ID   NBL1_DANRE              Reviewed;         183 AA.
AC   Q6NZ13;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Neuroblastoma suppressor of tumorigenicity 1;
DE   Flags: Precursor;
GN   Name=nbl1; ORFNames=zgc:77251;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Petko J., Kabbani N., Woll M., Decotiis D., Frey C., Hickey K., Craig M.,
RA   Canfield V., Levenson R.;
RT   "Proteomic analysis of NCS-1 interacting proteins reveals novel signaling
RT   pathways required for inner ear development in Zebrafish.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a tumor suppressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR   EMBL; FJ032030; ACH92116.1; -; mRNA.
DR   EMBL; BC066387; AAH66387.1; -; mRNA.
DR   RefSeq; NP_996980.1; NM_207097.1.
DR   AlphaFoldDB; Q6NZ13; -.
DR   SMR; Q6NZ13; -.
DR   GeneID; 404629; -.
DR   KEGG; dre:404629; -.
DR   CTD; 4681; -.
DR   ZFIN; ZDB-GENE-040426-2357; nbl1.
DR   InParanoid; Q6NZ13; -.
DR   OrthoDB; 1517793at2759; -.
DR   PhylomeDB; Q6NZ13; -.
DR   PRO; PR:Q6NZ13; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0060872; P:semicircular canal development; IMP:ZFIN.
DR   GO; GO:0060876; P:semicircular canal formation; IMP:ZFIN.
DR   GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF018557; DAN_sub; 1.
DR   SMART; SM00041; CT; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal; Tumor suppressor.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..183
FT                   /note="Neuroblastoma suppressor of tumorigenicity 1"
FT                   /id="PRO_0000364338"
FT   DOMAIN          38..127
FT                   /note="CTCK"
FT   REGION          145..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..102
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..121
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..123
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..126
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20037 MW;  809E4B37649163EA CRC64;
     MVMCVRAVLV CVLLELSRAA PHAHINRLAL FPDKSAWCEA KNITQIVGHT GCTPRSIQNR
     ACLGQCFSYS VPNTFPQSTE SLVHCDSCMP AQTQWEVVTL DCSGSDEAPR VDKLVERILH
     CSCQSCSKES SQEGALLQLY PHEGAQDLPS LPDATHTHPQ HAHMQADQRD ADAHLDMHAP
     EAG