NC104_ARATH
ID NC104_ARATH Reviewed; 187 AA.
AC Q8GWK6; Q9FLG5;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=NAC domain-containing protein 104 {ECO:0000305};
DE Short=ANAC104 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein XYLEM NAC DOMAIN 1 {ECO:0000312|EMBL:AED97913.1};
GN Name=NAC104 {ECO:0000305}; Synonyms=XND1;
GN OrderedLocusNames=At5g64530 {ECO:0000312|Araport:AT5G64530};
GN ORFNames=MUB3.5 {ECO:0000312|EMBL:BAB11420.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15923329; DOI=10.1104/pp.105.060202;
RA Zhao C., Craig J.C., Petzold H.E., Dickerman A.W., Beers E.P.;
RT "The xylem and phloem transcriptomes from secondary tissues of the
RT Arabidopsis root-hypocotyl.";
RL Plant Physiol. 138:803-818(2005).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18069942; DOI=10.1111/j.1365-313x.2007.03350.x;
RA Zhao C., Avci U., Grant E.H., Haigler C.H., Beers E.P.;
RT "XND1, a member of the NAC domain family in Arabidopsis thaliana,
RT negatively regulates lignocellulose synthesis and programmed cell death in
RT xylem.";
RL Plant J. 53:425-436(2008).
RN [8]
RP FUNCTION.
RX PubMed=20458494; DOI=10.1007/s00425-010-1181-2;
RA Grant E.H., Fujino T., Beers E.P., Brunner A.M.;
RT "Characterization of NAC domain transcription factors implicated in control
RT of vascular cell differentiation in Arabidopsis and Populus.";
RL Planta 232:337-352(2010).
CC -!- FUNCTION: Probable transcription factor that influences tracheary
CC elements and xylem development by negatively regulating secondary cell
CC wall fiber synthesis and programmed cell death.
CC {ECO:0000269|PubMed:18069942, ECO:0000269|PubMed:20458494}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Expressed in root xylem vessels (PubMed:15923329).
CC Expressed in stems, vascular tissue of cauline leaves and tracheary
CC elements of sepals (PubMed:18069942). {ECO:0000269|PubMed:15923329,
CC ECO:0000269|PubMed:18069942}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: Reduced plant height and length of tracheary
CC elements in the stem. {ECO:0000269|PubMed:18069942}.
CC -!- MISCELLANEOUS: Plants over-expressing NAC104 show severe dwarfism and
CC suppression of tracheary element differentiation.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11420.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB010076; BAB11420.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97913.1; -; Genomic_DNA.
DR EMBL; AK118783; BAC43376.1; -; mRNA.
DR EMBL; BT025746; ABF83636.1; -; mRNA.
DR RefSeq; NP_201258.2; NM_125849.4.
DR AlphaFoldDB; Q8GWK6; -.
DR SMR; Q8GWK6; -.
DR STRING; 3702.AT5G64530.1; -.
DR PaxDb; Q8GWK6; -.
DR PRIDE; Q8GWK6; -.
DR EnsemblPlants; AT5G64530.1; AT5G64530.1; AT5G64530.
DR GeneID; 836574; -.
DR Gramene; AT5G64530.1; AT5G64530.1; AT5G64530.
DR KEGG; ath:AT5G64530; -.
DR Araport; AT5G64530; -.
DR TAIR; locus:2174769; AT5G64530.
DR eggNOG; ENOG502QRTS; Eukaryota.
DR HOGENOM; CLU_035664_11_0_1; -.
DR InParanoid; Q8GWK6; -.
DR OMA; PWELNGT; -.
DR OrthoDB; 1236965at2759; -.
DR PhylomeDB; Q8GWK6; -.
DR PRO; PR:Q8GWK6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GWK6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043067; P:regulation of programmed cell death; IMP:TAIR.
DR GO; GO:0048367; P:shoot system development; IMP:TAIR.
DR GO; GO:0048731; P:system development; IBA:GO_Central.
DR GO; GO:0010089; P:xylem development; IMP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..187
FT /note="NAC domain-containing protein 104"
FT /id="PRO_0000435688"
FT DOMAIN 3..155
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 94..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 118..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 21558 MW; 738D4D0C3BD6B392 CRC64;
MNLPPGFRFF PTDEELVVHF LHRKASLLPC HPDVIPDLDL YHYDPWDLPG KALGEGRQWY
FYSRKTQERV TSNGYWGSMG MDEPIYTSST HKKVGIKKYL TFYLGDSQTN WIMQEYSLPD
SSSSSSRSSK RSSRASSSSH KPDYSKWVIC RVYEQNCSEE EDDDGTELSC LDEVFLSLDD
LDEVSLP
