NAUT_NAUMA
ID NAUT_NAUMA Reviewed; 316 AA.
AC P86702;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 12.
DE RecName: Full=Nautilin-63 {ECO:0000303|PubMed:21585656};
DE Short=N63 {ECO:0000303|PubMed:21585656};
DE Flags: Fragments;
OS Nautilus macromphalus (Bellybutton nautilus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Nautiloidea; Nautilida; Nautilidae; Nautilus.
OX NCBI_TaxID=34576;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP GLYCOSYLATION.
RC TISSUE=Nacre {ECO:0000269|PubMed:21585656};
RX PubMed=21585656; DOI=10.1111/j.1742-4658.2011.08129.x;
RA Marie B., Zanella-Cleon I., Corneillat M., Becchi M., Alcaraz G.,
RA Plasseraud L., Luquet G., Marin F.;
RT "Nautilin-63, a novel acidic glycoprotein from the shell nacre of Nautilus
RT macromphalus.";
RL FEBS J. 278:2117-2130(2011).
CC -!- FUNCTION: Involved in nacre formation. Affects morphology of calcite
CC crystals in vitro but does not inhibit their formation. Binds chitin.
CC {ECO:0000269|PubMed:21585656}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21585656}.
CC -!- TISSUE SPECIFICITY: Component of the acid-soluble organic matrix of
CC nacreous shell layers (at protein level).
CC {ECO:0000269|PubMed:21585656}.
CC -!- PTM: Glycosylated; contains mainly glucose, galactose, galactosamine,
CC glucosamine and glucuronic acid. {ECO:0000269|PubMed:21585656}.
CC -!- CAUTION: The order of the peptides shown is unknown.
CC {ECO:0000269|PubMed:21585656}.
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DR AlphaFoldDB; P86702; -.
DR PRIDE; P86702; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0008061; F:chitin binding; IDA:UniProtKB.
DR GO; GO:0031215; P:shell calcification; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Chitin-binding; Direct protein sequencing; Glycoprotein; Secreted.
FT CHAIN <1..>316
FT /note="Nautilin-63"
FT /id="PRO_0000398789"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 1
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 4
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 11
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 14
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 21
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 22
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 31
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 36
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 38
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 50
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 58
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 61
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 63
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 81
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 86
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 88
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 102
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 141
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 179
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 185
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 214
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 232
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 236
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 241
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 244
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 248
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 256
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 276
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 286
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 300
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 307
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT UNSURE 310
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:21585656"
FT NON_CONS 8..9
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 16..17
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 25..26
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 33..34
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 41..42
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 52..53
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 60..61
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 69..70
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 78..79
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 87..88
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 97..98
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 108..109
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 118..119
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 130..131
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 142..143
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 154..155
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 166..167
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 180..181
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 191..192
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 201..202
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 217..218
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 233..234
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 247..248
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 261..262
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 278..279
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_CONS 298..299
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_TER 1
FT /evidence="ECO:0000303|PubMed:21585656"
FT NON_TER 316
FT /evidence="ECO:0000303|PubMed:21585656"
SQ SEQUENCE 316 AA; 32939 MW; D4462C09D9309291 CRC64;
IPDLASSRST LPVLTKGPTG LLGPRGPYGP LQRFNIELSA RGPAAVVGVL GKSFDSWLTK
LGLPGPQGRP GPPGPGCRFA LSNQCIKLAV EFAGQSKFSS FLANEGKKEG PEGEEGPRTE
FDGAYFAGGK FPVVGKPFPQ LKVFHAEPPF PTSRSTYGPS GSQPGKKGVV TPFKGNQPLK
FNDFLVESDS RCPPDDSSFE RSPAVSGHSS PATLNSRMKP AGFPGKGNGA PLKNGIASDP
LENLKNRLGS CFPDVLDEPP TSPFFTGPSG YTSDGLNKTP TVSKTLTAAG DPGPGAGKVL
ESSKTDLVAL QGEFQR
