NAV3_DANRE
ID NAV3_DANRE Reviewed; 2269 AA.
AC Q5TZ18;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Neuron navigator 3;
GN Name=nav3; ORFNames=si:dkeyp-60g2.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: May be involved in neuron regeneration. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
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DR EMBL; BX537169; CAH69140.1; -; Genomic_DNA.
DR EMBL; BX511172; CAH69140.1; JOINED; Genomic_DNA.
DR EMBL; BX511172; CAI20640.1; -; Genomic_DNA.
DR EMBL; BX537169; CAI20640.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001038608.1; NM_001045143.2.
DR AlphaFoldDB; Q5TZ18; -.
DR SMR; Q5TZ18; -.
DR STRING; 7955.ENSDARP00000098329; -.
DR PaxDb; Q5TZ18; -.
DR PRIDE; Q5TZ18; -.
DR Ensembl; ENSDART00000005847; ENSDARP00000021413; ENSDARG00000005476.
DR GeneID; 567779; -.
DR KEGG; dre:567779; -.
DR CTD; 89795; -.
DR ZFIN; ZDB-GENE-021205-1; nav3.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR GeneTree; ENSGT00940000158014; -.
DR HOGENOM; CLU_001002_1_1_1; -.
DR InParanoid; Q5TZ18; -.
DR OrthoDB; 21830at2759; -.
DR PhylomeDB; Q5TZ18; -.
DR TreeFam; TF329881; -.
DR PRO; PR:Q5TZ18; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000005476; Expressed in cranial skeletal system and 42 other tissues.
DR ExpressionAtlas; Q5TZ18; baseline.
DR GO; GO:0030175; C:filopodium; IDA:ZFIN.
DR GO; GO:0005794; C:Golgi apparatus; IDA:ZFIN.
DR GO; GO:0030027; C:lamellipodium; IDA:ZFIN.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IDA:ZFIN.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0072576; P:liver morphogenesis; IMP:ZFIN.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IMP:ZFIN.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784; PTHR12784; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Nucleus; Reference proteome.
FT CHAIN 1..2269
FT /note="Neuron navigator 3"
FT /id="PRO_0000286978"
FT DOMAIN 55..162
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 186..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1461..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1756..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2207..2269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..672
FT /evidence="ECO:0000255"
FT COILED 1499..1586
FT /evidence="ECO:0000255"
FT COILED 1697..1765
FT /evidence="ECO:0000255"
FT COMPBIAS 186..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1604..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2269 AA; 242554 MW; 4DAFA6DED2408692 CRC64;
