL; AK078272; BAC37199.1; -; mRNA.
DR   EMBL; AK158627; BAE34587.1; -; mRNA.
DR   EMBL; BC047219; AAH47219.1; -; mRNA.
DR   CCDS; CCDS20749.1; -.
DR   RefSeq; NP_958743.1; NM_201355.3.
DR   RefSeq; XP_006540078.1; XM_006540015.3.
DR   RefSeq; XP_006540080.1; XM_006540017.1.
DR   RefSeq; XP_006540081.1; XM_006540018.1.
DR   RefSeq; XP_006540082.1; XM_006540019.3.
DR   RefSeq; XP_006540083.1; XM_006540020.1.
DR   RefSeq; XP_006540084.1; XM_006540021.1.
DR   AlphaFoldDB; Q8BVG8; -.
DR   STRING; 10090.ENSMUSP00000045354; -.
DR   iPTMnet; Q8BVG8; -.
DR   PhosphoSitePlus; Q8BVG8; -.
DR   SwissPalm; Q8BVG8; -.
DR   MaxQB; Q8BVG8; -.
DR   PaxDb; Q8BVG8; -.
DR   PeptideAtlas; Q8BVG8; -.
DR   PRIDE; Q8BVG8; -.
DR   ProteomicsDB; 287606; -.
DR   Antibodypedia; 33111; 90 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000047309; ENSMUSP00000045354; ENSMUSG00000035285.
DR   Ensembl; ENSMUST00000207687; ENSMUSP00000147229; ENSMUSG00000035285.
DR   GeneID; 269854; -.
DR   KEGG; mmu:269854; -.
DR   UCSC; uc009eyy.2; mouse.
DR   CTD; 57106; -.
DR   MGI; MGI:3039561; Nat14.
DR   VEuPathDB; HostDB:ENSMUSG00000035285; -.
DR   eggNOG; ENOG502RYNT; Eukaryota.
DR   GeneTree; ENSGT00950000182932; -.
DR   HOGENOM; CLU_127402_0_0_1; -.
DR   InParanoid; Q8BVG8; -.
DR   OMA; RWHRRQG; -.
DR   OrthoDB; 1543328at2759; -.
DR   PhylomeDB; Q8BVG8; -.
DR   TreeFam; TF336981; -.
DR   BioGRID-ORCS; 269854; 0 hits in 77 CRISPR screens.
DR   ChiTaRS; Nat14; mouse.
DR   PRO; PR:Q8BVG8; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8BVG8; protein.
DR   Bgee; ENSMUSG00000035285; Expressed in dentate gyrus of hippocampal formation granule cell and 202 other tissues.
DR   ExpressionAtlas; Q8BVG8; baseline and differential.
DR   Genevisible; Q8BVG8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   1: Evidence at protein level;
KW   Activator; Acyltransferase; DNA-binding; Membrane; Reference proteome;
KW   Transcription; Transcription regulation; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Probable N-acetyltransferase 14"
FT                   /id="PRO_0000307788"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..206
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   206 AA;  21778 MW;  B3CF212CB5A9C1FE CRC64;
     MAPNHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA ASSGLRFILA
     SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA VRGSGDVCGV LALAPGANVG
     DGARVTRLSV SRWHRRRGVG RRLLAFAEAR ARAWAGSMGE PRARLVVPVA VAAWGVAGLL
     EACGYQAEGG WGCMGYMLVR EFSKDL