NBDY_PONAB
ID NBDY_PONAB Reviewed; 68 AA.
AC Q5RDV1;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Negative regulator of P-body association {ECO:0000250|UniProtKB:A0A0U1RR68};
DE AltName: Full=P-body dissociating protein {ECO:0000250|UniProtKB:A0A0U1RR68};
DE AltName: Full=Protein NoBody {ECO:0000250|UniProtKB:A0A0U1RR68};
GN Name=NBDY {ECO:0000250|UniProtKB:A0A0U1RR68};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes dispersal of P-body components and is likely to play
CC a role in the mRNA decapping process.
CC {ECO:0000250|UniProtKB:A0A0U1RR68}.
CC -!- SUBUNIT: Interacts with mRNA decapping proteins DCP1A, DCP2 and EDC4.
CC {ECO:0000250|UniProtKB:A0A0U1RR68}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000250|UniProtKB:A0A0U1RR68}. Note=Localizes to P-bodies at low
CC concentrations without dissociating them.
CC {ECO:0000250|UniProtKB:A0A0U1RR68}.
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DR EMBL; CR857793; CAH90056.1; -; mRNA.
DR AlphaFoldDB; Q5RDV1; -.
DR Ensembl; ENSPPYT00000060833; ENSPPYP00000033482; ENSPPYG00000031732.
DR GeneTree; ENSGT00390000004891; -.
DR HOGENOM; CLU_2793310_0_0_1; -.
DR InParanoid; Q5RDV1; -.
DR OMA; NTRETRP; -.
DR TreeFam; TF353536; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0010607; P:negative regulation of cytoplasmic mRNA processing body assembly; ISS:UniProtKB.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; Reference proteome.
FT CHAIN 1..68
FT /note="Negative regulator of P-body association"
FT /id="PRO_0000342660"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 30
FT /note="Required for interaction with EDC4"
FT /evidence="ECO:0000250|UniProtKB:A0A0U1RR68"
FT SITE 34
FT /note="Required for interaction with EDC4"
FT /evidence="ECO:0000250|UniProtKB:A0A0U1RR68"
SQ SEQUENCE 68 AA; 7025 MW; FA372C7380B65853 CRC64;
MGDQPCASGR STLPPGNARE AKPPKKRCLL APRWDYPEGT PNGGSTTLPS APPPASAGLK
SHPPPPEK