ID   NBL1_XENTR              Reviewed;         176 AA.
AC   Q6DF53;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Neuroblastoma suppressor of tumorigenicity 1;
DE   Flags: Precursor;
GN   Name=nbl1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a tumor suppressor. Cytokine that has an axial
CC       patterning activity. Acts like bone morpho-genetic protein (BMP)
CC       antagonist in embryonic explants. Blocks the bmp2 activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with bmp2; the interaction is blocked in presence of
CC       nog. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR   EMBL; BC076890; AAH76890.1; -; mRNA.
DR   RefSeq; NP_001006826.1; NM_001006825.1.
DR   AlphaFoldDB; Q6DF53; -.
DR   SMR; Q6DF53; -.
DR   STRING; 8364.ENSXETP00000038222; -.
DR   PaxDb; Q6DF53; -.
DR   DNASU; 448558; -.
DR   GeneID; 448558; -.
DR   KEGG; xtr:448558; -.
DR   CTD; 4681; -.
DR   Xenbase; XB-GENE-479181; nbl1.
DR   eggNOG; ENOG502RYP0; Eukaryota.
DR   HOGENOM; CLU_115450_0_0_1; -.
DR   InParanoid; Q6DF53; -.
DR   OMA; CPGNAEI; -.
DR   OrthoDB; 1517793at2759; -.
DR   PhylomeDB; Q6DF53; -.
DR   TreeFam; TF106445; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF018557; DAN_sub; 1.
DR   SMART; SM00041; CT; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Reference proteome; Secreted; Signal;
KW   Tumor suppressor.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..176
FT                   /note="Neuroblastoma suppressor of tumorigenicity 1"
FT                   /id="PRO_0000364340"
FT   DOMAIN          34..123
FT                   /note="CTCK"
FT   REGION          148..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        34..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..119
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..122
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   176 AA;  19449 MW;  0830220DBCDB5A7F CRC64;
     MTVWLLIGFL LPVAIFAAPP INRLALFPDK SAWCEAKNIT QIVGHSGCES KSIQNRACLG
     QCFSYSVPNT FPQSTESLVH CDSCMPIDSV WDVVTLECPG NEEFPRVDKL VEKILQCSCQ
     ACGKELSQEG AMFNVYLNTA EETLSPAETL GHHHHRPPAR EEDSPAQSQR EGESEE