NAV3_HUMAN
ID NAV3_HUMAN Reviewed; 2385 AA.
AC Q8IVL0; Q8NFW7; Q9Y2E7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Neuron navigator 3;
DE AltName: Full=Pore membrane and/or filament-interacting-like protein 1;
DE AltName: Full=Steerin-3;
DE AltName: Full=Unc-53 homolog 3;
DE Short=unc53H3;
GN Name=NAV3; Synonyms=KIAA0938, POMFIL1, STEERIN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP ALA-45.
RX PubMed=15158073; DOI=10.1016/j.devbrainres.2004.03.004;
RA Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P.,
RA Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E.;
RT "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-
RT 53.";
RL Brain Res. Dev. Brain Res. 150:89-101(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 82-2385 (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=12079279; DOI=10.1006/geno.2002.6799;
RA Maes T., Barcelo A., Buesa C.;
RT "Neuron navigator: a human gene family with homology to unc-53, a cell
RT guidance gene from Caenorhabditis elegans.";
RL Genomics 80:21-30(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 930-2385 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [5]
RP IDENTIFICATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12062803; DOI=10.1016/s0378-1119(02)00567-x;
RA Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O.,
RA Christiansen H., Poustka A.;
RT "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is
RT predominantly expressed in the nervous system and encodes different protein
RT isoforms.";
RL Gene 290:73-94(2002).
RN [6]
RP CHROMOSOMAL TRANSLOCATION, VARIANT LYS-2200, TISSUE SPECIFICITY, AND
RP FUNCTION.
RX PubMed=16166283; DOI=10.1158/0008-5472.can-04-0366;
RA Karenko L., Hahtola S., Paeivinen S., Karhu R., Syrjae S., Kaehkoenen M.,
RA Nedoszytko B., Kytoelae S., Zhou Y., Blazevic V., Pesonen M., Nevala H.,
RA Nupponen N., Sihto H., Krebs I., Poustka A., Roszkiewicz J., Saksela K.,
RA Peterson P., Visakorpi T., Ranki A.;
RT "Primary cutaneous T-cell lymphomas show a deletion or translocation
RT affecting NAV3, the human UNC-53 homologue.";
RL Cancer Res. 65:8101-8110(2005).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1459 AND SER-1463, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: May regulate IL2 production by T-cells. May be involved in
CC neuron regeneration. {ECO:0000269|PubMed:16166283}.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IVL0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IVL0-2; Sequence=VSP_025269;
CC Name=3;
CC IsoId=Q8IVL0-3; Sequence=VSP_025268, VSP_025269;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain. Expressed at low levels
CC in heart and placenta. Present in activated T-cells but not in resting
CC T-cells (at protein level). Down-regulated in primary neuroblastoma.
CC {ECO:0000269|PubMed:12062803, ECO:0000269|PubMed:12079279,
CC ECO:0000269|PubMed:15158073, ECO:0000269|PubMed:16166283}.
CC -!- DEVELOPMENTAL STAGE: Expressed in fetal brain.
CC {ECO:0000269|PubMed:12062803}.
CC -!- DISEASE: Note=A chromosomal aberration disrupting NAV3 has been found
CC in patients with Sezary syndrome (PubMed:16166283). Translocation
CC t(12;18)(q21;q21.2) (PubMed:16166283). {ECO:0000269|PubMed:16166283}.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ488201; CAD32554.1; -; mRNA.
DR EMBL; AC073571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC078822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF397731; AAM73757.1; -; mRNA.
DR EMBL; AB023155; BAA76782.2; -; mRNA.
DR CCDS; CCDS41815.1; -. [Q8IVL0-2]
DR CCDS; CCDS66432.1; -. [Q8IVL0-1]
DR RefSeq; NP_001019554.1; NM_001024383.1. [Q8IVL0-1]
DR RefSeq; NP_055718.4; NM_014903.5. [Q8IVL0-2]
DR RefSeq; XP_011537246.1; XM_011538944.2. [Q8IVL0-3]
DR AlphaFoldDB; Q8IVL0; -.
DR SMR; Q8IVL0; -.
DR BioGRID; 124604; 20.
DR IntAct; Q8IVL0; 4.
DR MINT; Q8IVL0; -.
DR STRING; 9606.ENSP00000381007; -.
DR GlyConnect; 2059; 1 N-Linked glycan (1 site).
DR GlyGen; Q8IVL0; 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (2 sites).
DR iPTMnet; Q8IVL0; -.
DR PhosphoSitePlus; Q8IVL0; -.
DR SwissPalm; Q8IVL0; -.
DR BioMuta; NAV3; -.
DR DMDM; 313104213; -.
DR EPD; Q8IVL0; -.
DR jPOST; Q8IVL0; -.
DR MassIVE; Q8IVL0; -.
DR MaxQB; Q8IVL0; -.
DR PaxDb; Q8IVL0; -.
