NBPF7_HUMAN
ID NBPF7_HUMAN Reviewed; 421 AA.
AC P0C2Y1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Putative neuroblastoma breakpoint family member 7;
GN Name=NBPF7P {ECO:0000312|HGNC:HGNC:31989}; Synonyms=NBPF7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC clustered in the p36, p12 and q21 region of the chromosome 1.
CC -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AL359752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001041445.1; NM_001047980.2.
DR AlphaFoldDB; P0C2Y1; -.
DR SMR; P0C2Y1; -.
DR IntAct; P0C2Y1; 1.
DR iPTMnet; P0C2Y1; -.
DR PhosphoSitePlus; P0C2Y1; -.
DR BioMuta; HGNC:31989; -.
DR MassIVE; P0C2Y1; -.
DR PeptideAtlas; P0C2Y1; -.
DR PRIDE; P0C2Y1; -.
DR ProteomicsDB; 52307; -.
DR DNASU; 343505; -.
DR GeneID; 343505; -.
DR CTD; 343505; -.
DR DisGeNET; 343505; -.
DR GeneCards; NBPF7P; -.
DR HGNC; HGNC:31989; NBPF7P.
DR MIM; 613997; gene.
DR neXtProt; NX_P0C2Y1; -.
DR InParanoid; P0C2Y1; -.
DR OrthoDB; 372685at2759; -.
DR PhylomeDB; P0C2Y1; -.
DR PathwayCommons; P0C2Y1; -.
DR BioGRID-ORCS; 343505; 2 hits in 131 CRISPR screens.
DR GenomeRNAi; 343505; -.
DR Pharos; P0C2Y1; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C2Y1; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010630; Olduvai_dom.
DR Pfam; PF06758; Olduvai; 2.
DR SMART; SM01148; DUF1220; 2.
DR PROSITE; PS51316; ODV; 2.
PE 5: Uncertain;
KW Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..421
FT /note="Putative neuroblastoma breakpoint family member 7"
FT /id="PRO_0000288042"
FT DOMAIN 190..279
FT /note="Olduvai 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 280..391
FT /note="Olduvai 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT REGION 179..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..143
FT /evidence="ECO:0000255"
FT COMPBIAS 179..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 170
FT /note="E -> D (in dbSNP:rs6678923)"
FT /id="VAR_032376"
SQ SEQUENCE 421 AA; 48090 MW; 7196B83D41E467C2 CRC64;
MCLRFFSPVP GSTSSATNVT MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNMKQ
KFLVTQMAGF LANQQNKYKY EECKDLIKSM LREELQFKEE KLAEQLKQAE ELRQYKVLVH
SQERELIQLR EKLREGRDAS HSLNQHLQAL LTPDKHDNSQ GQDFREQLAE GCRLARHLVH
KLSPENDTDE DENDKTKELD KVQESPAPRE EQKAEEKEVP EDSLEECAIT YSNSHGPSDS
NPPHKNIKIT SEEDKVNSIL VVDSESSQDE WQDALNILLE NQNDDEEEEG KAPVPPQVTL
WICGLKLQES EEKEVLQDSP EERVTTSCSD HDVSQSYQPC EGTFLALVEQ KVCSAQDVAS
EHSNSKGEET PLGFPDTKYC WKDEKDERMS QKVAFLLDEK NYNSKPSSIP NTTLQGSFTE
D
