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NAT1_ARATH
ID   NAT1_ARATH              Reviewed;         520 AA.
AC   Q9SHZ3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Nucleobase-ascorbate transporter 1;
DE            Short=AtNAT1;
GN   Name=NAT1; OrderedLocusNames=At2g05760; ORFNames=T25M19.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=16982705; DOI=10.1093/pcp/pcl011;
RA   Maurino V.G., Grube E., Zielinski J., Schild A., Fischer K., Flugge U.-I.;
RT   "Identification and expression analysis of twelve members of the
RT   nucleobase-ascorbate transporter (NAT) gene family in Arabidopsis
RT   thaliana.";
RL   Plant Cell Physiol. 47:1381-1393(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons 4 days after imbibition
CC       (DAI). Expressed in the minor and major veins of cotyledons and leaves,
CC       in the shoot apex and pedicels. Expressed in the root meristems, root
CC       tips and lateral root primordia. {ECO:0000269|PubMed:16982705}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
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DR   EMBL; AC007233; AAD26910.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05969.1; -; Genomic_DNA.
DR   EMBL; BT023436; AAY56427.1; -; mRNA.
DR   PIR; D84471; D84471.
DR   RefSeq; NP_178636.1; NM_126592.3.
DR   AlphaFoldDB; Q9SHZ3; -.
DR   SMR; Q9SHZ3; -.
DR   STRING; 3702.AT2G05760.1; -.
DR   PaxDb; Q9SHZ3; -.
DR   PRIDE; Q9SHZ3; -.
DR   ProteomicsDB; 251249; -.
DR   EnsemblPlants; AT2G05760.1; AT2G05760.1; AT2G05760.
DR   GeneID; 815127; -.
DR   Gramene; AT2G05760.1; AT2G05760.1; AT2G05760.
DR   KEGG; ath:AT2G05760; -.
DR   Araport; AT2G05760; -.
DR   TAIR; locus:2060076; AT2G05760.
DR   eggNOG; KOG1292; Eukaryota.
DR   HOGENOM; CLU_017959_5_3_1; -.
DR   InParanoid; Q9SHZ3; -.
DR   OMA; WANEMPL; -.
DR   OrthoDB; 387031at2759; -.
DR   PhylomeDB; Q9SHZ3; -.
DR   PRO; PR:Q9SHZ3; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SHZ3; baseline and differential.
DR   Genevisible; Q9SHZ3; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   InterPro; IPR029948; NAT1/2.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR11119:SF106; PTHR11119:SF106; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..520
FT                   /note="Nucleobase-ascorbate transporter 1"
FT                   /id="PRO_0000270158"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   520 AA;  57131 MW;  20CF2827A8FE8C97 CRC64;
     MAEISHPPME QLQDLEYCID SNPPWPETVL LAFQNYILML GTSAFIPALL VPAMGGSDGD
     RARVIQTLLF VAGIKTLLQA LFGTRLPAVV GGSLAYVVPI AYIINDSSLQ KISNDHERFI
     HTMRAIQGAL IVASSIQIIL GYSQVWGLFS RFFSPLGMAP VVGLVGLGMF QRGFPQLGNC
     IEIGLPMLLL VIGLTQYLKH VRPFKDVPIF ERFPILICVT IVWIYAVILT ASGAYRGKPS
     LTQHSCRTDK ANLISTAPWF KFPYPLQWGP PTFSVGHSFA MMSAVLVSMV ESTGAYIAAS
     RLAIATPPPA YVLSRGIGWQ GIGVLLDGLF GTGTGSTVLV ENVGLLGLTR VGSRRVVQVS
     AGFMIVFSTL GKFGAVFASI PVPIYAALHC ILFGLVAAVG LSFLQFTNMN SMRNLMITGL
     SLFLGISIPQ FFAQYWDARH YGLVHTNAGW FNAFLNTLFM SPATVGLIIA VFMDNTMEVE
     RSKKDRGMPW WVKFRTFRGD NRNEEFYTLP FNLNRFFPPT
 
 
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