NAV2_HUMAN
ID NAV2_HUMAN Reviewed; 2488 AA.
AC Q8IVL1; A6NEC1; Q8IVK3; Q8IVK4; Q8IVK5; Q8IVK6; Q8IVK7; Q8IVK8; Q8NHC9;
AC Q8NHD0; Q8TDE9; Q8TDF0; Q8TEB3; Q96B30; Q9NUZ6; Q9NVM7; Q9P2C8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Neuron navigator 2;
DE EC=3.6.4.12;
DE AltName: Full=Helicase APC down-regulated 1;
DE AltName: Full=Pore membrane and/or filament-interacting-like protein 2;
DE AltName: Full=Retinoic acid inducible in neuroblastoma 1;
DE AltName: Full=Steerin-2;
DE AltName: Full=Unc-53 homolog 2;
DE Short=unc53H2;
GN Name=NAV2; Synonyms=HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), INDUCTION BY ATRA, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND VARIANT ALA-1077.
RX PubMed=11904404; DOI=10.1073/pnas.052017399;
RA Merrill R.A., Plum L.A., Kaiser M.E., Clagett-Dame M.;
RT "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in
RT neuroblastoma cells and embryos.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:3422-3427(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION,
RP FUNCTION AS A HELICASE, INDUCTION, TISSUE SPECIFICITY, AND VARIANTS LYS-109
RP AND ALA-1077.
RX PubMed=12214280; DOI=10.1038/sj.onc.1205751;
RA Ishiguro H., Shimokawa T., Tsunoda T., Tanaka T., Fujii Y., Nakamura Y.,
RA Furukawa Y.;
RT "Isolation of HELAD1, a novel human helicase gene up-regulated in
RT colorectal carcinomas.";
RL Oncogene 21:6387-6394(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9; 10; 11; 12 AND 13), FUNCTION,
RP AND VARIANTS LYS-109 AND ALA-1077.
RX PubMed=15158073; DOI=10.1016/j.devbrainres.2004.03.004;
RA Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P.,
RA Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E.;
RT "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-
RT 53.";
RL Brain Res. Dev. Brain Res. 150:89-101(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-1077.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [5]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [6]
RP SEQUENCE REVISION.
RA Ohara O.;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7), AND VARIANTS
RP ASP-1041; ALA-1077 AND ILE-2374.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), AND VARIANT ALA-1077.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12062803; DOI=10.1016/s0378-1119(02)00567-x;
RA Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O.,
RA Christiansen H., Poustka A.;
RT "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is
RT predominantly expressed in the nervous system and encodes different protein
RT isoforms.";
RL Gene 290:73-94(2002).
RN [11]
RP ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RX PubMed=12079279; DOI=10.1006/geno.2002.6799;
RA Maes T., Barcelo A., Buesa C.;
RT "Neuron navigator: a human gene family with homology to unc-53, a cell
RT guidance gene from Caenorhabditis elegans.";
RL Genomics 80:21-30(2002).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1977, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1480; SER-1484; SER-1488 AND
RP SER-1977, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [15]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [17]
RP STRUCTURE BY NMR OF 90-197.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the CH domain from human neuron navigator 2.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: Possesses 3' to 5' helicase activity and exonuclease
CC activity. Involved in neuronal development, specifically in the
CC development of different sensory organs. {ECO:0000269|PubMed:12214280,
