NBPF8_HUMAN
ID NBPF8_HUMAN Reviewed; 869 AA.
AC Q3BBV2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Putative neuroblastoma breakpoint family member 8;
GN Name=NBPF8; Synonyms=NBPF8P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Mammary gland;
RX PubMed=16079250; DOI=10.1093/molbev/msi222;
RA Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT "A novel gene family NBPF: intricate structure generated by gene
RT duplications during primate evolution.";
RL Mol. Biol. Evol. 22:2265-2274(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the mammary gland.
CC {ECO:0000269|PubMed:16079250}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC clustered in the p36, p12 and q21 region of the chromosome 1.
CC -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; BX842679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY894573; AAX85112.1; -; mRNA.
DR AlphaFoldDB; Q3BBV2; -.
DR SMR; Q3BBV2; -.
DR IntAct; Q3BBV2; 5.
DR MINT; Q3BBV2; -.
DR iPTMnet; Q3BBV2; -.
DR PhosphoSitePlus; Q3BBV2; -.
DR BioMuta; HGNC:31990; -.
DR DMDM; 121942441; -.
DR EPD; Q3BBV2; -.
DR jPOST; Q3BBV2; -.
DR MassIVE; Q3BBV2; -.
DR MaxQB; Q3BBV2; -.
DR PeptideAtlas; Q3BBV2; -.
DR PRIDE; Q3BBV2; -.
DR ProteomicsDB; 61676; -.
DR GeneCards; NBPF8; -.
DR HGNC; HGNC:31990; NBPF8.
DR MIM; 613998; gene.
DR neXtProt; NX_Q3BBV2; -.
DR PharmGKB; PA142671289; -.
DR InParanoid; Q3BBV2; -.
DR PhylomeDB; Q3BBV2; -.
DR PathwayCommons; Q3BBV2; -.
DR SignaLink; Q3BBV2; -.
DR ChiTaRS; NBPF8; human.
DR Pharos; Q3BBV2; Tdark.
DR PRO; PR:Q3BBV2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q3BBV2; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010630; Olduvai_dom.
DR Pfam; PF06758; Olduvai; 7.
DR SMART; SM01148; DUF1220; 7.
DR PROSITE; PS51316; ODV; 7.
PE 5: Uncertain;
KW Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..869
FT /note="Putative neuroblastoma breakpoint family member 8"
FT /id="PRO_0000288043"
FT DOMAIN 130..224
FT /note="Olduvai 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 401..493
FT /note="Olduvai 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 494..582
FT /note="Olduvai 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 585..640
FT /note="Olduvai 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 641..732
FT /note="Olduvai 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 735..808
FT /note="Olduvai 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 809..869
FT /note="Olduvai 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT REGION 126..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 54..95
FT /evidence="ECO:0000255"
FT COILED 304..366
FT /evidence="ECO:0000255"
FT COMPBIAS 130..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 99215 MW; EE327029B4C572ED CRC64;
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE MFSNSTGRLP GQPTEEIQQY
KVLVHSQERE LTQLKEKLRE GRDASRSLNE HLQALLTLDE PDKSQGQDLQ EQLAEGCRLA
QHLVQKLSPE NDEDEDEDVQ VEEDEKVLES SAPREVQKAE ESKVPEDSLE ECAITCSNSH
GPCDSIQPHK NIKITFEEDK VNSSLVVDRE SSHDGCQDAL NILPVPGPTS SATNVSMVVS
AGPLSSEKAE MNILEINEKL CPQLAEKKQQ FRSLKEKCFV TQVACFLAKQ QNKYKYEECK
DLIKSMLRNE RQFKEEKLAE QLKQAEELRQ YKVLVHSQER ELTQLREKLR EGRDASRSLN
EHLQALLTPD EPDKSQGQDL QEQLAEGCRL AQHLVQKLSP ENDNDDDEDV QVEVAEKVQK
SSSPREMQKA EEKEVPEDSL EECAITCSNS HGPYDSNQPH RKTKITFEED KVDSTLIGSS
SHVEWEDAVH IIPENESDDE EEEEKGPVSP RNLQESEEEE VPQESWDEGY STLSIPPERL
ASYQSYSSTF HSLEEQQVCM AVDIGRHRWD QVKKEDQEAT GPRLSRELLD EKGPEVLQDS
LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS
RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD
QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE
KHVGFSLDVG EIEKKGKGKI GRGRRSKKKR RRGRKEGEED QNPPCPRLNS VLMEVEEPEV
LQDSLDRCYS TPSMYCELRD SFQHYRSVF
