NC100_ARATH
ID NC100_ARATH Reviewed; 336 AA.
AC Q9FLJ2; Q8LF13;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=NAC domain-containing protein 100 {ECO:0000303|PubMed:15029955};
DE Short=ANAC100 {ECO:0000303|PubMed:15029955};
DE Short=AtNAC5;
GN Name=NAC100 {ECO:0000312|EMBL:AED97468.1};
GN OrderedLocusNames=At5g61430 {ECO:0000312|Araport:AT5G61430};
GN ORFNames=MFB13.6 {ECO:0000312|EMBL:BAB08499.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [6]
RP INDUCTION BY MIR164.
RX PubMed=15294871; DOI=10.1242/dev.01320;
RA Laufs P., Peaucelle A., Morin H., Traas J.;
RT "MicroRNA regulation of the CUC genes is required for boundary size control
RT in Arabidopsis meristems.";
RL Development 131:4311-4322(2004).
RN [7]
RP INDUCTION BY MIR164.
RX PubMed=17098808; DOI=10.1105/tpc.106.045617;
RA Nikovics K., Blein T., Peaucelle A., Ishida T., Morin H., Aida M.,
RA Laufs P.;
RT "The balance between the MIR164A and CUC2 genes controls leaf margin
RT serration in Arabidopsis.";
RL Plant Cell 18:2929-2945(2006).
RN [8]
RP FUNCTION.
RX PubMed=27021284; DOI=10.1038/srep23609;
RA Oda-Yamamizo C., Mitsuda N., Sakamoto S., Ogawa D., Ohme-Takagi M.,
RA Ohmiya A.;
RT "The NAC transcription factor ANAC046 is a positive regulator of
RT chlorophyll degradation and senescence in Arabidopsis leaves.";
RL Sci. Rep. 6:23609-23609(2016).
CC -!- FUNCTION: Binds to the promoter regions of genes involved in
CC chlorophyll catabolic processes, such as NYC1, SGR1, SGR2 and PAO.
CC {ECO:0000269|PubMed:27021284}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- INDUCTION: Repressed by the microRNA miR164.
CC {ECO:0000269|PubMed:15294871, ECO:0000269|PubMed:17098808}.
CC -!- DOMAIN: The NAC domain includes a DNA-binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM61656.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB010073; BAB08499.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97468.1; -; Genomic_DNA.
DR EMBL; AY054644; AAK96835.1; -; mRNA.
DR EMBL; AY081496; AAM10058.1; -; mRNA.
DR EMBL; AY085102; AAM61656.1; ALT_INIT; mRNA.
DR RefSeq; NP_200951.1; NM_125536.4.
DR AlphaFoldDB; Q9FLJ2; -.
DR SMR; Q9FLJ2; -.
DR IntAct; Q9FLJ2; 1.
DR STRING; 3702.AT5G61430.1; -.
DR PaxDb; Q9FLJ2; -.
DR PRIDE; Q9FLJ2; -.
DR ProteomicsDB; 251316; -.
DR DNASU; 836264; -.
DR EnsemblPlants; AT5G61430.1; AT5G61430.1; AT5G61430.
DR GeneID; 836264; -.
DR Gramene; AT5G61430.1; AT5G61430.1; AT5G61430.
DR KEGG; ath:AT5G61430; -.
DR Araport; AT5G61430; -.
DR TAIR; locus:2163153; AT5G61430.
DR eggNOG; ENOG502QR2M; Eukaryota.
DR HOGENOM; CLU_035664_6_1_1; -.
DR InParanoid; Q9FLJ2; -.
DR OMA; FCGFQKE; -.
DR OrthoDB; 1072945at2759; -.
DR PhylomeDB; Q9FLJ2; -.
DR PRO; PR:Q9FLJ2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLJ2; baseline and differential.
DR Genevisible; Q9FLJ2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..336
FT /note="NAC domain-containing protein 100"
FT /id="PRO_0000407578"
FT DOMAIN 16..166
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 113..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 313..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 38472 MW; 2595C4FBBD8B0680 CRC64;
METFCGFQKE EEQMDLPPGF RFHPTDEELI THYLHKKVLD TSFSAKAIGE VDLNKSEPWE
LPWMAKMGEK EWYFFCVRDR KYPTGLRTNR ATEAGYWKAT GKDKEIYRGK SLVGMKKTLV
FYRGRAPKGQ KTNWVMHEYR LEGKFSAHNL PKTAKNEWVI CRVFQKSAGG KKIPISSLIR
IGSLGTDFNP SLLPSLTDSS PYNDKTKTEP VYVPCFSNQT DQNQGTTLNC FSSPVLNSIQ
ADIFHRIPLY QTQSLQVSMN LQSPVLTQEH SVLHAMIENN RRQSLKTMSV SQETGVSTDM
NTDISSDFEF GKRRFDSQED PSSSTGPVDL EPFWNY
