ID   NCA2_ASHGO              Reviewed;         569 AA.
AC   Q753J1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Nuclear control of ATPase protein 2;
GN   Name=NCA2; OrderedLocusNames=AFR321C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in the mitochondrial expression of subunits 6 and 8
CC       of the F0-F1 ATP synthase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AE016819; AAS53692.1; -; Genomic_DNA.
DR   RefSeq; NP_985868.1; NM_211223.1.
DR   AlphaFoldDB; Q753J1; -.
DR   STRING; 33169.AAS53692; -.
DR   EnsemblFungi; AAS53692; AAS53692; AGOS_AFR321C.
DR   GeneID; 4622132; -.
DR   KEGG; ago:AGOS_AFR321C; -.
DR   eggNOG; ENOG502QTT6; Eukaryota.
DR   HOGENOM; CLU_008227_2_0_1; -.
DR   InParanoid; Q753J1; -.
DR   OMA; NRIYHVY; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0009060; P:aerobic respiration; IEA:EnsemblFungi.
DR   GO; GO:0016071; P:mRNA metabolic process; IEA:EnsemblFungi.
DR   InterPro; IPR013946; NCA2.
DR   PANTHER; PTHR28234; PTHR28234; 2.
DR   Pfam; PF08637; NCA2; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..569
FT                   /note="Nuclear control of ATPase protein 2"
FT                   /id="PRO_0000096753"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   569 AA;  64533 MW;  DF12C19072455BA0 CRC64;
     MIASRYVASE LESVTRKLEL QLYERAAISE VLEQTSTDLE LAKANEVLQT IKEEADACVA
     AINGGQKFYT IKYDQILSGL ESLSGGQWSV GSPLEPLIRD GISDYLHILL YYALLSKNLA
     KLPQLLLDQE YYGHVSRCSW FMRLFYGLQI MPVKLIEFFR GHALQELPSK LRQTLRIHNF
     QLVGLPTQRA WQWTKLPIAM VDTDIIQKTA SLDSQLDINV KKFGKLLREF PRQKSDRLEV
     LSDFLDLKPG SSEFAVVRAV QKWNVDSCAP QPNWIVRYWP TILIALAGGP AGIAAIWNAR
     NDIAAFIKHN LFEFARDLVK NWLVEPLRNI WSTVHHDPTS SIAIMSQGTL DTEINSLQRM
     LIDFLKEHEY ANTVDTSVLM KEIEQGNLTQ FMEIYEAQLR KPIRNLVTGD LIRSLLIQIQ
     KGKVDGSLAI HGIDKLLQSQ QLVFGIVSIS PALLILYVLC NSLTKLVKYG TVWSKGAKYR
     RSVSVSLNNV ERLLNSPIEE FDGDKGNWNL GLLTLEMANL REYGAKLVPH SRTAEWCRDI
     DEMASSSALS TTGKLNVINR IYHVYGKYF