CC ECO:0000269|PubMed:15158073}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- INTERACTION:
CC Q8IVL1; Q7Z6V5: ADAT2; NbExp=3; IntAct=EBI-741200, EBI-2809203;
CC Q8IVL1; Q5T655: CFAP58; NbExp=3; IntAct=EBI-741200, EBI-10245749;
CC Q8IVL1; Q9UNL4: ING4; NbExp=3; IntAct=EBI-741200, EBI-2866661;
CC Q8IVL1; Q8WYH8: ING5; NbExp=4; IntAct=EBI-741200, EBI-488533;
CC Q8IVL1; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-741200, EBI-399246;
CC Q8IVL1; O75928: PIAS2; NbExp=4; IntAct=EBI-741200, EBI-348555;
CC Q8IVL1; Q96T37: RBM15; NbExp=3; IntAct=EBI-741200, EBI-2514922;
CC Q8IVL1; Q8NDT2: RBM15B; NbExp=3; IntAct=EBI-741200, EBI-726721;
CC Q8IVL1; Q8NDT2-2: RBM15B; NbExp=3; IntAct=EBI-741200, EBI-10269922;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12214280}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=13;
CC Comment=Additional isoforms may exist.;
CC Name=1;
CC IsoId=Q8IVL1-1; Sequence=Displayed;
CC Name=2; Synonyms=RAINB1d;
CC IsoId=Q8IVL1-2; Sequence=VSP_021934, VSP_021937;
CC Name=3; Synonyms=HELAD1L;
CC IsoId=Q8IVL1-3; Sequence=VSP_021934, VSP_021937, VSP_021938;
CC Name=4; Synonyms=HELAD1S;
CC IsoId=Q8IVL1-4; Sequence=VSP_021927, VSP_021934, VSP_021937,
CC VSP_021938;
CC Name=5;
CC IsoId=Q8IVL1-5; Sequence=VSP_021926, VSP_021935, VSP_021936,
CC VSP_021937, VSP_021938;
CC Name=6;
CC IsoId=Q8IVL1-6; Sequence=VSP_021925, VSP_021937, VSP_021938;
CC Name=7;
CC IsoId=Q8IVL1-7; Sequence=VSP_021924;
CC Name=8;
CC IsoId=Q8IVL1-8; Sequence=VSP_021932;
CC Name=9;
CC IsoId=Q8IVL1-9; Sequence=VSP_021933;
CC Name=10;
CC IsoId=Q8IVL1-10; Sequence=VSP_021928;
CC Name=11;
CC IsoId=Q8IVL1-11; Sequence=VSP_021929;
CC Name=12;
CC IsoId=Q8IVL1-12; Sequence=VSP_021930;
CC Name=13;
CC IsoId=Q8IVL1-13; Sequence=VSP_021931;
CC -!- TISSUE SPECIFICITY: Highly expressed in the brain, kidney and liver.
CC Also expressed in the thyroid, mammary gland, spinal cord, heart,
CC placenta and lung. Abundantly expressed in colon cancers.
CC {ECO:0000269|PubMed:11904404, ECO:0000269|PubMed:12062803,
CC ECO:0000269|PubMed:12079279, ECO:0000269|PubMed:12214280}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in the nervous system of
CC developing embryos. Also expressed in fetal heart, liver and kidney.
CC {ECO:0000269|PubMed:11904404}.
CC -!- INDUCTION: By all-trans retinoic acid (ATRA). Up-regulated in
CC colorectal carcinomas. {ECO:0000269|PubMed:11904404,
CC ECO:0000269|PubMed:12214280}.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
CC -!- CAUTION: PubMed:15158073 experiments have been carried out in mouse.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92657.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB85038.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF466143; AAL96479.1; -; mRNA.
DR EMBL; AF466144; AAL96480.1; -; mRNA.
DR EMBL; AB063115; BAC00853.1; -; mRNA.
DR EMBL; AB063116; BAC00854.1; -; mRNA.
DR EMBL; AJ488102; CAD32471.1; -; mRNA.
DR EMBL; AJ488203; CAD32556.1; -; mRNA.
DR EMBL; AJ488204; CAD32557.1; -; mRNA.
DR EMBL; AJ488205; CAD32558.1; -; mRNA.
DR EMBL; AJ488206; CAD32559.1; -; mRNA.
DR EMBL; AJ488207; CAD32560.1; -; mRNA.
DR EMBL; AJ488208; CAD32561.1; -; mRNA.
DR EMBL; AB037840; BAA92657.3; ALT_INIT; mRNA.
DR EMBL; AK001495; BAA91723.1; -; mRNA.
DR EMBL; AK001892; BAA91965.1; -; mRNA.
DR EMBL; AK074287; BAB85038.1; ALT_FRAME; mRNA.
DR EMBL; AC009549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC015684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC111163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016054; AAH16054.1; -; mRNA.