DR PeptideAtlas; Q8IVL0; -.
DR PRIDE; Q8IVL0; -.
DR ProteomicsDB; 70721; -. [Q8IVL0-1]
DR ProteomicsDB; 70722; -. [Q8IVL0-2]
DR ProteomicsDB; 70723; -. [Q8IVL0-3]
DR Antibodypedia; 29726; 77 antibodies from 19 providers.
DR DNASU; 89795; -.
DR Ensembl; ENST00000397909.7; ENSP00000381007.2; ENSG00000067798.16. [Q8IVL0-1]
DR Ensembl; ENST00000536525.6; ENSP00000446132.2; ENSG00000067798.16. [Q8IVL0-2]
DR GeneID; 89795; -.
DR KEGG; hsa:89795; -.
DR MANE-Select; ENST00000397909.7; ENSP00000381007.2; NM_001024383.2; NP_001019554.1.
DR UCSC; uc001syo.5; human. [Q8IVL0-1]
DR CTD; 89795; -.
DR DisGeNET; 89795; -.
DR GeneCards; NAV3; -.
DR HGNC; HGNC:15998; NAV3.
DR HPA; ENSG00000067798; Tissue enhanced (brain, ovary).
DR MIM; 611629; gene.
DR neXtProt; NX_Q8IVL0; -.
DR OpenTargets; ENSG00000067798; -.
DR PharmGKB; PA31453; -.
DR VEuPathDB; HostDB:ENSG00000067798; -.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR GeneTree; ENSGT00940000158014; -.
DR HOGENOM; CLU_001002_1_0_1; -.
DR InParanoid; Q8IVL0; -.
DR OMA; SSLYSTX; -.
DR OrthoDB; 21830at2759; -.
DR PhylomeDB; Q8IVL0; -.
DR TreeFam; TF329881; -.
DR PathwayCommons; Q8IVL0; -.
DR SignaLink; Q8IVL0; -.
DR BioGRID-ORCS; 89795; 4 hits in 1069 CRISPR screens.
DR ChiTaRS; NAV3; human.
DR GenomeRNAi; 89795; -.
DR Pharos; Q8IVL0; Tbio.
DR PRO; PR:Q8IVL0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8IVL0; protein.
DR Bgee; ENSG00000067798; Expressed in middle temporal gyrus and 164 other tissues.
DR ExpressionAtlas; Q8IVL0; baseline and differential.
DR Genevisible; Q8IVL0; HS.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IMP:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IMP:UniProtKB.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784; PTHR12784; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; Coiled coil; Membrane;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..2385
FT /note="Neuron navigator 3"
FT /id="PRO_0000286976"
FT DOMAIN 77..184
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 17..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..1881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2360..2385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 679..707
FT /evidence="ECO:0000255"
FT COILED 1562..1653
FT /evidence="ECO:0000255"
FT COILED 1794..1861
FT /evidence="ECO:0000255"
FT COMPBIAS 203..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1860..1881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1459
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 1463
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT VAR_SEQ 1250..1426
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10231032"
FT /id="VSP_025268"
FT VAR_SEQ 1767..1788
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:10231032,
FT ECO:0000303|PubMed:12079279"
FT /id="VSP_025269"
FT VARIANT 45
FT /note="T -> A (in dbSNP:rs10735309)"
FT /evidence="ECO:0000269|PubMed:15158073"
FT /id="VAR_032249"
FT VARIANT 210
FT /note="S -> W (in dbSNP:rs34195711)"
FT /id="VAR_032250"
