ID   NC2B_DICDI              Reviewed;         178 AA.
AC   Q55DJ5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Protein Dr1 homolog;
DE   AltName: Full=Negative cofactor 2-beta homolog;
DE            Short=NC2-beta homolog;
GN   Name=dr1; ORFNames=DDB_G0269638;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in transcriptional regulation. Component of the NC2
CC       complex which represses RNA polymerase II transcription through binding
CC       to tbp and thereby inhibiting the assembly of the preinitiation complex
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with drap1 to form the negative cofactor 2 (NC2)
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NC2 beta/DR1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72169.1; -; Genomic_DNA.
DR   RefSeq; XP_646136.1; XM_641044.1.
DR   AlphaFoldDB; Q55DJ5; -.
DR   SMR; Q55DJ5; -.
DR   STRING; 44689.DDB0216393; -.
DR   PaxDb; Q55DJ5; -.
DR   EnsemblProtists; EAL72169; EAL72169; DDB_G0269638.
DR   GeneID; 8617086; -.
DR   KEGG; ddi:DDB_G0269638; -.
DR   dictyBase; DDB_G0269638; dr1.
DR   eggNOG; KOG0871; Eukaryota.
DR   HOGENOM; CLU_066247_11_1_1; -.
DR   InParanoid; Q55DJ5; -.
DR   OMA; ANDICGR; -.
DR   PhylomeDB; Q55DJ5; -.
DR   PRO; PR:Q55DJ5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0017054; C:negative cofactor 2 complex; IBA:GO_Central.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0017025; F:TBP-class protein binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR042225; Ncb2.
DR   PANTHER; PTHR46138; PTHR46138; 1.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..178
FT                   /note="Protein Dr1 homolog"
FT                   /id="PRO_0000327818"
FT   REGION          139..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   178 AA;  20052 MW;  8524D041DC8611F6 CRC64;
     MGDKNDKEDN LSLPKATVSK LIKEMLPQDV KCSNETRDLI LECCVEFIHL ISSEANDICG
     REQKRTIAAE HVIKALTELG FSDYTQKVSD VYDKHKLEVS TKSKSSKKFE NLGKPTEQLI
     REQQLLFAKA RSAFQASPEA QQLQQLQQQQ QQQQGGLQAP SVQQQTDINT TTTSTIQK