DR CCDS; CCDS44552.1; -. [Q8IVL1-5]
DR CCDS; CCDS53612.1; -. [Q8IVL1-4]
DR CCDS; CCDS58126.1; -. [Q8IVL1-1]
DR CCDS; CCDS7850.1; -. [Q8IVL1-3]
DR CCDS; CCDS7851.2; -. [Q8IVL1-2]
DR RefSeq; NP_001104488.1; NM_001111018.1. [Q8IVL1-4]
DR RefSeq; NP_001104489.1; NM_001111019.2. [Q8IVL1-5]
DR RefSeq; NP_001231892.1; NM_001244963.1. [Q8IVL1-1]
DR RefSeq; NP_660093.2; NM_145117.4. [Q8IVL1-3]
DR RefSeq; NP_892009.3; NM_182964.5. [Q8IVL1-2]
DR RefSeq; XP_006718431.1; XM_006718368.3. [Q8IVL1-5]
DR RefSeq; XP_011518754.1; XM_011520452.2.
DR PDB; 2YRN; NMR; -; A=90-197.
DR PDBsum; 2YRN; -.
DR AlphaFoldDB; Q8IVL1; -.
DR SMR; Q8IVL1; -.
DR BioGRID; 124606; 29.
DR IntAct; Q8IVL1; 13.
DR MINT; Q8IVL1; -.
DR STRING; 9606.ENSP00000379396; -.
DR CarbonylDB; Q8IVL1; -.
DR GlyConnect; 1961; 13 N-Linked glycans (7 sites).
DR GlyGen; Q8IVL1; 8 sites, 15 N-linked glycans (7 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q8IVL1; -.
DR PhosphoSitePlus; Q8IVL1; -.
DR BioMuta; NAV2; -.
DR DMDM; 308153582; -.
DR EPD; Q8IVL1; -.
DR jPOST; Q8IVL1; -.
DR MassIVE; Q8IVL1; -.
DR MaxQB; Q8IVL1; -.
DR PaxDb; Q8IVL1; -.
DR PeptideAtlas; Q8IVL1; -.
DR PRIDE; Q8IVL1; -.
DR ProteomicsDB; 70724; -. [Q8IVL1-1]
DR ProteomicsDB; 70725; -. [Q8IVL1-10]
DR ProteomicsDB; 70726; -. [Q8IVL1-11]
DR ProteomicsDB; 70727; -. [Q8IVL1-12]
DR ProteomicsDB; 70728; -. [Q8IVL1-13]
DR ProteomicsDB; 70729; -. [Q8IVL1-2]
DR ProteomicsDB; 70730; -. [Q8IVL1-3]
DR ProteomicsDB; 70731; -. [Q8IVL1-4]
DR ProteomicsDB; 70732; -. [Q8IVL1-5]
DR ProteomicsDB; 70733; -. [Q8IVL1-6]
DR ProteomicsDB; 70734; -. [Q8IVL1-7]
DR ProteomicsDB; 70735; -. [Q8IVL1-8]
DR ProteomicsDB; 70736; -. [Q8IVL1-9]
DR Antibodypedia; 2148; 105 antibodies from 25 providers.
DR DNASU; 89797; -.
DR Ensembl; ENST00000349880.9; ENSP00000309577.6; ENSG00000166833.23. [Q8IVL1-3]
DR Ensembl; ENST00000360655.8; ENSP00000353871.4; ENSG00000166833.23. [Q8IVL1-4]
DR Ensembl; ENST00000396085.6; ENSP00000379394.1; ENSG00000166833.23. [Q8IVL1-2]
DR Ensembl; ENST00000396087.7; ENSP00000379396.3; ENSG00000166833.23. [Q8IVL1-1]
DR Ensembl; ENST00000533917.5; ENSP00000437316.1; ENSG00000166833.23. [Q8IVL1-5]
DR GeneID; 89797; -.
DR KEGG; hsa:89797; -.
DR MANE-Select; ENST00000349880.9; ENSP00000309577.6; NM_145117.5; NP_660093.2. [Q8IVL1-3]
DR UCSC; uc001mpp.4; human. [Q8IVL1-1]
DR CTD; 89797; -.
DR DisGeNET; 89797; -.
DR GeneCards; NAV2; -.
DR HGNC; HGNC:15997; NAV2.
DR HPA; ENSG00000166833; Tissue enhanced (brain, heart muscle).
DR MIM; 607026; gene.
DR neXtProt; NX_Q8IVL1; -.
DR OpenTargets; ENSG00000166833; -.
DR PharmGKB; PA31452; -.
DR VEuPathDB; HostDB:ENSG00000166833; -.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR GeneTree; ENSGT00940000155663; -.
DR HOGENOM; CLU_001002_1_1_1; -.
