NBPFE_HUMAN
ID NBPFE_HUMAN Reviewed; 921 AA.
AC Q5TI25; Q5TI23; Q8IX76; Q9UJI9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Neuroblastoma breakpoint family member 14;
GN Name=NBPF14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Rhodes S., Huckle E.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 166-342, AND TISSUE SPECIFICITY.
RX PubMed=16079250; DOI=10.1093/molbev/msi222;
RA Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT "A novel gene family NBPF: intricate structure generated by gene
RT duplications during primate evolution.";
RL Mol. Biol. Evol. 22:2265-2274(2005).
CC -!- INTERACTION:
CC Q5TI25; Q15326: ZMYND11; NbExp=2; IntAct=EBI-2692300, EBI-2623509;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in spleen and fetal liver.
CC {ECO:0000269|PubMed:16079250}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC clustered in the p36, p12 and q21 region of the chromosome 1.
CC -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI20179.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAI20180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20182.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20184.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20185.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI20186.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL117237; CAB55305.1; -; mRNA.
DR EMBL; AL022240; CAI20179.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL022240; CAI20180.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20181.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20182.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20183.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20184.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20185.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL022240; CAI20186.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF379631; AAO15399.1; -; mRNA.
DR AlphaFoldDB; Q5TI25; -.
DR SMR; Q5TI25; -.
DR IntAct; Q5TI25; 3.
DR MINT; Q5TI25; -.
DR iPTMnet; Q5TI25; -.
DR PhosphoSitePlus; Q5TI25; -.
DR BioMuta; NBPF14; -.
DR DMDM; 152123242; -.
DR EPD; Q5TI25; -.
DR jPOST; Q5TI25; -.
DR MassIVE; Q5TI25; -.
DR MaxQB; Q5TI25; -.
DR PaxDb; Q5TI25; -.
DR PeptideAtlas; Q5TI25; -.
DR PRIDE; Q5TI25; -.
DR ProteomicsDB; 65171; -.
DR GeneCards; NBPF14; -.
DR HGNC; HGNC:25232; NBPF14.
DR MIM; 614003; gene.
DR neXtProt; NX_Q5TI25; -.
DR PharmGKB; PA142671273; -.
DR InParanoid; Q5TI25; -.
DR PhylomeDB; Q5TI25; -.
DR PathwayCommons; Q5TI25; -.
DR SignaLink; Q5TI25; -.
DR ChiTaRS; NBPF14; human.
DR Pharos; Q5TI25; Tdark.
DR PRO; PR:Q5TI25; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q5TI25; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010630; Olduvai_dom.
DR Pfam; PF06758; Olduvai; 10.
DR SMART; SM01148; DUF1220; 10.
DR PROSITE; PS51316; ODV; 10.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..921
FT /note="Neuroblastoma breakpoint family member 14"
FT /id="PRO_0000288048"
FT DOMAIN 96..188
FT /note="Olduvai 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 189..260
FT /note="Olduvai 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 261..352
FT /note="Olduvai 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 355..410
FT /note="Olduvai 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 411..503
FT /note="Olduvai 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 504..596
FT /note="Olduvai 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 599..671
FT /note="Olduvai 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 674..729
FT /note="Olduvai 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 730..822
FT /note="Olduvai 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 823..921
FT /note="Olduvai 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT REGION 43..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..61
FT /evidence="ECO:0000255"
FT COMPBIAS 199..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..506
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..825
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 243
FT /note="S -> G (in dbSNP:rs3871941)"
FT /id="VAR_032381"
FT CONFLICT 333
FT /note="N -> D (in Ref. 3; AAO15399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 921 AA; 105853 MW; 3FFFFEBD47514717 CRC64;
MLRNERQFKE EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA
LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSAPR
EMQKAEEKEV PEDSLEECAI TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW
EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYKS
YSSTFHSLEE QQVCMAVDIG RHRWDQVKKE DHEATGPRLS RELLDEKGPE VLQDSLDRCY
STPSGCLELT DSCQPYRSAF YVLEQQRVGL AVNMDEIEKY QEVEEDQDPS CPRLSRELLD
EKEPEVLQDS LGRCYSTPSG YLELPDLGQP YSSAVYSLEE QYLGLALDVD RIKKDQEEEE
DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP DSCQPYGSSF YALEEKHVGF
SLDVGEIEKK GKGKKRRGRR SKKERRRGRK EGEEDQNPPC PRLSRELLDE KGPEVLQDSL
DRCYSTPSGC LELTDSCQPY RSAFYILEQQ RVGLAVDMDE IEKYQEVEED QDPSCPRLSG
ELLDEKEPEV LQESLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQRVGLA VDMDEIEKYQ
EVEEDQDPSC PRLSRELLDE KEPEVLQDSL GRCYSTPSGY LELPDLGQPY SSAVYSLEEQ
YLGLALDVDR IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD
SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP
RLNSMLMEVE EPEVLQDSLD ICYSTPSMYF ELPDSFQHYR SVFYSFEEEH ISFALYVDNR
FFTLTVTSLH LVFQMGVIFP Q
