NAT7_ARATH
ID NAT7_ARATH Reviewed; 538 AA.
AC Q0WPE9; Q9ZUJ0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Nucleobase-ascorbate transporter 7;
DE Short=AtNAT7;
GN Name=NAT7; OrderedLocusNames=At1g60030; ORFNames=T2K10.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16982705; DOI=10.1093/pcp/pcl011;
RA Maurino V.G., Grube E., Zielinski J., Schild A., Fischer K., Flugge U.-I.;
RT "Identification and expression analysis of twelve members of the
RT nucleobase-ascorbate transporter (NAT) gene family in Arabidopsis
RT thaliana.";
RL Plant Cell Physiol. 47:1381-1393(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16982705};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16982705}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in ovules.
CC {ECO:0000269|PubMed:16982705}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD14479.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005966; AAD14479.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33651.1; -; Genomic_DNA.
DR EMBL; AK229125; BAF01000.1; -; mRNA.
DR PIR; F96624; F96624.
DR RefSeq; NP_176211.2; NM_104695.5.
DR AlphaFoldDB; Q0WPE9; -.
DR SMR; Q0WPE9; -.
DR STRING; 3702.AT1G60030.1; -.
DR PaxDb; Q0WPE9; -.
DR PRIDE; Q0WPE9; -.
DR ProteomicsDB; 236811; -.
DR EnsemblPlants; AT1G60030.1; AT1G60030.1; AT1G60030.
DR GeneID; 842297; -.
DR Gramene; AT1G60030.1; AT1G60030.1; AT1G60030.
DR KEGG; ath:AT1G60030; -.
DR Araport; AT1G60030; -.
DR TAIR; locus:2202700; AT1G60030.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_3_1; -.
DR InParanoid; Q0WPE9; -.
DR OMA; RFMSFKS; -.
DR OrthoDB; 387031at2759; -.
DR PhylomeDB; Q0WPE9; -.
DR PRO; PR:Q0WPE9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q0WPE9; baseline and differential.
DR Genevisible; Q0WPE9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..538
FT /note="Nucleobase-ascorbate transporter 7"
FT /id="PRO_0000270164"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 376
FT /note="S -> P (in Ref. 3; BAF01000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 538 AA; 58508 MW; D9CA6C5433DD4F56 CRC64;
MAGGGGGGGG VAPPLKHDGL EPHPVKDQLS SISYCITSPP PWPEAILLGF QHYLVMLGTT
VLIPTYLVPQ MGGGNEEKAK MVQTLLFVSG LNTLLQSFFG TRLPAVIGGS YTYVPTTLSI
ILAGRYSDIL DPQEKFKRIM RGIQGALIVA SILQIVVGFS GLWRNVVRLL SPLSAVPLVA
LAGFGLYEHG FPLLAKCIEI GLPEIILLLL FSQYIPHLIR GERQVFHRFA VIFSVVIVWI
YAHLLTVGGA YKNTGVNTQT SCRTDRSGLI SGSPWIRVPY PFQWGPPTFH AGEAFAMMAV
SFVSLIESTG TYIVVSRFAS ATPPPPSVLS RGVGWQGVGV LLCGLFGAGN GASVSVENAG
LLALTRVGSR RVVQISAGFM IFFSILGKFG AIFASIPAPV VAALHCLFFA YVGAGGLSLL
QFCNLNSFRT KFILGFSVFM GLSIPQYFNQ YTAVNKYGPV HTHARWFNDM INVPFSSKAF
VAGILAFFLD VTMSSKDSAT RKDRGMFWWD RFMSFKSDTR SEEFYSLPFN LNKYFPSV