DR InParanoid; Q8IVL1; -.
DR OMA; SSIYSTX; -.
DR OrthoDB; 21830at2759; -.
DR PhylomeDB; Q8IVL1; -.
DR TreeFam; TF329881; -.
DR PathwayCommons; Q8IVL1; -.
DR SignaLink; Q8IVL1; -.
DR SIGNOR; Q8IVL1; -.
DR BioGRID-ORCS; 89797; 11 hits in 1078 CRISPR screens.
DR ChiTaRS; NAV2; human.
DR EvolutionaryTrace; Q8IVL1; -.
DR GeneWiki; NAV2; -.
DR GenomeRNAi; 89797; -.
DR Pharos; Q8IVL1; Tbio.
DR PRO; PR:Q8IVL1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IVL1; protein.
DR Bgee; ENSG00000166833; Expressed in blood vessel layer and 199 other tissues.
DR ExpressionAtlas; Q8IVL1; baseline and differential.
DR Genevisible; Q8IVL1; HS.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IDA:FlyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0021563; P:glossopharyngeal nerve development; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR GO; GO:0003025; P:regulation of systemic arterial blood pressure by baroreceptor feedback; IEA:Ensembl.
DR GO; GO:0007608; P:sensory perception of smell; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0021564; P:vagus nerve development; IEA:Ensembl.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784; PTHR12784; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Coiled coil; Helicase;
KW Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..2488
FT /note="Neuron navigator 2"
FT /id="PRO_0000267198"
FT DOMAIN 85..192
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 194..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1591..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1790..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1951..1985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2423..2488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 498..531
FT /evidence="ECO:0000255"
FT COILED 743..771
FT /evidence="ECO:0000255"
FT COILED 1686..1773
FT /evidence="ECO:0000255"
FT COILED 1897..1964
FT /evidence="ECO:0000255"
FT COMPBIAS 214..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1591..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1819..1834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1958..1985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2455..2470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 2157..2164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT MOD_RES 1480
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1484
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1488
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1977
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16964243,
FT ECO:0007744|PubMed:18669648"
FT VAR_SEQ 1..1896
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021924"
FT VAR_SEQ 1..1578
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_021925"
FT VAR_SEQ 1..937
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021926"
FT VAR_SEQ 1..89
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQ -> MESVSESSQQQKRKPVIH
FT GLEDQKR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12214280"
FT /id="VSP_021927"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MSVMLWRWEQNNTTMKL
FT (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021928"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MESVSESSQQQKRKPVIHG
FT LEDQKR (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021929"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MQECDSKFFLPSGSNSGFT
FT LLSNQ (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021930"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MAIDLYCGLACLWGIHEPR
FT (in isoform 13)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021931"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MLWPRNLT (in
FT isoform 8)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021932"
FT VAR_SEQ 1..88
FT /note="MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTY
FT PSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDT -> MAGTSAASSWGGGK (in
FT isoform 9)"
FT /evidence="ECO:0000303|PubMed:15158073"
FT /id="VSP_021933"
FT VAR_SEQ 256..278
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:10718198,
FT ECO:0000303|PubMed:11904404, ECO:0000303|PubMed:12214280"
FT /id="VSP_021934"
FT VAR_SEQ 938..945
FT /note="SLGLGDAD -> MLWPRNLT (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021935"
FT VAR_SEQ 1480..1501
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021936"
FT VAR_SEQ 1634..1666
FT /note="Missing (in isoform 2, isoform 3, isoform 4, isoform
FT 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:10718198,
FT ECO:0000303|PubMed:11904404, ECO:0000303|PubMed:12214280,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_021937"
FT VAR_SEQ 1832..1834
FT /note="Missing (in isoform 3, isoform 4, isoform 5 and
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:11904404,
FT ECO:0000303|PubMed:12214280, ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_021938"
