NATD1_MOUSE
ID NATD1_MOUSE Reviewed; 110 AA.
AC Q9DBW3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein NATD1;
DE AltName: Full=Gene trap locus protein F3-2;
DE AltName: Full=Gene trap locus protein F3b;
DE AltName: Full=N-acetyltransferase domain-containing protein 1;
GN Name=Natd1; Synonyms=Gm16515, Gtlf3b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10402672;
RX DOI=10.1002/(sici)1520-6408(1999)25:1<49::aid-dvg6>3.0.co;2-s;
RA Cannon J.P., Colicos S.M., Belmont J.W.;
RT "Gene trap screening using negative selection: identification of two
RT tandem, differentially expressed loci with potential hematopoietic
RT function.";
RL Dev. Genet. 25:49-63(1999).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in the heart, testis, kidney and lung.
CC {ECO:0000269|PubMed:10402672}.
CC -!- DEVELOPMENTAL STAGE: Detected at multiple sites in embryonic day 10.5
CC embryos, including the genital ridges, the aortic endothelium and
CC endothelium-associated cell clusters within the aortic lumen.
CC {ECO:0000269|PubMed:10402672}.
CC -!- SIMILARITY: Belongs to the NATD1 family. {ECO:0000305}.
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DR EMBL; AK004720; BAB23503.1; -; mRNA.
DR EMBL; AK080453; BAC37922.1; -; mRNA.
DR EMBL; AK089179; BAC40780.1; -; mRNA.
DR EMBL; AL603830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034332; AAH34332.1; -; mRNA.
DR EMBL; BC038816; AAH38816.1; -; mRNA.
DR CCDS; CCDS24802.1; -.
DR RefSeq; NP_079570.1; NM_025294.5.
DR AlphaFoldDB; Q9DBW3; -.
DR SMR; Q9DBW3; -.
DR STRING; 10090.ENSMUSP00000019075; -.
DR iPTMnet; Q9DBW3; -.
DR PhosphoSitePlus; Q9DBW3; -.
DR REPRODUCTION-2DPAGE; Q9DBW3; -.
DR EPD; Q9DBW3; -.
DR MaxQB; Q9DBW3; -.
DR PaxDb; Q9DBW3; -.
DR PRIDE; Q9DBW3; -.
DR ProteomicsDB; 252779; -.
DR Antibodypedia; 75937; 6 antibodies from 5 providers.
DR DNASU; 24083; -.
DR Ensembl; ENSMUST00000019075; ENSMUSP00000019075; ENSMUSG00000018931.
DR GeneID; 24083; -.
DR KEGG; mmu:24083; -.
DR UCSC; uc007jgu.2; mouse.
DR CTD; 256302; -.
DR MGI; MGI:1344388; Natd1.
DR VEuPathDB; HostDB:ENSMUSG00000018931; -.
DR eggNOG; ENOG502S2NM; Eukaryota.
DR GeneTree; ENSGT00390000014840; -.
DR HOGENOM; CLU_132888_1_1_1; -.
DR InParanoid; Q9DBW3; -.
DR OMA; LSIHHDQ; -.
DR OrthoDB; 1593361at2759; -.
DR PhylomeDB; Q9DBW3; -.
DR TreeFam; TF314063; -.
DR BioGRID-ORCS; 24083; 1 hit in 66 CRISPR screens.
DR PRO; PR:Q9DBW3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DBW3; protein.
DR Bgee; ENSMUSG00000018931; Expressed in animal zygote and 253 other tissues.
DR Genevisible; Q9DBW3; MM.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR045057; Gcn5-rel_NAT.
DR InterPro; IPR031165; GNAT_YJDJ.
DR PANTHER; PTHR31435; PTHR31435; 1.
DR Pfam; PF14542; Acetyltransf_CG; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS51729; GNAT_YJDJ; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..110
FT /note="Protein NATD1"
FT /id="PRO_0000320657"
FT DOMAIN 19..109
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ SEQUENCE 110 AA; 12731 MW; A98C9C2B503D149A CRC64;
MAHATPPSAL EQGGPIRVEH DRQRRQFSVR LNGCHDRAVL LYEYVGKRIV DLQHTEVPDA
YRGRGIAKHL AKAALDFVVE EDLKAHLTCW YIQKYVKENP LPQYLERLQP
