NBL1_CHICK
ID NBL1_CHICK Reviewed; 177 AA.
AC Q90YC9; Q8QGI6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Neuroblastoma suppressor of tumorigenicity 1;
DE AltName: Full=Cysteine knot secreted protein DAN;
DE Short=cDAN;
DE Flags: Precursor;
GN Name=NBL1; Synonyms=DAN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11731250; DOI=10.1016/s0925-4773(01)00522-6;
RA Ogita J., Isogai E., Sudo H., Sakiyama S., Nakagawara A., Koseki H.;
RT "Expression of the Dan gene during chicken embryonic development.";
RL Mech. Dev. 109:363-365(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11984879; DOI=10.1002/dvdy.10079;
RA Gerlach-Bank L.M., Ellis A.D., Noonen B., Barald K.F.;
RT "Cloning and expression analysis of the chick DAN gene, an antagonist of
RT the BMP family of growth factors.";
RL Dev. Dyn. 224:109-115(2002).
CC -!- FUNCTION: May act as a tumor suppressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in head mesenchyme, somitic mesoderm and
CC notochord at stages 8 and 9. Expressed in the presumptive otic vesicles
CC at stage 9. Expressed in the somites, the entire notochord and the otic
CC epithelium at stage 9. In the developing inner ear, expressed in the
CC entire elongating endolymphatic duct and sac as well as the medial otic
CC epithelium between stages 15 and 23. Expressed in the otic vesicle,
CC somitic mesoderm and notochord at stage 13. Through the cranial region,
CC expressed at the surface ectoderm, head mesenchyme, optic cups, roof
CC plate of the forebrain and notochord at stage 13. In the paraxial
CC mesoderm, expressed in the cranial region of the presomitic mesoderm at
CC stage 13. In the somitic mesoderm, expressed in the somite before de-
CC epithelialization and subsequently in the dermomyotome at stage 13. In
CC the caudal region, expressed in the notochord, paraxial mesoderm and
CC endoderm. Expressed in the optic cup, otic vesicle and somitic mesoderm
CC stage 19. Expressed in the mesenchymal cells surrounding the optic cup
CC and the surface ectoderm overlying the lens vesicle at stage 19.
CC Expressed in the mesonephric ducts and tubules at stage 19. In the
CC somatopleure and limb buds, expressed in the surface ectoderm and
CC mesenchymal cells immediately beneath the surface ectoderm at stage 19.
CC In the somitic mesoderm, expressed in the dermomyotome and lateral
CC sclerotome at stage 19. Expressed in the branchial arches and maxillary
CC process at stages 22 and 23. In the somitic mesoderm, expressed in the
CC myotome at stage 24. In the limb buds, expressed in the anterior region
CC of the fore- and hindlimb buds at stage 24. In the developing inner
CC ear, expressed in the medial side of the utricle, the saccule, and the
CC emerging cochlea at stage 27. {ECO:0000269|PubMed:11731250,
CC ECO:0000269|PubMed:11984879}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM02975.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB69043.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB044337; BAB69043.1; ALT_INIT; mRNA.
DR EMBL; AF421881; AAM02975.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q90YC9; -.
DR SMR; Q90YC9; -.
DR STRING; 9031.ENSGALP00000038858; -.
DR PaxDb; Q90YC9; -.
DR VEuPathDB; HostDB:geneid_373952; -.
DR eggNOG; ENOG502RYP0; Eukaryota.
DR HOGENOM; CLU_115450_0_0_1; -.
DR InParanoid; Q90YC9; -.
DR PhylomeDB; Q90YC9; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IMP:AgBase.
DR GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF018557; DAN_sub; 1.
DR SMART; SM00041; CT; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal; Tumor suppressor.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..177
FT /note="Neuroblastoma suppressor of tumorigenicity 1"
FT /id="PRO_0000364337"
FT DOMAIN 34..123
FT /note="CTCK"
FT REGION 143..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 34..84
FT /evidence="ECO:0000250"
FT DISULFID 48..98
FT /evidence="ECO:0000250"
FT DISULFID 58..117
FT /evidence="ECO:0000250"
FT DISULFID 62..119
FT /evidence="ECO:0000250"
FT DISULFID 81..122
FT /evidence="ECO:0000250"
FT CONFLICT 149..165
FT /note="GPHHYAHHQQEVEEPPA -> SCYPSLCCIKLISLALS (in Ref. 2;
FT AAM02975)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 177 AA; 19495 MW; 42685C5ECA335AB9 CRC64;
MLWFVVGALF PALLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCES KSIQNRACLG
QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLDCPG NDEIPRVDKL VEKILHCSCQ
ACGKEPSHEG ALFNVYLNAE ENMPAEGPGP HHYAHHQQEV EEPPASSHHH HEEEGDE
