NATD1_HUMAN
ID NATD1_HUMAN Reviewed; 113 AA.
AC Q8N6N6; A8MWQ7; B3KX70;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein NATD1;
DE AltName: Full=N-acetyltransferase domain-containing protein 1;
GN Name=NATD1; Synonyms=C17orf103, GTLF3B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N6N6; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-8656665, EBI-10173507;
CC Q8N6N6; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-8656665, EBI-747204;
CC Q8N6N6; Q0VD86: INCA1; NbExp=3; IntAct=EBI-8656665, EBI-6509505;
CC Q8N6N6; Q9GZT8: NIF3L1; NbExp=6; IntAct=EBI-8656665, EBI-740897;
CC Q8N6N6; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8656665, EBI-79165;
CC Q8N6N6; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-8656665, EBI-949255;
CC Q8N6N6; Q12933: TRAF2; NbExp=3; IntAct=EBI-8656665, EBI-355744;
CC Q8N6N6; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-8656665, EBI-743265;
CC -!- SIMILARITY: Belongs to the NATD1 family. {ECO:0000305}.
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DR EMBL; AK126856; BAG54382.1; -; mRNA.
DR EMBL; AC087294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029527; AAH29527.1; -; mRNA.
DR RefSeq; NP_690878.2; NM_152914.2.
DR AlphaFoldDB; Q8N6N6; -.
DR SMR; Q8N6N6; -.
DR BioGRID; 129155; 13.
DR IntAct; Q8N6N6; 10.
DR MINT; Q8N6N6; -.
DR STRING; 9606.ENSP00000478388; -.
DR iPTMnet; Q8N6N6; -.
DR PhosphoSitePlus; Q8N6N6; -.
DR BioMuta; NATD1; -.
DR DMDM; 206729869; -.
DR EPD; Q8N6N6; -.
DR MassIVE; Q8N6N6; -.
DR MaxQB; Q8N6N6; -.
DR PaxDb; Q8N6N6; -.
DR PeptideAtlas; Q8N6N6; -.
DR PRIDE; Q8N6N6; -.
DR ProteomicsDB; 72207; -.
DR Antibodypedia; 75937; 6 antibodies from 5 providers.
DR DNASU; 256302; -.
DR Ensembl; ENST00000611551.1; ENSP00000478388.1; ENSG00000274180.1.
DR GeneID; 256302; -.
DR KEGG; hsa:256302; -.
DR MANE-Select; ENST00000611551.1; ENSP00000478388.1; NM_152914.3; NP_690878.2.
DR UCSC; uc032exx.2; human.
DR CTD; 256302; -.
DR DisGeNET; 256302; -.
DR GeneCards; NATD1; -.
DR HGNC; HGNC:30770; NATD1.
DR HPA; ENSG00000274180; Tissue enhanced (skeletal).
DR neXtProt; NX_Q8N6N6; -.
DR OpenTargets; ENSG00000274180; -.
DR PharmGKB; PA164716941; -.
DR VEuPathDB; HostDB:ENSG00000274180; -.
DR eggNOG; ENOG502S2NM; Eukaryota.
DR GeneTree; ENSGT00390000014840; -.
DR HOGENOM; CLU_132888_1_1_1; -.
DR InParanoid; Q8N6N6; -.
DR OMA; LSIHHDQ; -.
DR OrthoDB; 1593361at2759; -.
DR PhylomeDB; Q8N6N6; -.
DR PathwayCommons; Q8N6N6; -.
DR SignaLink; Q8N6N6; -.
DR BioGRID-ORCS; 256302; 3 hits in 198 CRISPR screens.
DR ChiTaRS; NATD1; human.
DR GenomeRNAi; 256302; -.
DR Pharos; Q8N6N6; Tdark.
DR PRO; PR:Q8N6N6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N6N6; protein.
DR Bgee; ENSG00000274180; Expressed in tibialis anterior and 154 other tissues.
DR Genevisible; Q8N6N6; HS.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR045057; Gcn5-rel_NAT.
DR InterPro; IPR031165; GNAT_YJDJ.
DR PANTHER; PTHR31435; PTHR31435; 1.
DR Pfam; PF14542; Acetyltransf_CG; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS51729; GNAT_YJDJ; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..113
FT /note="Protein NATD1"
FT /id="PRO_0000320656"
FT DOMAIN 22..112
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
FT VARIANT 42
FT /note="V -> I (in dbSNP:rs12449311)"
FT /id="VAR_062227"
FT CONFLICT 65
FT /note="R -> S (in Ref. 3; AAH29527)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 13032 MW; 0FCD9E0D48885379 CRC64;
MAHSAAAVPL GALEQGCPIR VEHDRRRRQF TVRLNGCHDR AVLLYEYVGK RIVDLQHTEV
PDAYRGRGIA KHLAKAALDF VVEEDLKAHL TCWYIQKYVK ENPLPQYLER LQP
