NBPFB_HUMAN
ID NBPFB_HUMAN Reviewed; 865 AA.
AC Q86T75; B1AKG1; B7Z7R4; Q5RGN0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Neuroblastoma breakpoint family member 11 {ECO:0000305};
DE AltName: Full=Neuroblastoma breakpoint family member 24 {ECO:0000312|HGNC:HGNC:31993};
GN Name=NBPF11 {ECO:0000312|HGNC:HGNC:31993};
GN Synonyms=NBPF24 {ECO:0000312|HGNC:HGNC:31993};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=16079250; DOI=10.1093/molbev/msi222;
RA Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT "A novel gene family NBPF: intricate structure generated by gene
RT duplications during primate evolution.";
RL Mol. Biol. Evol. 22:2265-2274(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86T75-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86T75-2; Sequence=VSP_040663, VSP_040664;
CC -!- TISSUE SPECIFICITY: Expressed in spinal cord.
CC {ECO:0000269|PubMed:16079250}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC clustered in the p36, p12 and q21 region of the chromosome 1.
CC -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD89962.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI17086.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI21822.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK302413; BAH13700.1; -; mRNA.
DR EMBL; AL832622; CAD89962.1; ALT_FRAME; mRNA.
DR EMBL; AL356004; CAI17086.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL049742; CAI17086.2; JOINED; Genomic_DNA.
DR EMBL; AL049742; CAI21822.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL356004; CAI21822.2; JOINED; Genomic_DNA.
DR EMBL; BX842679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136292; AAI36293.1; -; mRNA.
DR CCDS; CCDS41381.2; -. [Q86T75-1]
DR RefSeq; NP_001095133.3; NM_001101663.4. [Q86T75-1]
DR RefSeq; NP_899228.4; NM_183372.5. [Q86T75-1]
DR AlphaFoldDB; Q86T75; -.
DR SMR; Q86T75; -.
DR BioGRID; 128294; 3.
DR DIP; DIP-47328N; -.
DR IntAct; Q86T75; 2.
DR MINT; Q86T75; -.
DR STRING; 9606.ENSP00000477509; -.
DR iPTMnet; Q86T75; -.
DR PhosphoSitePlus; Q86T75; -.
DR BioMuta; NBPF11; -.
DR DMDM; 325511389; -.
DR jPOST; Q86T75; -.
DR MassIVE; Q86T75; -.
DR MaxQB; Q86T75; -.
DR PaxDb; Q86T75; -.
DR PeptideAtlas; Q86T75; -.
DR PRIDE; Q86T75; -.
DR Antibodypedia; 74099; 23 antibodies from 9 providers.
DR DNASU; 200030; -.
DR Ensembl; ENST00000614015.4; ENSP00000484213.1; ENSG00000263956.8. [Q86T75-1]
DR Ensembl; ENST00000615281.4; ENSP00000477509.1; ENSG00000263956.8. [Q86T75-1]
DR Ensembl; ENST00000682118.1; ENSP00000507808.1; ENSG00000263956.8. [Q86T75-1]
DR GeneID; 200030; -.
DR KEGG; hsa:200030; -.
DR MANE-Select; ENST00000682118.1; ENSP00000507808.1; NM_001385469.3; NP_001372398.2.
DR UCSC; uc010ozx.3; human. [Q86T75-1]
DR CTD; 200030; -.
DR GeneCards; NBPF11; -.
DR HGNC; HGNC:31993; NBPF11.
DR HPA; ENSG00000263956; Low tissue specificity.
DR MIM; 614001; gene.
DR neXtProt; NX_Q86T75; -.
DR OpenTargets; ENSG00000263956; -.
DR VEuPathDB; HostDB:ENSG00000263956; -.
DR eggNOG; ENOG502RU1I; Eukaryota.
DR GeneTree; ENSGT00420000029746; -.
DR HOGENOM; CLU_004609_0_0_1; -.
DR InParanoid; Q86T75; -.
DR OrthoDB; 372685at2759; -.
DR PhylomeDB; Q86T75; -.
DR TreeFam; TF341151; -.
DR PathwayCommons; Q86T75; -.
DR SignaLink; Q86T75; -.
DR BioGRID-ORCS; 200030; 217 hits in 632 CRISPR screens.
DR ChiTaRS; NBPF11; human.
DR GenomeRNAi; 200030; -.
DR Pharos; Q86T75; Tdark.
DR PRO; PR:Q86T75; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q86T75; protein.
DR Bgee; ENSG00000263956; Expressed in granulocyte and 100 other tissues.
DR ExpressionAtlas; Q86T75; baseline and differential.
DR Genevisible; Q86T75; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010630; Olduvai_dom.
DR Pfam; PF06758; Olduvai; 6.
DR SMART; SM01148; DUF1220; 6.
DR PROSITE; PS51316; ODV; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..865
FT /note="Neuroblastoma breakpoint family member 11"
FT /id="PRO_0000288046"
FT DOMAIN 165..259
FT /note="Olduvai 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 436..528
FT /note="Olduvai 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 529..617
FT /note="Olduvai 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 620..675
FT /note="Olduvai 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 676..767
FT /note="Olduvai 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 770..865
FT /note="Olduvai 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT REGION 161..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..130
FT /evidence="ECO:0000255"
FT COILED 339..401
FT /evidence="ECO:0000255"
FT COMPBIAS 165..179
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 575..598
FT /note="LASYQSYSSTFHSLEEQQVCMAVD -> TSVGSSEKGGPRGNRSQAQQGAAG
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_040663"
FT VAR_SEQ 599..865
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_040664"
SQ SEQUENCE 865 AA; 99433 MW; 7541A8714464D504 CRC64;
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY
EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS
RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE
KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL
VVDRESSHDG CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA
EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA
EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA
EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSSPR EMQKAEEKEV PEDSLEECAI
TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG
RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT DSCQPYRSAF
YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA EKEPEVLQDS LDRCYSTPSG
YLELPDLGQP YRSAVYSLEE QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE
VLQDSLDVIQ LLPVVLNSLT PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ
RRKEEGEEKK GKKIKTHHAP GSAAC
