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NB5R4_XENTR
ID   NB5R4_XENTR             Reviewed;         523 AA.
AC   Q28CZ9;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Cytochrome b5 reductase 4;
DE            EC=1.6.2.2;
DE   AltName: Full=Flavohemoprotein b5/b5R;
DE            Short=b5+b5R;
DE   AltName: Full=cb5/cb5R;
GN   Name=cyb5r4; ORFNames=TGas070l21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic
CC       reticulum stress response pathway. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] +
CC         H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA-
CC         COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum. Note=Soluble protein.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome
CC       reductase family. {ECO:0000305}.
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DR   EMBL; CR855785; CAJ83762.1; -; mRNA.
DR   RefSeq; NP_001016756.1; NM_001016756.2.
DR   AlphaFoldDB; Q28CZ9; -.
DR   SMR; Q28CZ9; -.
DR   STRING; 8364.ENSXETP00000048892; -.
DR   PaxDb; Q28CZ9; -.
DR   GeneID; 549510; -.
DR   KEGG; xtr:549510; -.
DR   CTD; 51167; -.
DR   Xenbase; XB-GENE-984179; cyb5r4.
DR   eggNOG; KOG0534; Eukaryota.
DR   eggNOG; KOG0536; Eukaryota.
DR   HOGENOM; CLU_003827_0_2_1; -.
DR   InParanoid; Q28CZ9; -.
DR   OrthoDB; 1311668at2759; -.
DR   PhylomeDB; Q28CZ9; -.
DR   Reactome; R-XTR-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; IBA:GO_Central.
DR   GO; GO:0006801; P:superoxide metabolic process; IBA:GO_Central.
DR   CDD; cd06490; p23_NCB5OR; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 3.10.120.10; -; 1.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR001834; CBR-like.
DR   InterPro; IPR008333; Cbr1-like_FAD-bd_dom.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR018506; Cyt_B5_heme-BS.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR037908; p23_NCB5OR.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR19370; PTHR19370; 1.
DR   Pfam; PF04969; CS; 1.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   Pfam; PF00970; FAD_binding_6; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00363; CYTOCHROMEB5.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; FAD; Flavoprotein; Heme; Iron; Metal-binding; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..523
FT                   /note="Cytochrome b5 reductase 4"
FT                   /id="PRO_0000287560"
FT   DOMAIN          54..130
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   DOMAIN          167..258
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   DOMAIN          275..387
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
FT   BINDING         89
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         112
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
FT   BINDING         367..382
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         394..426
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   523 AA;  59216 MW;  BF4CEECC9085903C CRC64;
     MLNVPSQSFP APSSQQRVAA IGRSKVPLKP GRSLMDWIRL TKSGKDLTGL KGRLIDVTEE
     ELAQHNKKED CWICIRGMVY NITPYMEYHP GGEEELMKAA GRDGTDLFDQ VHRWVNYESM
     LKECLIGRMA IKHVSISKEV TSVENKMNKH LNGSVASSKM SRTSSKESHP WYDWFQTESL
     VTVAVYTKMK NVCSELVIVD HLENVLRGEI IIGDYSYLLH SELSHPVQKD IEVKVSATAG
     KIEIKMKKKE PVSWKSLGQP MDGHNSFLKH SQRGLYYRKC RLASKTDINY NTKLFCVQLP
     QGCHLQVPVG HHIYLKMNIS GVDIVKPYTP VASCLLPDAQ YSTFCNKQCL YLMIKIYPNG
     SITPHLENLT VGDYISISNP QGTFSSFQIE NVMDVFLVAA GTGITPMIRL LQHVLTCVSS
     LRKAKLIFFN KKEEDILWKE QVEELSLADK RFEAQLILSE PSVKWTGYRG QISYSLLNES
     ILRTEEGSKI LICICGPNAF VDQGISFLQD LGFSKEEVFA FRE
 
 
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