ID   NBEA_CHICK              Reviewed;         793 AA.
AC   Q9DDD5;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Neurobeachin;
DE   Flags: Fragment;
GN   Name=NBEA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000312|EMBL:CAC18801.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000312|EMBL:CAC18801.1};
RX   PubMed=11102458; DOI=10.1523/jneurosci.20-23-08551.2000;
RA   Wang X., Herberg F.W., Laue M.M., Wullner C., Hu B., Petrasch-Parwez E.,
RA   Kilimann M.W.;
RT   "Neurobeachin: a protein kinase A-anchoring, beige/Chediak-Higashi protein
RT   homolog implicated in neuronal membrane traffic.";
RL   J. Neurosci. 20:8551-8565(2000).
CC   -!- FUNCTION: Binds to type II regulatory subunits of protein kinase A and
CC       anchors/targets them to the membrane. May anchor the kinase to
CC       cytoskeletal and/or organelle-associated proteins (By similarity).
CC       {ECO:0000250|UniProtKB:Q9EPN1}.
CC   -!- SUBUNIT: Interacts with RII subunit of PKA.
CC       {ECO:0000250|UniProtKB:Q9EPN1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Forebrain and cerebellum.
CC       {ECO:0000269|PubMed:11102458}.
CC   -!- SIMILARITY: Belongs to the WD repeat neurobeachin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y18277; CAC18801.1; -; mRNA.
DR   AlphaFoldDB; Q9DDD5; -.
DR   STRING; 9031.ENSGALP00000027504; -.
DR   VEuPathDB; HostDB:geneid_395195; -.
DR   eggNOG; KOG1787; Eukaryota.
DR   InParanoid; Q9DDD5; -.
DR   OrthoDB; 153369at2759; -.
DR   PhylomeDB; Q9DDD5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           <1..>793
FT                   /note="Neurobeachin"
FT                   /id="PRO_0000051091"
FT   REGION          68..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..713
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..793
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CAC18801.1"
FT   NON_TER         793
FT                   /evidence="ECO:0000312|EMBL:CAC18801.1"
SQ   SEQUENCE   793 AA;  87803 MW;  19F5AC6C49A7F2A2 CRC64;
     PKNSEEQKIT EMVYNIFRIL LYHAIKYEWG GWRVWVDTLS IAHSKVTYEA HKEYLAKMYE
     EYQRQEEENI KKGKKGNVST ISGLSSQTTG AKGGMEIREI EDLSQSQSPE SETDYPVSTD
     TRDLLMATKV SDDVLGSAER PGGGVHVEVH DLLVDIKAER VEATEVKLDD MDLSPETLVT
     GENGALVEVE SLLDNVYSAA VEKLQNSVHG SVGIIKKNEE KDGGPLITLA DEKDEPSTNS
     TSFLFDKIPS QEEKLLPDLS ISHISIPNVQ DTQMHLGVND DLGLLAHMTG GVDITSTSSI
     IEDKEFKIHT NSVGMSSIFE RELASLFKGL EYAEMTATTP ETEFFCSKTV PNVDAGSIIS
     VTERFVDGKE AGKEIRKIQT TTTTQAVQGR SVTQQDRDLR VDLGFRGMPM TEEQRRQFSP
     GPRTNMFRIP EFKWSPMHQR LLTDLLFALE TDVHVWRSHS TKSVMDFVNS NENIIFVHNT
     IHLISQMVDN IIIACGGILP LLSAATSPTG SKTELENIEV TQGMSAETAV TFLSRLMAMV
     DVLVFASSLN FSEIEAEKNM SSGGLMRQCL RLVCCVAVRN CLECRQRQRE RVNKTSLISS
     KAQDALQGVT ASAATKTPLE NVPGNLSPIK DPDRLLQDVD INRLRAVVFR DVDDSKQAQF
     LALAVVYFIS VLMVSKYRDI LEPQRETARS GSQAGRNIRQ EINSPTSTET PAVFPENIKD
     KETPTPVEDI QLESSIPHTD SGIGEEQMPN ILNGTDLETS TGPDAMSELL STLSSEVKKS
     QESLTESPSE ILK