FT VARIANT 2200
FT /note="E -> K (in a patient with Sezary syndrome)"
FT /evidence="ECO:0000269|PubMed:16166283"
FT /id="VAR_032251"
FT CONFLICT 677
FT /note="D -> G (in Ref. 1; CAD32554)"
FT /evidence="ECO:0000305"
FT CONFLICT 924
FT /note="L -> V (in Ref. 3; AAM73757)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2385 AA; 255648 MW; 23706AF34D2018FA CRC64;
MPVLGVASKL RQPAVGSKPV HTALPIPNLG TTGSQHCSSR PLELTETESS MLSCQLALKS
TCEFGEKKPL QGKAKEKEDS KIYTDWANHY LAKSGHKRLI KDLQQDIADG VLLAEIIQII
ANEKVEDING CPRSQSQMIE NVDVCLSFLA ARGVNVQGLS AEEIRNGNLK AILGLFFSLS
RYKQQQHHQQ QYYQSLVELQ QRVTHASPPS EASQAKTQQD MQSSLAARYA TQSNHSGIAT
SQKKPTRLPG PSRVPAAGSS SKVQGASNLN RRSQSFNSID KNKPPNYANG NEKDSSKGPQ
SSSGVNGNVQ PPSTAGQPPA SAIPSPSASK PWRSKSMNVK HSATSTMLTV KQSSTATSPT
PSSDRLKPPV SEGVKTAPSG QKSMLEKFKL VNARTALRPP QPPSSGPSDG GKDDDAFSES
GEMEGFNSGL NSGGSTNSSP KVSPKLAPPK AGSKNLSNKK SLLQPKEKEE KNRDKNKVCT
EKPVKEEKDQ VTEMAPKKTS KIASLIPKGS KTTAAKKESL IPSSSGIPKP GSKVPTVKQT
ISPGSTASKE SEKFRTTKGS PSQSLSKPIT MEKASASSCP APLEGREAGQ ASPSGSCTMT
VAQSSGQSTG NGAVQLPQQQ QHSHPNTATV APFIYRAHSE NEGTALPSAD SCTSPTKMDL
SYSKTAKQCL EEISGEDPET RRMRTVKNIA DLRQNLEETM SSLRGTQISH STLETTFDST
VTTEVNGRTI PNLTSRPTPM TWRLGQACPR LQAGDAPSLG AGYPRSGTSR FIHTDPSRFM
YTTPLRRAAV SRLGNMSQID MSEKASSDLD MSSEVDVGGY MSDGDILGKS LRTDDINSGY
MTDGGLNLYT RSLNRIPDTA TSRDIIQRGV HDVTVDADSW DDSSSVSSGL SDTLDNISTD
DLNTTSSVSS YSNITVPSRK NTQLRTDSEK RSTTDETWDS PEELKKPEED FDSHGDAGGK
WKTVSSGLPE DPEKAGQKAS LSVSQTGSWR RGMSAQGGAP SRQKAGTSAL KTPGKTDDAK
ASEKGKAPLK GSSLQRSPSD AGKSSGDEGK KPPSGIGRST ATSSFGFKKP SGVGSSAMIT
SSGATITSGS ATLGKIPKSA AIGGKSNAGR KTSLDGSQNQ DDVVLHVSSK TTLQYRSLPR
PSKSSTSGIP GRGGHRSSTS SIDSNVSSKS AGATTSKLRE PTKIGSGRSS PVTVNQTDKE
KEKVAVSDSE SVSLSGSPKS SPTSASACGA QGLRQPGSKY PDIASPTFRR LFGAKAGGKS
ASAPNTEGVK SSSVMPSPST TLARQGSLES PSSGTGSMGS AGGLSGSSSP LFNKPSDLTT
DVISLSHSLA SSPASVHSFT SGGLVWAANM SSSSAGSKDT PSYQSMTSLH TSSESIDLPL
SHHGSLSGLT TGTHEVQSLL MRTGSVRSTL SESMQLDRNT LPKKGLRYTP SSRQANQEEG
KEWLRSHSTG GLQDTGNQSP LVSPSAMSSS AAGKYHFSNL VSPTNLSQFN LPGPSMMRSN
SIPAQDSSFD LYDDSQLCGS ATSLEERPRA ISHSGSFRDS MEEVHGSSLS LVSSTSSLYS
TAEEKAHSEQ IHKLRRELVA SQEKVATLTS QLSANAHLVA AFEKSLGNMT GRLQSLTMTA
EQKESELIEL RETIEMLKAQ NSAAQAAIQG ALNGPDHPPK DLRIRRQHSS ESVSSINSAT
SHSSIGSGND ADSKKKKKKN WVNSRGSELR SSFKQAFGKK KSTKPPSSHS DIEELTDSSL
PASPKLPHNA GDCGSASMKP SQSASASPLV WPPKKRQNGP VIYKHRSRIC ECTEAEAEII
LQLKSELREK ELKLTDIRLE ALSSAHHLDQ IREAMNRMQN EIEILKAEND RLKAETGNTA
KPTRPPSESS SSTSSSSSRQ SLGLSLNNLN ITEAVSSDIL LDDAGDATGH KDGRSVKIIV
SISKGYGRAK DQKSQAYLIG SIGVSGKTKW DVLDGVIRRL FKEYVFRIDT STSLGLSSDC
IASYCIGDLI RSHNLEVPEL LPCGYLVGDN NIITVNLKGV EENSLDSFVF DTLIPKPITQ
RYFNLLMEHH RIILSGPSGT GKTYLANKLA EYVITKSGRK KTEDAIATFN VDHKSSKELQ
QYLANLAEQC SADNNGVELP VVIILDNLHH VGSLSDIFNG FLNCKYNKCP YIIGTMNQGV
SSSPNLELHH NFRWVLCANH TEPVKGFLGR YLRRKLIEIE IERNIRNNDL VKIIDWIPKT
WHHLNSFLET HSSSDVTIGP RLFLPCPMDV EGSRVWFMDL WNYSLVPYIL EAVREGLQMY
GKRTPWEDPS KWVLDTYPWS SATLPQESPA LLQLRPEDVG YESCTSTKEA TTSKHIPQTD
TEGDPLMNML MKLQEAANYS STQSCDSEST SHHEDILDSS LESTL
