NC105_ARATH
ID NC105_ARATH Reviewed; 292 AA.
AC Q9FH59;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=NAC domain-containing protein 105 {ECO:0000303|PubMed:15029955};
DE Short=ANAC105 {ECO:0000303|PubMed:15029955};
DE AltName: Full=Protein VASCULAR RELATED NAC-DOMAIN 3 {ECO:0000303|PubMed:16103214};
GN Name=NAC105 {ECO:0000303|PubMed:15029955};
GN Synonyms=VND3 {ECO:0000303|PubMed:16103214};
GN OrderedLocusNames=At5g66300 {ECO:0000312|Araport:AT5G66300};
GN ORFNames=K1L20.8 {ECO:0000312|EMBL:BAB10709.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [5]
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16103214; DOI=10.1101/gad.1331305;
RA Kubo M., Udagawa M., Nishikubo N., Horiguchi G., Yamaguchi M., Ito J.,
RA Mimura T., Fukuda H., Demura T.;
RT "Transcription switches for protoxylem and metaxylem vessel formation.";
RL Genes Dev. 19:1855-1860(2005).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=17565617; DOI=10.1111/j.1365-313x.2007.03109.x;
RA Ko J.-H., Yang S.H., Park A.H., Lerouxel O., Han K.-H.;
RT "ANAC012, a member of the plant-specific NAC transcription factor family,
RT negatively regulates xylary fiber development in Arabidopsis thaliana.";
RL Plant J. 50:1035-1048(2007).
RN [7]
RP TISSUE SPECIFICITY, AND INTERACTION WITH NAC030/VND7.
RC STRAIN=cv. Columbia;
RX PubMed=18445131; DOI=10.1111/j.1365-313x.2008.03533.x;
RA Yamaguchi M., Kubo M., Fukuda H., Demura T.;
RT "Vascular-related NAC-DOMAIN7 is involved in the differentiation of all
RT types of xylem vessels in Arabidopsis roots and shoots.";
RL Plant J. 55:652-664(2008).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=25148240; DOI=10.1371/journal.pone.0105726;
RA Zhou J., Zhong R., Ye Z.-H.;
RT "Arabidopsis NAC domain proteins, VND1 to VND5, are transcriptional
RT regulators of secondary wall biosynthesis in vessels.";
RL PLoS ONE 9:E105726-E105726(2014).
CC -!- FUNCTION: Transcription activator that binds to the secondary wall NAC
CC binding element (SNBE), 5'-
CC (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of
CC target genes (By similarity). Involved in xylem formation by promoting
CC the expression of secondary wall-associated transcription factors and
CC of genes involved in secondary wall biosynthesis and programmed cell
CC death, genes driven by the secondary wall NAC binding element (SNBE).
CC Triggers thickening of secondary walls (PubMed:25148240).
CC {ECO:0000250|UniProtKB:Q9LVA1, ECO:0000269|PubMed:25148240}.
CC -!- SUBUNIT: Interacts with NAC030/VND7. {ECO:0000269|PubMed:18445131}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C8W9,
CC ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- TISSUE SPECIFICITY: Detected in root protoxylem and metaxylem poles and
CC in vessels of protoxylems, outermost metaxylems, inner metaxylems,
CC shoots and hypocotyls. Expressed in roots, hypocotyls, cotyledons and
CC leaves (PubMed:18445131). Present in developing xylems
CC (PubMed:16103214, PubMed:17565617). Present in root developing xylems
CC (PubMed:16103214). Specifically expressed in vessels but not in
CC interfascicular fibers in stems (PubMed:25148240).
CC {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:17565617,
CC ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:25148240}.
CC -!- DEVELOPMENTAL STAGE: Up-regulated during xylem vessel element
CC formation. Expressed preferentially in procambial cells adjacent to
CC root meristem. {ECO:0000269|PubMed:16103214,
CC ECO:0000269|PubMed:25148240}.
CC -!- DOMAIN: The NAC domain includes a DNA binding domain and a dimerization
CC domain. {ECO:0000255|PROSITE-ProRule:PRU00353}.
CC -!- DISRUPTION PHENOTYPE: Reduced secondary wall thickening in vessels and
CC collapsed vessel. {ECO:0000269|PubMed:25148240}.
CC -!- SIMILARITY: Belongs to the plant vascular related NAC-domain protein
CC family. {ECO:0000305}.
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DR EMBL; AB022211; BAB10709.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98196.1; -; Genomic_DNA.
DR EMBL; BT015824; AAU94387.1; -; mRNA.
DR EMBL; BT020216; AAV59282.1; -; mRNA.
DR RefSeq; NP_201431.1; NM_126028.3.
DR AlphaFoldDB; Q9FH59; -.
DR SMR; Q9FH59; -.
DR IntAct; Q9FH59; 8.
DR STRING; 3702.AT5G66300.1; -.
DR PaxDb; Q9FH59; -.
DR PRIDE; Q9FH59; -.
DR DNASU; 836762; -.
DR EnsemblPlants; AT5G66300.1; AT5G66300.1; AT5G66300.
DR GeneID; 836762; -.
DR Gramene; AT5G66300.1; AT5G66300.1; AT5G66300.
DR KEGG; ath:AT5G66300; -.
DR Araport; AT5G66300; -.
DR TAIR; locus:2155046; AT5G66300.
DR eggNOG; ENOG502QQGU; Eukaryota.
DR HOGENOM; CLU_035664_1_2_1; -.
DR InParanoid; Q9FH59; -.
DR OMA; WDSNCFL; -.
DR OrthoDB; 825417at2759; -.
DR PhylomeDB; Q9FH59; -.
DR PRO; PR:Q9FH59; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FH59; baseline and differential.
DR Genevisible; Q9FH59; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:1901348; P:positive regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0048759; P:xylem vessel member cell differentiation; IMP:TAIR.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 1: Evidence at protein level;
KW Activator; Cell wall biogenesis/degradation; Developmental protein;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..292
FT /note="NAC domain-containing protein 105"
FT /id="PRO_0000433124"
FT DOMAIN 12..162
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 112..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT REGION 237..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 34321 MW; 080F2049212AA905 CRC64;
MMKVDQDYSC SIPPGFRFHP TDEELVGYYL KKKIASQRID LDVIREIDLY KIEPWDLQER
CRIGYEEQTE WYFFSHRDKK YPTGTRTNRA TVAGFWKATG RDKAVYLNSK LIGMRKTLVF
YRGRAPNGQK SDWIIHEYYS LESHQNSPPQ EEGWVVCRAF KKRTTIPTKR RQLWDPNCLF
YDDATLLEPL DKRARHNPDF TATPFKQELL SEASHVQDGD FGSMYLQCID DDQFSQLPQL
ESPSLPSEIT PHSTTFSENS SRKDDMSSEK RITDWRYLDK FVASQFLMSG ED