MAHGLAPRSS ELRVTESPML SCQLSFKTEI HDRRTNLVPA PAATLARSSR EAEESKICKI
YTDWANHYLA KSGCPRLIKD LTQDIPDGVL LAEIIQIIAN EKIEDINSCP KSHSQMIENV
ECCLSFLGAR GVSVQGLSAE EVCNGNLKSI LGLFFILSRY KQQQQHQQQY LQSLVELQQH
VTHQTTGAAQ LSQHKTQDMQ SSLTARYTSP PGHSGIAAPQ KKNTRLPGPS RVPAAGSGSN
SSKGSSNLNR RSQSFNSIDK SKPLQYASGN DRGSMNGSGS VPSSTSGQQL ASAIPSPTAG
KTWRSKSMNM KHSATSSMLA TKPPSPTSSP TPPSSSDRLR PPITDASKSA PGNQRSMLEK
FRILNPRATS RTSPSVAEMA LQEEDDLSEF GDEGTFSPTP PCGISKQQGK PSASAFAPPS
KSNNCKNHNN KSLPQPKDKE DKNKTKNKAS TPPKEEPVIV ETSKKGSKIA SLIPKGSKTS
AASVKKESAI PASSSIPKPG LKAPTATSKP AGTQSCVPAT TGGEKTKLNK GSQSIYMQRS
LGGLENRKTS MVLSTSTSAL SASTTSGLGG GCALGGNGAV QLPQQQQHNH PNTATVAPFM
YRTYSENDCT TVVPPEPCLS PTKELVYGKT AKQCLEEISG EDPETRRMRT VKNIADLRQN
LEETMSSLRG TQITHSTLET TFDTTVTTEV NGRGLPALSS RSSPMSWRLG QGSSPRLQAG
DAPSYTPPRS SAGSTTVRYG EPSRLLYTAP LRRAAASGAR GAEPGEKGGI SEVGPEVDVT
GYGSDGDILA KNVHADDISG YHTDGGIYSR NVDLYSRNVG RPAEMTPARE VVQKGVKEMQ
GEDSWDDSSS VSSGLSDTLD NISTDDLNPA PYSGISSRKS KAAQSNKETH RHIEQDASSW
AGAEDLKKVD EEMEPGMDPS CKWKTSSPSS SCQGEDISQK TGLPMSQTGS WRRGMSAQVG
ITPPRTKGTS TSLKTPGKTD DAKASEKGKG SPKSPSIQRS PSDAGKSSGD EGKKPPSGIA
RPPTTSSFGY KKIPGPAGAL ITASGATLTS GSATLGKVPK SACIGKSTGI SNGRKTSLDG
AQHQDDAVLL GCGGSEVPLQ YRSLPRPAKS SSGGSSVVSR SGHRSSSSSI DSNVSGKSAG
GSGVAVGTPT STKRRDTGKV GSGRSSPVTI NQTDKEKVAG SDQEGTGLPT SPKSSPTSTQ
SGLRQPGSKY PDIASPTFRR LFGSKASSKP SSPGTPDSGK CPSALGSPHG TLARQASLDS
PSSGTGSLGS MGGQSGGSSP LYGKTPDLGT DSPASSPASG LSLPSNARPW PPNLSSSSAG
SKDTLSCHSM TSLHTSSESI DLPLPHHHGP KVTRTGSVKS TLSEGMPLDR NTLPKKGLRQ
TSHEEGKEWL RSHSTGGLQD TGSPLSPPGT TCANAGKYHY SNLLSPTSMS QYNIPSTSMS
RSNSIPAQDS FELYGEGHPL GGSATSLEER PRGMSRSGSF RDSTDEVHGS SLSLVSSTSS
LYSAQIRKLR RELDASQEKV ATLTSQLAAN AHLVAAFEKS LANMTCRLQS LTMTAEQKES
ELAELRETIE ALKTQNTDAQ TAIQVALNGP DHVHRDLRIR RQHSSESMSS INSAASHSSL
GSAKDAEDKK KKKKSWLRSS FKQAFSKKKT NKPQSSHDEI EEMTDSSLPS SPKLLHISRQ
ASSPQPLLSS PSTTELCECT EAEAEIILQL KNELREKELK LTDIRLEALS SAHHLDQIRE
AMNRMQNEIE LLKAENDRLK SSGNTTPAAT PAKTARPPSE TSSTSSSSSR QSLGLSLNNL
NITDTIMSDI LLDDGYEGNL RKEGRSVRIV VTINSDSNKT KAMQKKQYLI GSIGVSGKTK
WDVLDGVIRR LFKEYVFRVD PLTSLGMNSD SIVCYRMGDV VRSHASEVPE LLPCGYLVGD
NNVITVTLKG VKEGSIDDLV FDTLIPKPII QRYLNLLMEH RRIILSGPSG TGKSYLATKL
AYFILSKTGR EVTDTNLATF NVDQKSSKDL RQYLSSLAEQ CNTEECEIEL PTVVILDNLH
HIGSLSDIFN GFLNCKYHKC PYVIGTMNQG VSSSPNLELH HNFRWVLCAN HTEPVKGFLG
RFLRRKLIET EIDKNMRSND LIKIIDWIPK IWQHLNSFLE AHSSSDVTIG PRLFLSCPMD
ADGSRVWFTD LWNYSLVPYL LEAVREGLQH EGQSLLQLRP EDVGYDGYSS SKDGAASKQV
SQSDTEGDPL MNMLMRLQEA ANYSSAQSCD SDSASHHEDL LDSSLESAL
