NAZO_DROME
ID NAZO_DROME Reviewed; 140 AA.
AC Q9VHT9;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Protein Nazo {ECO:0000305};
GN Name=Nazo {ECO:0000312|FlyBase:FBgn0037562};
GN ORFNames=CG11671 {ECO:0000312|FlyBase:FBgn0037562};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Wan K., Booth B., Spirohn K., Hao T., Hu Y., Calderwood M., Hill D.,
RA Mohr S., Vidal M., Celniker S., Perrimon N.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=30119996; DOI=10.1016/j.immuni.2018.07.013;
RA Goto A., Okado K., Martins N., Cai H., Barbier V., Lamiable O., Troxler L.,
RA Santiago E., Kuhn L., Paik D., Silverman N., Holleufer A., Hartmann R.,
RA Liu J., Peng T., Hoffmann J.A., Meignin C., Daeffler L., Imler J.L.;
RT "The kinase IKKbeta regulates a STING- and NF-kappaB-dependent antiviral
RT response pathway in Drosophila.";
RL Immunity 49:225-234(2018).
CC -!- FUNCTION: Antiviral effector protein expressed downstream of Sting and
CC Rel (Relish) signaling in response to viral infection.
CC {ECO:0000269|PubMed:30119996}.
CC -!- INDUCTION: Expression is directly activated by Rel (Relish).
CC {ECO:0000269|PubMed:30119996}.
CC -!- MISCELLANEOUS: Was named Nazo, after the Japanese name 'enigma'.
CC {ECO:0000305|PubMed:30119996}.
CC -!- SIMILARITY: Belongs to the C19orf12 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54210.2; -; Genomic_DNA.
DR EMBL; AY118861; AAM50721.1; -; mRNA.
DR EMBL; KX531291; ANY27101.1; -; mRNA.
DR RefSeq; NP_649778.1; NM_141521.2.
DR AlphaFoldDB; Q9VHT9; -.
DR IntAct; Q9VHT9; 9.
DR STRING; 7227.FBpp0081319; -.
DR PaxDb; Q9VHT9; -.
DR DNASU; 40976; -.
DR EnsemblMetazoa; FBtr0081829; FBpp0081319; FBgn0037562.
DR GeneID; 40976; -.
DR KEGG; dme:Dmel_CG11671; -.
DR UCSC; CG11671-RA; d. melanogaster.
DR CTD; 40976; -.
DR FlyBase; FBgn0037562; Nazo.
DR VEuPathDB; VectorBase:FBgn0037562; -.
DR eggNOG; ENOG502RZQC; Eukaryota.
DR HOGENOM; CLU_138025_1_0_1; -.
DR InParanoid; Q9VHT9; -.
DR OMA; IQTTVKG; -.
DR OrthoDB; 1474873at2759; -.
DR PhylomeDB; Q9VHT9; -.
DR BioGRID-ORCS; 40976; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40976; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037562; Expressed in midgut and 10 other tissues.
DR GO; GO:0051607; P:defense response to virus; IMP:FlyBase.
DR GO; GO:0050905; P:neuromuscular process; IGI:FlyBase.
DR InterPro; IPR033369; C19orf12.
DR PANTHER; PTHR31493; PTHR31493; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Reference proteome.
FT CHAIN 1..140
FT /note="Protein Nazo"
FT /id="PRO_0000454451"
SQ SEQUENCE 140 AA; 14919 MW; 6D41AFC20ABFD273 CRC64;
MDSAISEIIN ALAILADDKN IQLTIKEAGK GAAICAGAAL IGGLLLGPRG LALGGAIGGL
TAYGLTEGNF KSLSEVILND LTESQRRELE QHVIRAISEV RNVRVRDVAR LILNNRHVQE
VALEAVKSYI TDRMGMTIVD
