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NAT5_ARATH
ID   NAT5_ARATH              Reviewed;         528 AA.
AC   Q8RWE9; Q9FGR4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Nucleobase-ascorbate transporter 5;
DE            Short=AtNAT5;
GN   Name=NAT5; OrderedLocusNames=At5g49990; ORFNames=K9P8.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=16982705; DOI=10.1093/pcp/pcl011;
RA   Maurino V.G., Grube E., Zielinski J., Schild A., Fischer K., Flugge U.-I.;
RT   "Identification and expression analysis of twelve members of the
RT   nucleobase-ascorbate transporter (NAT) gene family in Arabidopsis
RT   thaliana.";
RL   Plant Cell Physiol. 47:1381-1393(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Weakly expressed in the vasculature of developing
CC       leaves. {ECO:0000269|PubMed:16982705}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
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DR   EMBL; AB024032; BAB08803.1; -; Genomic_DNA.
DR   EMBL; AB026650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED95881.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69095.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69096.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69097.1; -; Genomic_DNA.
DR   EMBL; AY093137; AAM13136.1; -; mRNA.
DR   EMBL; BT008887; AAP68326.1; -; mRNA.
DR   EMBL; AK229752; BAF01588.1; -; mRNA.
DR   RefSeq; NP_001330797.1; NM_001344866.1.
DR   RefSeq; NP_001330798.1; NM_001344868.1.
DR   RefSeq; NP_001330799.1; NM_001344867.1.
DR   RefSeq; NP_199810.2; NM_124378.6.
DR   AlphaFoldDB; Q8RWE9; -.
DR   SMR; Q8RWE9; -.
DR   BioGRID; 20309; 6.
DR   IntAct; Q8RWE9; 6.
DR   STRING; 3702.AT5G49990.1; -.
DR   PaxDb; Q8RWE9; -.
DR   PRIDE; Q8RWE9; -.
DR   ProteomicsDB; 251050; -.
DR   EnsemblPlants; AT5G49990.1; AT5G49990.1; AT5G49990.
DR   EnsemblPlants; AT5G49990.2; AT5G49990.2; AT5G49990.
DR   EnsemblPlants; AT5G49990.3; AT5G49990.3; AT5G49990.
DR   EnsemblPlants; AT5G49990.4; AT5G49990.4; AT5G49990.
DR   GeneID; 835063; -.
DR   Gramene; AT5G49990.1; AT5G49990.1; AT5G49990.
DR   Gramene; AT5G49990.2; AT5G49990.2; AT5G49990.
DR   Gramene; AT5G49990.3; AT5G49990.3; AT5G49990.
DR   Gramene; AT5G49990.4; AT5G49990.4; AT5G49990.
DR   KEGG; ath:AT5G49990; -.
DR   Araport; AT5G49990; -.
DR   TAIR; locus:2158829; AT5G49990.
DR   eggNOG; KOG1292; Eukaryota.
DR   HOGENOM; CLU_017959_5_3_1; -.
DR   InParanoid; Q8RWE9; -.
DR   OMA; IHTGARW; -.
DR   OrthoDB; 387031at2759; -.
DR   PhylomeDB; Q8RWE9; -.
DR   PRO; PR:Q8RWE9; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8RWE9; baseline and differential.
DR   Genevisible; Q8RWE9; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..528
FT                   /note="Nucleobase-ascorbate transporter 5"
FT                   /id="PRO_0000270162"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  57321 MW;  C39B34A71260E9EF CRC64;
     MSAPKSGGDP LPHPPKEQLP DISYCITSPP PWPEAVLLGF QHYLVMLGTT VLIPSALVPQ
     MGGRNEEKAK LIQTILFVAG LNTLLQTVFG TRLPAVIGAS YTFVPVTISI MLSGRFNDVA
     DPVERFKRII RATQGALIVA STLQIILGFS GLWRNVVRFL SPLSAAPLVG LVGYGLYELG
     FPGVAKCIEI GLPGLIILIL ISQYMPHVIK GGKHVFARFA VIFSVAIVWL YAFFLTLGGA
     YNGVGTDTQR SCRTDRAGLI SAAPWIRVPW PFQWGAPLFD AGEAFAMMMA SFVALVESTG
     AFIAVSRYAS ATMPPPSVIS RGVGWQGVAI LISGLFGTGI GSSVSVENAG LLALTKIGSR
     RVVQISAGFM IFFSILGKFG AVFASIPSPI IAALYCLFFA YVGAGGLSLL QFCNLNSFRT
     LFILGFSIFL GLSIPQYFNE HTAIKGYGPV HTGARWFNDM VNVPFSSKAF VGGCVAYLLD
     TTLHKKDGSI RKDRGKHWWD RFWTFKNDPR TEEFYALPFN LNKYFPSV
 
 
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