FT VARIANT 109
FT /note="R -> K (in dbSNP:rs6483617)"
FT /evidence="ECO:0000269|PubMed:12214280,
FT ECO:0000269|PubMed:15158073"
FT /id="VAR_029640"
FT VARIANT 491
FT /note="Q -> H (in dbSNP:rs16937251)"
FT /id="VAR_029641"
FT VARIANT 1041
FT /note="E -> D (in dbSNP:rs3802799)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_029642"
FT VARIANT 1077
FT /note="P -> A (in dbSNP:rs3802800)"
FT /evidence="ECO:0000269|PubMed:10718198,
FT ECO:0000269|PubMed:11904404, ECO:0000269|PubMed:12214280,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15158073,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_029643"
FT VARIANT 2374
FT /note="V -> I (in dbSNP:rs35891966)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_032252"
FT CONFLICT 100
FT /note="A -> T (in Ref. 2; BAC00854 and 3; CAD32471)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="S -> P (in Ref. 1; AAL96479/AAL96480 and 4;
FT BAA92657)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="P -> S (in Ref. 3; CAD32471)"
FT /evidence="ECO:0000305"
FT CONFLICT 1046
FT /note="T -> M (in Ref. 7; BAB85038)"
FT /evidence="ECO:0000305"
FT CONFLICT 1173
FT /note="G -> D (in Ref. 7; BAB85038)"
FT /evidence="ECO:0000305"
FT CONFLICT 1845
FT /note="Missing (in Ref. 8; AAH16054)"
FT /evidence="ECO:0000305"
FT CONFLICT 1939
FT /note="M -> V (in Ref. 7; BAB85038)"
FT /evidence="ECO:0000305"
FT CONFLICT 2012
FT /note="E -> G (in Ref. 7; BAA91965)"
FT /evidence="ECO:0000305"
FT CONFLICT 2053
FT /note="V -> A (in Ref. 7; BAA91723)"
FT /evidence="ECO:0000305"
FT CONFLICT 2075
FT /note="L -> V (in Ref. 7; BAB85038)"
FT /evidence="ECO:0000305"
FT CONFLICT 2296
FT /note="K -> E (in Ref. 7; BAA91965)"
FT /evidence="ECO:0000305"
FT CONFLICT 2299
FT /note="E -> K (in Ref. 7; BAB85038)"
FT /evidence="ECO:0000305"
FT CONFLICT 2395
FT /note="M -> V (in Ref. 7; BAA91723)"
FT /evidence="ECO:0000305"
FT HELIX 86..101
FT /evidence="ECO:0007829|PDB:2YRN"
FT HELIX 111..114
FT /evidence="ECO:0007829|PDB:2YRN"
FT STRAND 115..118
FT /evidence="ECO:0007829|PDB:2YRN"
FT HELIX 119..128
FT /evidence="ECO:0007829|PDB:2YRN"
FT HELIX 145..159
FT /evidence="ECO:0007829|PDB:2YRN"
FT HELIX 169..174
FT /evidence="ECO:0007829|PDB:2YRN"
FT HELIX 177..191
FT /evidence="ECO:0007829|PDB:2YRN"
SQ SEQUENCE 2488 AA; 268167 MW; 0AEDD1C1469A11A8 CRC64;
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS
QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL
LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI
LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH
QPAPHQQSKA QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS
TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN
QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS
SPKIALKGIA QRTFSRALTN KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK
EEPKEDPSGA AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT
VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS
VEPSHFTKTG QPALEELTGE DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT
FDTNVTTEMS GRSILSLTGR PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE
SGRYVYSAPL RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT
IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD
SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP
AGALKTPGTG KTDDAKVSEK GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA
NSFGFKKQSG SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA
LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP
TLRRLFGGKP TKQVPIATAE NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS
KNVDLNQSPL ASSPSSAHSA PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS
LSSGGVPSHN SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP
SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT
MSRSGSFRDG FEEESWEKSS VDNFVSRLHS SLHFSLPLFH HARYELVHGS SLSLVSSTSS
VYSTPEEKCQ SEIRKLRREL DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM
TAEQKDSELN ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS
DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK SASSHSDIEE
MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE AETVMQLRNE LRDKEMKLTD
IRLEALSSAH QLDQLREAMN RMQSEIEKLK AENDRLKSES QGSGCSRAPS QVSISASPRQ
SMGLSQHSLN LTESTSLDML LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI
GCIGVSGKTK WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE
LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH RRIILSGPSG
TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL RQYLSNLADQ CNSENNAVDM
PLVIILDNLH HVSSLGEIFN GLLNCKYHKC PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN
HTEPVKGFLG RFLRRKLMET EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG
PRLFLSCPID VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW
AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM LMRLQEAANY
SSPQSYDSDS NSNSHHDDIL DSSLESTL
