NBL1_XENLA
ID NBL1_XENLA Reviewed; 175 AA.
AC O73753;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Neuroblastoma suppressor of tumorigenicity 1;
DE Flags: Precursor;
GN Name=nbl1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BMP2, AND
RP SUBCELLULAR LOCATION.
RX PubMed=9660951; DOI=10.1016/s1097-2765(00)80067-2;
RA Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.;
RT "The Xenopus dorsalizing factor Gremlin identifies a novel family of
RT secreted proteins that antagonize BMP activities.";
RL Mol. Cell 1:673-683(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a tumor suppressor (By similarity). Cytokine that
CC has an axial patterning activity. Acts like bone morpho-genetic protein
CC (BMP) antagonist in embryonic explants. Blocks the bmp2 activity.
CC {ECO:0000250, ECO:0000269|PubMed:9660951}.
CC -!- SUBUNIT: Interacts with bmp2; the interaction is blocked in presence of
CC nog. {ECO:0000269|PubMed:9660951}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9660951}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR EMBL; AF045797; AAC41278.1; -; mRNA.
DR EMBL; BC074404; AAH74404.1; -; mRNA.
DR RefSeq; NP_001079148.1; NM_001085679.1.
DR AlphaFoldDB; O73753; -.
DR SMR; O73753; -.
DR DNASU; 373697; -.
DR GeneID; 373697; -.
DR KEGG; xla:373697; -.
DR CTD; 373697; -.
DR Xenbase; XB-GENE-865248; nbl1.L.
DR OMA; CPGNAEI; -.
DR OrthoDB; 1517793at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 373697; Expressed in internal ear and 19 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0048263; P:determination of dorsal identity; IMP:BHF-UCL.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF018557; DAN_sub; 1.
DR SMART; SM00041; CT; 1.
PE 1: Evidence at protein level;
KW Cytokine; Disulfide bond; Reference proteome; Secreted; Signal;
KW Tumor suppressor.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..175
FT /note="Neuroblastoma suppressor of tumorigenicity 1"
FT /id="PRO_0000364339"
FT DOMAIN 35..124
FT /note="CTCK"
FT REGION 144..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 35..85
FT /evidence="ECO:0000250"
FT DISULFID 49..99
FT /evidence="ECO:0000250"
FT DISULFID 59..118
FT /evidence="ECO:0000250"
FT DISULFID 63..120
FT /evidence="ECO:0000250"
FT DISULFID 82..123
FT /evidence="ECO:0000250"
SQ SEQUENCE 175 AA; 19338 MW; EF44115A1F58C0E3 CRC64;
MTIWFLIGFL LPVAIFAAPP PINRLALFPD KSAWCEAKNI TQIVGHSGCE SKSIQNRACL
GQCFSYSVPN TFPQSTESLV HCDSCMPIDS VWDVVTLECP GNEEFPRVDK LVEKILQCSC
QACGKELSQE GAMFNVYLNT AEDSPAESLG HHQHRPPARE DDSPAQSHRE GESEE
