NBPFF_HUMAN
ID NBPFF_HUMAN Reviewed; 670 AA.
AC Q8N660; A8MPT6; Q3BBV9; Q5SXJ2; Q8IX77;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Neuroblastoma breakpoint family member 15 {ECO:0000312|HGNC:HGNC:28791};
DE AltName: Full=Neuroblastoma breakpoint family member 16 {ECO:0000312|HGNC:HGNC:28791};
GN Name=NBPF15 {ECO:0000312|HGNC:HGNC:28791};
GN Synonyms=NBPF16 {ECO:0000312|HGNC:HGNC:28791};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Mammary gland;
RX PubMed=16079250; DOI=10.1093/molbev/msi222;
RA Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT "A novel gene family NBPF: intricate structure generated by gene
RT duplications during primate evolution.";
RL Mol. Biol. Evol. 22:2265-2274(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-615.
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with a higher expression
CC observed in breast and liver. Also expressed in neuroblastoma cell
CC line. {ECO:0000269|PubMed:16079250}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC clustered in the p36, p12 and q21 region of the chromosome 1.
CC {ECO:0000303|PubMed:16079250}.
CC -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
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DR EMBL; AF379630; AAO15398.1; -; mRNA.
DR EMBL; AY894566; AAX85105.1; -; mRNA.
DR EMBL; AC246785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592492; CAI16654.1; -; Genomic_DNA.
DR EMBL; AL954711; CAM22821.1; -; Genomic_DNA.
DR EMBL; BC023087; AAH23087.1; -; mRNA.
DR CCDS; CCDS72852.1; -.
DR RefSeq; NP_001164226.1; NM_001170755.2.
DR RefSeq; NP_775909.2; NM_173638.4.
DR RefSeq; XP_016856566.1; XM_017001077.1.
DR AlphaFoldDB; Q8N660; -.
DR SMR; Q8N660; -.
DR BioGRID; 129901; 6.
DR IntAct; Q8N660; 7.
DR MINT; Q8N660; -.
DR STRING; 9606.ENSP00000462600; -.
DR iPTMnet; Q8N660; -.
DR PhosphoSitePlus; Q8N660; -.
DR BioMuta; NBPF15; -.
DR DMDM; 74743973; -.
DR EPD; Q8N660; -.
DR jPOST; Q8N660; -.
DR MassIVE; Q8N660; -.
DR MaxQB; Q8N660; -.
DR PaxDb; Q8N660; -.
DR PeptideAtlas; Q8N660; -.
DR PRIDE; Q8N660; -.
DR ProteomicsDB; 63994; -.
DR ProteomicsDB; 72133; -.
DR Antibodypedia; 74526; 12 antibodies from 7 providers.
DR DNASU; 284565; -.
DR Ensembl; ENST00000488031.6; ENSP00000481835.1; ENSG00000266338.7.
DR Ensembl; ENST00000577412.6; ENSP00000462600.1; ENSG00000266338.7.
DR Ensembl; ENST00000581897.7; ENSP00000463178.1; ENSG00000266338.7.
DR GeneID; 284565; -.
DR KEGG; hsa:284565; -.
DR MANE-Select; ENST00000581897.7; ENSP00000463178.1; NM_001385408.1; NP_001372337.1.
DR UCSC; uc010pay.3; human.
DR CTD; 284565; -.
DR DisGeNET; 284565; -.
DR GeneCards; NBPF15; -.
DR HGNC; HGNC:28791; NBPF15.
DR HPA; ENSG00000266338; Low tissue specificity.
DR MIM; 610414; gene.
DR neXtProt; NX_Q8N660; -.
DR OpenTargets; ENSG00000266338; -.
DR PharmGKB; PA142671274; -.
DR VEuPathDB; HostDB:ENSG00000266338; -.
DR eggNOG; ENOG502RU1I; Eukaryota.
DR GeneTree; ENSGT00420000029746; -.
DR HOGENOM; CLU_030855_0_0_1; -.
DR InParanoid; Q8N660; -.
DR OrthoDB; 372685at2759; -.
DR PhylomeDB; Q8N660; -.
DR TreeFam; TF341151; -.
DR PathwayCommons; Q8N660; -.
DR SignaLink; Q8N660; -.
DR BioGRID-ORCS; 284565; 135 hits in 628 CRISPR screens.
DR ChiTaRS; NBPF15; human.
DR GenomeRNAi; 284565; -.
DR Pharos; Q8N660; Tdark.
DR PRO; PR:Q8N660; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N660; protein.
DR Bgee; ENSG00000266338; Expressed in ventricular zone and 100 other tissues.
DR Genevisible; Q8N660; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010630; Olduvai_dom.
DR Pfam; PF06758; Olduvai; 6.
DR SMART; SM01148; DUF1220; 6.
DR PROSITE; PS51316; ODV; 6.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..670
FT /note="Neuroblastoma breakpoint family member 15"
FT /id="PRO_0000288049"
FT DOMAIN 165..257
FT /note="Olduvai 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 258..329
FT /note="Olduvai 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 330..421
FT /note="Olduvai 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 424..479
FT /note="Olduvai 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 480..572
FT /note="Olduvai 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT DOMAIN 573..670
FT /note="Olduvai 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT REGION 180..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..130
FT /evidence="ECO:0000255"
FT COMPBIAS 268..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..576
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 615
FT /note="P -> Q (in dbSNP:rs6695216)"
FT /id="VAR_032383"
FT CONFLICT 477
FT /note="D -> A (in Ref. 3; AAH23087)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="C -> Y (in Ref. 2; CAI16654)"
FT /evidence="ECO:0000305"
FT CONFLICT 592
FT /note="Y -> N (in Ref. 2; CAI16654)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="Q -> L (in Ref. 2; CAI16654)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 77563 MW; 80944E05C2FC4511 CRC64;
MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY
EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH AQERELTQLR EKLREGRDAS
RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE
KVQKSSAPRE MQKAEEKEVP EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL
IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKEPEV
LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC
PRLSRELLDE KEPEVLQDSL DRCYSTPSDY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY
ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LYGVLMEVEE
PEVLQDSLDR CYSTPSMYFE QPDSFQHYRS VFYSFEEEHI SFALYVDNRF FTLTVTSLHL
VFQMGVIFPQ
